DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and si:ch73-173p19.1

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	XP_002660968.3	Gene:	si:ch73-173p19.1 / 100332407	ZFINID:	ZDB-GENE-130530-952	Length:	918	Species:	Danio rerio

Alignment Length:	818	Identity:	171/818 - (20%)
Similarity:	270/818 - (33%)	Gaps:	240/818 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 SDLECPLASLGRNSNAVRDHYHHPHPLSSSPLDPQAYKMMSRKSPNPGLEVAEALASRSS----T 71
            ::|.|.|.|||...||.......|   ..:|.||        .||.|.|.|.|...:...    .
Zfish   240 TELTCSLRSLGLTPNAALCIQTTP---PETPQDP--------PSPAPRLAVVEQPEAEPQEEPIA 293

  Fly    72 PPSDQAGASSTAAAAAVL-HMVQQKAATFELRGRHSRPTEQQTSYGAHSTASVGRHAKKSPELPA 135
            ||..:|||.........| |.:.::|..:........|....:.:.......|...|:....|..
Zfish   294 PPQVEAGALEEQEVPPPLPHQLWEEAVGYAGIPGVGPPLSGPSHFWGRGQKLVQGDAEDEEHLEN 358

  Fly   136 PASRNVAPVPQPRNFLTLEHVLQFGTQRPSWMHGNSADTEDSSDNNAGGGGAGSGSGGAGGRRRA 200
            ...:....|| |.||..|..:       |.:|                             ..||
Zfish   359 EEQQEEEVVP-PFNFEGLPRL-------PFFM-----------------------------ENRA 386

  Fly   201 QGGRCSVPTVLSSNGSGGNGAQYLLDKKMESLYLGNALRTLPLGAEASQFQNERYYLEDYSSGSG 265
            :||                     ||.:......||.||.:.....|.  .:|...|...:..:.
Zfish   387 RGG---------------------LDLRHHWPEQGNRLREVEPDDPAD--PDEGRALRGAAGQAA 428

  Fly   266 NERLPERLHHPRTSSPSETSGSDRYLLNRSSNSNHLHSKGQSLSDGLCNLGRFSPSLDQGYATLV 330
            .|||....||                                               |:.::|..
Zfish   429 VERLQRGAHH-----------------------------------------------DEQHSTHG 446

  Fly   331 SPSPTGHHSSGGAGNVTNSTTASGAGIMASSTPTTTPRRGASSNGLGGGAASAIGPPPWNRKGPF 395
            .|||                         ...|..|||..:..:.......|.:..|........
Zfish   447 QPSP-------------------------PKKPFKTPRVPSLCSMATRATVSLMTAPSMQYSSSL 486

  Fly   396 RC-GP-----LFDRLPDEAVVR-----------IFSWLDSC------ELCNVARVCRRFEHLAW- 436
            .| .|     |...:..|.::|           :..::.:|      ||....|.....:||::
Zfish   487 ACLTPELAELLLSHMARERLLRPRTLELFFGCPLQKFVLNCYPYTTNELLRQLRAFTCLKHLSFL 551

  Fly   437 -RPIL----WKVIS--LRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGCRISDKG--- 491
             .|::    ..|:|  .:.:|||.....|:  ...|.|...|.  .....:..|..::||.|
Zfish   552 NSPLITDAGLSVLSNLSKLQHLNLSSCSKL--TDSCLQHITGL--RSLTFLALDQTKVSDAGLLL 612

  Fly   492 -----------------------LQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQ--HL 531
                                   |::|....|:|..|.::.    |..:.|.||.:..|||  ||
Zfish   613 YLQSGSSALCQLSLNQTAITESTLRVLPASVPQLRMLSIKH----TKVSDVSALAELKNLQTLHL 673

  Fly   532 DVTGCSQ--VSSISPNPHMEPPRRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVT 594
            |.||..:  :..::.:|.:.   .|.|..:.:.|    .:..|:|:..  .:|..|.|.....||
Zfish   674 DGTGVQENSLQCLASHPSLS---ALSLAGIPVAD----GNHTLEIIAG--LRLTQLTLPGRHSVT 729

  Fly   595 DAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYK 659
            |:||.|: |....|.||.::|...:||.|:.:|:.: ..|:.||::..: |||:||:.:.|
Zfish   730 DSGLSFL-SRQTLLLELDLTDYTQLTDHGITQLSSM-TRLKKLSLSNTQ-VSDSGLQGLIR---- 787

  Fly   660 LRYLNARGCE--AVSDDSITVLARSCPRLRALDIGKCDVSDAGLRALAESCPNLKKLSLRSCDMI 722
            |:.|.....:  ||:...:..|....|.|:.:.:....|.|..:|.....||.|.||:| |...|
Zfish   788 LKELQELCLDRTAVTSRGVAALITHLPHLQVMGLASTQVGDTVIRRGLVHCPQLLKLNL-SRTRI 851

  Fly   723 TDRGVQCIAYYCR-GLQQLNIQDCPVSIEGYRAVKKYC 759
            ||:|::   :.|| .|.|:|:....|::.|...:...|
Zfish   852 TDQGLK---FLCRMQLSQVNLDGTGVTLVGIANLISAC 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	11/70 (16%)
		leucine-rich repeat	441..460	CDD:275381	6/20 (30%)
		AMN1	<451..595	CDD:187754	37/173 (21%)
		leucine-rich repeat	476..501	CDD:275381	6/50 (12%)
		leucine-rich repeat	502..521	CDD:275381	4/18 (22%)
		leucine-rich repeat	528..555	CDD:275381	8/30 (27%)
		leucine-rich repeat	556..581	CDD:275381	4/24 (17%)
		AMN1	577..746	CDD:187754	53/171 (31%)
		leucine-rich repeat	582..607	CDD:275381	10/24 (42%)
		leucine-rich repeat	608..633	CDD:275381	8/24 (33%)
		leucine-rich repeat	634..659	CDD:275381	9/24 (38%)
		leucine-rich repeat	660..685	CDD:275381	5/26 (19%)
		leucine-rich repeat	686..710	CDD:275381	5/23 (22%)
		leucine-rich repeat	711..735	CDD:275381	9/23 (39%)
		leucine-rich repeat	737..761	CDD:275381	6/23 (26%)
si:ch73-173p19.1	XP_002660968.3	UBA_like_SF	6..43	CDD:304366
		Nop25	116..>169	CDD:286843
		UBQ	187..260	CDD:294102	8/19 (42%)
		AMN1	523..701	CDD:187754	40/188 (21%)
		LRR	<524..710	CDD:227223	41/200 (21%)
		leucine-rich repeat	545..569	CDD:275381	5/23 (22%)
		leucine-rich repeat	570..594	CDD:275381	7/27 (26%)
		leucine-rich repeat	595..620	CDD:275381	4/24 (17%)
		leucine-rich repeat	621..645	CDD:275381	2/23 (9%)
		leucine-rich repeat	646..691	CDD:275381	14/48 (29%)
		leucine-rich repeat	692..766	CDD:275381	23/84 (27%)
		leucine-rich repeat	717..742	CDD:275381	10/25 (40%)
		AMN1	750..>888	CDD:187754	42/147 (29%)
		leucine-rich repeat	767..790	CDD:275381	10/27 (37%)
		leucine-rich repeat	791..815	CDD:275381	4/23 (17%)
		leucine-rich repeat	816..840	CDD:275381	5/23 (22%)
		leucine-rich repeat	841..863	CDD:275381	11/25 (44%)
		leucine-rich repeat	864..888	CDD:275381	6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900