Protein Alignment Fbxl7 and FBXL7

DIOPT Version :10

• Sequence 1: NP_650512.1
• Gene: Fbxl7 / 41935
• FlyBaseID: FBgn0038385
• Length: 772
• Species: Drosophila melanogaster
• Sequence 2: NP_036436.1
• Gene: FBXL7 / 23194
• HGNCID: 13604
• Length: 491
• Species: Homo sapiens
• Alignment Length: 521
• Identity: 218/521 - (41%)
• Similarity: 317/521 - (60%)
• Gaps: 72/521 - (13%)

  Fly   282 SETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCNLGRFSPSLDQGYATLVSPSP------------ 334
            ||..||.....:.||:::|..:|.|.      |:.. |...|....||.:|||
Human    11 SEGKGSSSISSDVSSSTDHTPTKAQK------NVAT-SEDSDLSMRTLSTPSPALICPPNLPGFQ 68

  Fly   335 TGHHSSGGAGNVTNSTTASGAGIMASSTPTT-----------TPRRGASSNGLGGGAASAIGPPP 388
            .|..||..:.::|..|.|     |..|.|.|           .|::..:|
Human    69 NGRGSSTSSSSITGETVA-----MVHSPPPTRLTHPLIRLASRPQKEQAS--------------- 113

  Fly   389 WNRKGPFRCGPLFDRLPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVISLRGEHLNG 453
                        .|||||.::|:|||:|.:.:||..||||||:.:|||.|.||:.|.|.||.:|.
Human   114 ------------IDRLPDHSMVQIFSFLPTNQLCRCARVCRRWYNLAWDPRLWRTIRLTGETINV 166

  Fly   454 DKTLKMIFRQLCGQSCNGACPEVERVMLADGC-RISDKGLQLLTRRCPELTHLQLQTCVDITNQA 517
            |:.||::.|:|| |.....|..:|.|.:: || |::|:||..:.:.||||..|::..|.:|:|:|
Human   167 DRALKVLTRRLC-QDTPNVCLMLETVTVS-GCRRLTDRGLYTIAQCCPELRRLEVSGCYNISNEA 229

  Fly   518 LVEALTKCSNLQHLDVTGCSQVSSIS----PNPHMEP--PRRLLLQYLDLTDCMAIDDMGLKIVV 576
            :.:.::.|.||:||||:|||:|:.||    .:..:.|  .:::.::|||:|||..::|.||..:.
Human   230 VFDVVSLCPNLEHLDVSGCSKVTCISLTREASIKLSPLHGKQISIRYLDMTDCFVLEDEGLHTIA 294

  Fly   577 KNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAK 641
            .:|.||.:||||||:::||.||:::..:|.|:||||||||..::||||.|:|||.:.|||||:|.
Human   295 AHCTQLTHLYLRRCVRLTDEGLRYLVIYCASIKELSVSDCRFVSDFGLREIAKLESRLRYLSIAH 359

  Fly   642 CERVSDAGLKVIARRCYKLRYLNARGCEAVSDDSITVLARSCPRLRALDIGKCD-VSDAGLRALA 705
            |.||:|.|::.:|:.|.|||||||||||.::|..:..||::|.:|::||||||. |||.||..||
Human   360 CGRVTDVGIRYVAKYCSKLRYLNARGCEGITDHGVEYLAKNCTKLKSLDIGKCPLVSDTGLECLA 424

  Fly   706 ESCPNLKKLSLRSCDMITDRGVQCIAYYCRGLQQLNIQDCPVSIEGYRAVKKYCKRCIIEHTNPG 770
            .:|.|||:|||:||:.||.:|:|.:|..|..||.||:|||.||:|..|.||::||||:||||||.
Human   425 LNCFNLKRLSLKSCESITGQGLQIVAANCFDLQTLNVQDCEVSVEALRFVKRHCKRCVIEHTNPA 489

  Fly   771 F 771
            |
Human   490 F 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	leucine-rich repeat	502..521	CDD:275381	6/18 (33%)
		leucine-rich repeat	528..555	CDD:275381	12/32 (38%)
		leucine-rich repeat	556..581	CDD:275381	10/24 (42%)
		AMN1	577..746	CDD:187754	94/169 (56%)
		leucine-rich repeat	582..607	CDD:275381	12/24 (50%)
		leucine-rich repeat	608..633	CDD:275381	16/24 (67%)
		leucine-rich repeat	634..659	CDD:275381	13/24 (54%)
		leucine-rich repeat	660..685	CDD:275381	14/24 (58%)
		leucine-rich repeat	686..710	CDD:275381	15/24 (63%)
		leucine-rich repeat	711..735	CDD:275381	12/23 (52%)
		leucine-rich repeat	737..761	CDD:275381	14/23 (61%)
		dermokine	<279..>394	CDD:455732	29/134 (22%)
		F-box_SF	401..444	CDD:459239	24/42 (57%)
		leucine-rich repeat	441..460	CDD:275381	9/18 (50%)
		leucine-rich repeat	476..501	CDD:275381	9/25 (36%)
		LRR	<483..>640	CDD:443914	74/163 (45%)
FBXL7	NP_036436.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..79		20/74 (27%)
		F-box_FBXL7	114..157	CDD:438892	24/42 (57%)
		leucine-rich repeat	129..151	CDD:275381	12/21 (57%)
		leucine-rich repeat	154..187	CDD:275381	14/33 (42%)
		LRR 1	170..195		9/26 (35%)
		AMN1	<185..366	CDD:187754	81/181 (45%)
		leucine-rich repeat	188..213	CDD:275381	9/25 (36%)
		LRR 2	196..221		10/24 (42%)
		leucine-rich repeat	214..234	CDD:275381	6/19 (32%)
		LRR 3	222..247		11/24 (46%)
		leucine-rich repeat	240..273	CDD:275381	12/32 (38%)
		LRR 4	253..281		6/27 (22%)
		leucine-rich repeat	274..299	CDD:275381	10/24 (42%)
		LRR 5	282..307		10/24 (42%)
		AMN1	297..464	CDD:187754	93/166 (56%)
		leucine-rich repeat	300..325	CDD:275381	12/24 (50%)
		LRR 6	308..333		12/24 (50%)
		leucine-rich repeat	326..351	CDD:275381	16/24 (67%)
		LRR 7	334..359		14/24 (58%)
		leucine-rich repeat	352..377	CDD:275381	13/24 (54%)
		LRR 8	360..385		14/24 (58%)
		leucine-rich repeat	378..403	CDD:275381	14/24 (58%)
		LRR 9	386..411		10/24 (42%)
		leucine-rich repeat	404..429	CDD:275381	15/24 (63%)
		LRR 10	412..437		15/24 (63%)
		leucine-rich repeat	430..453	CDD:275381	12/22 (55%)
		LRR 11	438..463		11/24 (46%)
		leucine-rich repeat	456..480	CDD:275381	14/23 (61%)