DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Fbxl7 and Fbxl21

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001333661.1	Gene:	Fbxl21 / 213311	MGIID:	2442921	Length:	460	Species:	Mus musculus

Alignment Length:	437	Identity:	91/437 - (20%)
Similarity:	162/437 - (37%)	Gaps:	97/437 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   357 IMASSTPTTTPRRGASSNGLGGGAASAIGPPPWNRKGPFRCGPLFDRLPDEAVVRIFSWLDSCEL 421
            ::.||.....|:||..|:.....|.|.:  ..|.            .||...:::||.:|...:.
Mouse    38 VVQSSPVVKQPKRGLCSSLRQTHALSVL--LDWG------------TLPHHVILQIFQYLPLIDR 88

  Fly   422 CNVARVCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGCR 486
            ...:.||||:..:...|.||:....   .||...|  ..|:        ...|::.:
Mouse    89 ARASSVCRRWNEVFHIPDLWRKFEF---ELNQSAT--SYFK--------STHPDLIQ-------- 132

  Fly   487 ISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPHMEPP 551
                  |::.:....|.::..:  ||.:.::...|....|.|.:..:.....:|:..|: .|..|
Mouse   133 ------QIIKKHAAHLQYVSFK--VDSSTESAEAACDILSQLVNCSIQTLGLISTAKPS-FMNVP 188

  Fly   552 RRLLLQYLDLT------------DCMAIDDMGLKIVV-KNCPQLVYLYLRRCIQVTDAGLKFVPS 603
            :...:..|.:.            :...:||..|||:| .|...|..|.:..|..|:..|:..|..
Mouse   189 KSHFVSALTVVFVNSKSLSSIKIEDTPVDDPSLKILVANNSDTLRLLKMSSCPHVSSDGILCVAD 253

  Fly   604 FCVSLKELS-----VSD----------CLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVI 653
            .|..|:||:     :||          .:|:....:..:::....:::.|:.|  |..||.:|..
Mouse   254 HCQGLRELALNYYILSDEILLALSSETHVNLEHLRIDVVSENPGQIKFHSIKK--RSWDALIKHS 316

  Fly   654 AR-RCYKLRYLNARGCEAVSDD-------------SITVLAR---SCPRLRALDIGKCDVS---- 697
            .| ......:|.....||...:             |..:|.|   :||||  :::..|...
Mouse   317 PRVNVVMYFFLYEEEFEAFFKEETPVTHLYFGRSVSRAILGRIGLNCPRL--IELVVCANGLLPL 379

  Fly   698 DAGLRALAESCPNLKKLSLRSCDMITDRGVQCIAYYCRGLQQLNIQD 744
            |:.|..:|:.|.||..|.|..|::.....|:.:....|.|.||:|.:
Mouse   380 DSELIRIAKHCKNLTSLGLSECEVSCSAFVEFVRLCGRRLTQLSIME 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	12/45 (27%)
		leucine-rich repeat	441..460	CDD:275381	4/18 (22%)
		AMN1	<451..595	CDD:187754	28/156 (18%)
		leucine-rich repeat	476..501	CDD:275381	1/24 (4%)
		leucine-rich repeat	502..521	CDD:275381	3/18 (17%)
		leucine-rich repeat	528..555	CDD:275381	5/26 (19%)
		leucine-rich repeat	556..581	CDD:275381	8/37 (22%)
		AMN1	577..746	CDD:187754	47/204 (23%)
		leucine-rich repeat	582..607	CDD:275381	7/24 (29%)
		leucine-rich repeat	608..633	CDD:275381	6/39 (15%)
		leucine-rich repeat	634..659	CDD:275381	7/25 (28%)
		leucine-rich repeat	660..685	CDD:275381	7/40 (18%)
		leucine-rich repeat	686..710	CDD:275381	6/27 (22%)
		leucine-rich repeat	711..735	CDD:275381	5/23 (22%)
		leucine-rich repeat	737..761	CDD:275381	4/8 (50%)
Fbxl21	NP_001333661.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820