DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Fbxl7 and K05C4.9

DIOPT Version :9

Sequence 1:NP_650512.1 Gene:Fbxl7 / 41935 FlyBaseID:FBgn0038385 Length:772 Species:Drosophila melanogaster
Sequence 2:NP_001362175.1 Gene:K05C4.9 / 187021 WormBaseID:WBGene00010585 Length:718 Species:Caenorhabditis elegans


Alignment Length:318 Identity:72/318 - (22%)
Similarity:110/318 - (34%) Gaps:82/318 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   498 RCPELTHLQLQTCVDITNQAL----VEALTKCSNLQHLDV-------------TGCSQVSSISPN 545
            |.|||. |.| |.||:.|..|    :|.|.....|:.|.:             ||.:.:.::..:
 Worm    54 RIPELV-LNL-TNVDLRNTTLCHNTIEMLRTQRTLESLALGSLLLIKKDYLCETGRTNIVALLKD 116

  Fly   546 PHMEPPRRLL----LQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCV 606
            ...|..|:.|    ::...|..|...|.:.     :..|.|..|.:...:...|..|:    .||
 Worm   117 ILNEKSRKRLRHLNIRGAGLIGCGWSDKLS-----ELFPSLKTLNVSNILFENDELLR----LCV 172

  Fly   607 SLKELSVSDC--LNITDF-GLYELAKL-GAALRYLSVAKCERVSD----AGLKVIARRCYK---- 659
            |...|.|.|.  .||... ||..|..| ..::|||..|....:.|    ..|||:.....|    
 Worm   173 SFPSLCVLDISGTNIASLHGLSNLKNLQELSIRYLEFANANNLVDLFQLTNLKVLDMSKSKNLET 237

  Fly   660 ----LRYLNARGCEAVSDDSITVLARSCPRLRALDIGKCDVSDAGLRALAESCPNLKKLSLRSCD 720
                ||::..              ..:.|.||.||....|:.:.....|....|||::::|..|.
 Worm   238 SKNVLRFVEC--------------GMNLPELRVLDCSGTDIDEELFAKLLSFLPNLQQIALMDCQ 288

  Fly   721 M---------------ITDRGVQCIAYYCRGLQQLNIQDCPVSI-----EGYRAVKKY 758
            :               ..:...|.:.||.:..:..::..|...|     |.|...|:|
 Worm   289 LKHAVFSTEIRVLNSATLETSFQTLNYYSKLKKSDSVMKCFQDIFFLLKEYYTQNKEY 346

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Fbxl7NP_650512.1 F-box-like 401..447 CDD:289689
leucine-rich repeat 441..460 CDD:275381
AMN1 <451..595 CDD:187754 26/117 (22%)
leucine-rich repeat 476..501 CDD:275381 1/2 (50%)
leucine-rich repeat 502..521 CDD:275381 8/22 (36%)
leucine-rich repeat 528..555 CDD:275381 6/39 (15%)
leucine-rich repeat 556..581 CDD:275381 3/24 (13%)
AMN1 577..746 CDD:187754 43/199 (22%)
leucine-rich repeat 582..607 CDD:275381 5/24 (21%)
leucine-rich repeat 608..633 CDD:275381 9/28 (32%)
leucine-rich repeat 634..659 CDD:275381 8/28 (29%)
leucine-rich repeat 660..685 CDD:275381 2/24 (8%)
leucine-rich repeat 686..710 CDD:275381 6/23 (26%)
leucine-rich repeat 711..735 CDD:275381 6/38 (16%)
leucine-rich repeat 737..761 CDD:275381 6/27 (22%)
K05C4.9NP_001362175.1 leucine-rich repeat 126..151 CDD:275381 4/29 (14%)
leucine-rich repeat 152..176 CDD:275381 7/27 (26%)
leucine-rich repeat 177..198 CDD:275378 8/20 (40%)
leucine-rich repeat 199..223 CDD:275378 6/23 (26%)
leucine-rich repeat 224..253 CDD:275378 6/42 (14%)
leucine-rich repeat 254..278 CDD:275378 6/23 (26%)
leucine-rich repeat 279..290 CDD:275378 3/10 (30%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C160162681
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.930

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