DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and FBXL7

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_036436.1	Gene:	FBXL7 / 23194	HGNCID:	13604	Length:	491	Species:	Homo sapiens

Alignment Length:	521	Identity:	218/521 - (41%)
Similarity:	317/521 - (60%)	Gaps:	72/521 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 SETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCNLGRFSPSLDQGYATLVSPSP------------ 334
            ||..||.....:.||:::|..:|.|.      |:.. |...|....||.:|||
Human    11 SEGKGSSSISSDVSSSTDHTPTKAQK------NVAT-SEDSDLSMRTLSTPSPALICPPNLPGFQ 68

  Fly   335 TGHHSSGGAGNVTNSTTASGAGIMASSTPTT-----------TPRRGASSNGLGGGAASAIGPPP 388
            .|..||..:.::|..|.|     |..|.|.|           .|::..:|
Human    69 NGRGSSTSSSSITGETVA-----MVHSPPPTRLTHPLIRLASRPQKEQAS--------------- 113

  Fly   389 WNRKGPFRCGPLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVISLRGEHLNG 453
                        .|||||.::|:|||:|.:.:||..||||||:.:|||.|.||:.|.|.||.:|.
Human   114 ------------IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINV 166

  Fly   454 DKTLKMIFRQLCGQSCNGACPEVERVMLADGC-RISDKGLQLLTRRCPELTHLQLQTCVDITNQA 517
            |:.||::.|:|| |.....|..:|.|.:: || |::|:||..:.:.||||..|::..|.:|:|:|
Human   167 DRALKVLTRRLC-QDTPNVCLMLETVTVS-GCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEA 229

  Fly   518 LVEALTKCSNLQHLDVTGCSQVSSIS----PNPHMEP--PRRLLLQYLDLTDCMAIDDMGLKIVV 576
            :.:.::.|.||:||||:|||:|:.||    .:..:.|  .:::.::|||:|||..::|.||..:.
Human   230 VFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIA 294

  Fly   577 KNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAK 641
            .:|.||.:||||||:::||.||:::..:|.|:||||||||..::||||.|:|||.:.|||||:|.
Human   295 AHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAH 359

  Fly   642 CERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLARSCPRLRALDIGKCD-VSDAGLRALA 705
            |.||:|.|::.:|:.|.|||||||||||.::|..:..||::|.:|::||||||. |||.||..||
Human   360 CGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLA 424

  Fly   706 ESCPNLKKLSLRSCDMITDRGVQCIAYYCRGLQQLNIQDCPVSIEGYRAVKKYCKRCIIEHTNPG 770
            .:|.|||:|||:||:.||.:|:|.:|..|..||.||:|||.||:|..|.||::||||:||||||.
Human   425 LNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPA 489

  Fly   771 F 771
            |
Human   490 F 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	25/45 (56%)
		leucine-rich repeat	441..460	CDD:275381	9/18 (50%)
		AMN1	<451..595	CDD:187754	58/150 (39%)
		leucine-rich repeat	476..501	CDD:275381	9/25 (36%)
		leucine-rich repeat	502..521	CDD:275381	6/18 (33%)
		leucine-rich repeat	528..555	CDD:275381	12/32 (38%)
		leucine-rich repeat	556..581	CDD:275381	10/24 (42%)
		AMN1	577..746	CDD:187754	94/169 (56%)
		leucine-rich repeat	582..607	CDD:275381	12/24 (50%)
		leucine-rich repeat	608..633	CDD:275381	16/24 (67%)
		leucine-rich repeat	634..659	CDD:275381	13/24 (54%)
		leucine-rich repeat	660..685	CDD:275381	14/24 (58%)
		leucine-rich repeat	686..710	CDD:275381	15/24 (63%)
		leucine-rich repeat	711..735	CDD:275381	12/23 (52%)
		leucine-rich repeat	737..761	CDD:275381	14/23 (61%)
FBXL7	NP_036436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79		20/74 (27%)
		F-box-like	114..157	CDD:372399	24/42 (57%)
		leucine-rich repeat	129..151	CDD:275381	12/21 (57%)
		leucine-rich repeat	154..187	CDD:275381	14/33 (42%)
		LRR 1	170..195		9/26 (35%)
		AMN1	<185..366	CDD:187754	81/181 (45%)
		leucine-rich repeat	188..213	CDD:275381	9/25 (36%)
		LRR 2	196..221		10/24 (42%)
		leucine-rich repeat	214..234	CDD:275381	6/19 (32%)
		LRR 3	222..247		11/24 (46%)
		leucine-rich repeat	240..273	CDD:275381	12/32 (38%)
		LRR 4	253..281		6/27 (22%)
		leucine-rich repeat	274..299	CDD:275381	10/24 (42%)
		LRR 5	282..307		10/24 (42%)
		AMN1	297..464	CDD:187754	93/166 (56%)
		leucine-rich repeat	300..325	CDD:275381	12/24 (50%)
		LRR 6	308..333		12/24 (50%)
		leucine-rich repeat	326..351	CDD:275381	16/24 (67%)
		LRR 7	334..359		14/24 (58%)
		leucine-rich repeat	352..377	CDD:275381	13/24 (54%)
		LRR 8	360..385		14/24 (58%)
		leucine-rich repeat	378..403	CDD:275381	14/24 (58%)
		LRR 9	386..411		10/24 (42%)
		leucine-rich repeat	404..429	CDD:275381	15/24 (63%)
		LRR 10	412..437		15/24 (63%)
		leucine-rich repeat	430..453	CDD:275381	12/22 (55%)
		LRR 11	438..463		11/24 (46%)
		leucine-rich repeat	456..480	CDD:275381	14/23 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7219
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H69121
Inparanoid	1	1.050	398	1.000	Inparanoid score	I1959
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	1	1.000	-	-		FOG0006053
OrthoInspector	1	1.000	-	-		oto90936
orthoMCL	1	0.900	-	-		OOG6_107386
Panther	1	1.100	-	-	LDO	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	1	1.000	-	-		X4348
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	12	11.900