DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and FBXL13

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001381423.1	Gene:	FBXL13 / 222235	HGNCID:	21658	Length:	825	Species:	Homo sapiens

Alignment Length:	506	Identity:	112/506 - (22%)
Similarity:	195/506 - (38%)	Gaps:	171/506 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   404 LPDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPI-----LWKVI----------------SLR 447
            ||:.|:::||.:|...::.    :|.:..| ||..:     ||..|                :|:
Human   248 LPERAILQIFFYLSLKDVI----ICGQVNH-AWMLMTQLNSLWNAIDFSSVKNVIPDKYIVSTLQ 307

  Fly   448 GEHLNGDKTLKMIFR-------------------QLCGQSC-----------NGACPEV------ 476
            ...||   .|::.||                   :|....|           :..||.|
Human   308 RWRLN---VLRLNFRGCLLRPKTFRSVSHCRNLQELNVSDCPTFTDESMRHISEGCPGVLCLNLS 369

  Fly   477 -------------------ERVMLADGCRISDKGLQLLT--RRCPELTHLQLQTCVDITNQALVE 520
                               :.:.||...|.:|||||.|.  ..|.:|.:|.|..|..|:.|....
Human   370 NTTITNRTMRLLPRHFHNLQNLSLAYCRRFTDKGLQYLNLGNGCHKLIYLDLSGCTQISVQGFRY 434

  Fly   521 ALTKCSNLQHLDVTG---------------CSQVSSI--SPNPHMEPPRRLLLQYLDLTDC---- 564
            ....|:.:.||.:..               ||:::|:  :..||             ::||
Human   435 IANSCTGIMHLTINDMPTLTDNCVKALVEKCSRITSLVFTGAPH-------------ISDCTFRA 486

  Fly   565 --------------MAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSV-- 613
                          ..:.|...|.:.||.|.|.::|:..|..:||:.|:.:.    .||:|:|
Human   487 LSACKLRKIRFEGNKRVTDASFKFIDKNYPNLSHIYMADCKGITDSSLRSLS----PLKQLTVLN 547

  Fly   614 -SDCLNITDFGLYELAKLGAALRY--LSVAKCERVSDAGLKVIARRCYKLRYLNARGCE------ 669
             ::|:.|.|.||.:.....|::|.  |:::.|.|:|||.:..::.||..|.||:.|.||
Human   548 LANCVRIGDMGLKQFLDGPASMRIRELNLSNCVRLSDASVMKLSERCPNLNYLSLRNCEHLTAQG 612

  Fly   670 ------------------AVSDDSITVLARSCPRLRALDIGKC-DVSDAGLRALAESCPNLKKLS 715
                              .:|::.:.||:|. .:|:.|.:.:| .::|.|::|..:|...|:.|.
Human   613 IGYIVNIFSLVSIDLSGTDISNEGLNVLSRH-KKLKELSVSECYRITDDGIQAFCKSSLILEHLD 676

  Fly   716 LRSCDMITDRGVQCIAYYCRGLQQLNIQDCPVSIEGYRAVKKYCKRCIIEH 766
            :..|..::|..::.:|.||..|..|:|..||...:.  |::....:|...|
Human   677 VSYCSQLSDMIIKALAIYCINLTSLSIAGCPKITDS--AMEMLSAKCHYLH 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	13/63 (21%)
		leucine-rich repeat	441..460	CDD:275381	6/34 (18%)
		AMN1	<451..595	CDD:187754	44/235 (19%)
		leucine-rich repeat	476..501	CDD:275381	11/51 (22%)
		leucine-rich repeat	502..521	CDD:275381	6/18 (33%)
		leucine-rich repeat	528..555	CDD:275381	7/43 (16%)
		leucine-rich repeat	556..581	CDD:275381	6/42 (14%)
		AMN1	577..746	CDD:187754	55/198 (28%)
		leucine-rich repeat	582..607	CDD:275381	6/24 (25%)
		leucine-rich repeat	608..633	CDD:275381	9/27 (33%)
		leucine-rich repeat	634..659	CDD:275381	9/26 (35%)
		leucine-rich repeat	660..685	CDD:275381	10/48 (21%)
		leucine-rich repeat	686..710	CDD:275381	7/24 (29%)
		leucine-rich repeat	711..735	CDD:275381	6/23 (26%)
		leucine-rich repeat	737..761	CDD:275381	6/23 (26%)
FBXL13	NP_001381423.1	Sfi1	<112..>224	CDD:400658
		F-box-like	245..289	CDD:403981	12/45 (27%)
		leucine-rich repeat	285..312	CDD:275381	3/26 (12%)
		AMN1	312..497	CDD:187754	35/200 (18%)
		leucine-rich repeat	313..336	CDD:275381	3/22 (14%)
		leucine-rich repeat	337..362	CDD:275381	3/24 (13%)
		leucine-rich repeat	363..387	CDD:275381	1/23 (4%)
		leucine-rich repeat	388..406	CDD:275381	7/17 (41%)
		leucine-rich repeat	416..441	CDD:275381	7/24 (29%)
		leucine-rich repeat	442..491	CDD:275381	9/61 (15%)
		leucine-rich repeat	468..490	CDD:275381	5/34 (15%)
		leucine-rich repeat	492..515	CDD:275381	3/22 (14%)
		leucine-rich repeat	518..542	CDD:275381	7/27 (26%)
		AMN1	529..737	CDD:187754	54/204 (26%)
		leucine-rich repeat	543..570	CDD:275381	8/26 (31%)
		leucine-rich repeat	571..596	CDD:275381	8/24 (33%)
		leucine-rich repeat	597..645	CDD:275381	10/48 (21%)
		leucine-rich repeat	646..671	CDD:275381	7/24 (29%)
		leucine-rich repeat	672..697	CDD:275381	7/24 (29%)
		leucine-rich repeat	698..723	CDD:275381	7/26 (27%)
		leucine-rich repeat	724..749	CDD:275381	1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840