DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and zgc:158376

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	NP_001093617.1	Gene:	zgc:158376 / 100101643	ZFINID:	ZDB-GENE-070720-8	Length:	818	Species:	Danio rerio

Alignment Length:	681	Identity:	148/681 - (21%)
Similarity:	235/681 - (34%)	Gaps:	170/681 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 ASRSSTPPSDQAG--ASSTAAAAAVLHMVQ-QKAATFELRGRHSRPTE------QQTSYGAHSTA 121
            :|.::.|.|...|  .|.||||:|:|...| |::...|...|..|..:      ..:|..:.|:.
Zfish   215 SSEANGPNSSSGGGHGSGTAAASALLSASQDQRSHQREKLERFKRMCQLLERVRDSSSSSSSSSE 279

  Fly   122 SVGRHAKKSPELPAPASRNVAPVPQPRNFLTLEHVLQFGTQRPSWMHGNSADTEDSSDNNAGGGG 186
            |.......||. |..||...:|.                       :|.||...:......|...
Zfish   280 SDSESDSDSPS-PIAASEPSSPA-----------------------YGGSARERNRRLAELGFSA 320

  Fly   187 AGSGSGGAGGRRRAQGGRCSVPTVLSSNGSGGNGAQYLLDKKMESLYLGNALRTLPLGAEASQFQ 251
            :....|.:......:|    |.......|.|....:..|:.:.|....|.........|.||...
Zfish   321 SEESEGESVAEVEVEG----VEEPQRRRGDGARVRRAALEPEPEEEEEGVGDHRAAPAAPASPQP 381

  Fly   252 NERYYLEDYSSGSGNERLPERLHHPRTSSPSETSGSD----RYLLNR----------SSNSNHLH 302
            |.:.....::..:|.:.||         |...|:|.|    |..:.|          |:..||.|
Zfish   382 NTQTPPFTHTHSTGTDGLP---------SSKRTNGQDARNGRTRVGREQQEKENAHSSAAPNHRH 437

  Fly   303 ---SKGQSLSDGLCNLGRFSPSLDQGYATLVSPSPTGHHSSG---GAGNVTNSTTASGAGIMA-- 359
               ::|..:..|    ||      ||.:.....|.:...|||   |:...||....:||.:.:
Zfish   438 VKPARGSKMRGG----GR------QGQSAASGKSSSAAVSSGTANGSTGFTNPAPLAGASLASHR 492

  Fly   360 ----------------SSTPTTTPRRGASSNGLGGGAASAIGPPPWNRKGPFRCGPLFDR----L 404
                            ||.|..:|.|.....      ...:.|||...:.  .|.||...    |
Zfish   493 SQQPRVVPPRSQLVKRSSVPVPSPPRPLQME------RHLVRPPPACPEP--HCLPLDSGATHVL 549

  Fly   405 PDEAVVRIFSWLDSCELCNVARVCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCGQSC 469
            |.:..:|:|..|:..:||...||||.:........||..|.|..:.......|..|.|:
Zfish   550 PRDVWLRVFQHLNQRQLCVCMRVCRTWSRWCCDKRLWTRIDLSRQRSITPPMLSSIIRR------ 608

  Fly   470 NGACPEVERVMLADG-CRISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDV 533
                   :.|.|..| ..||.|.|..|..|...|..|.|..|...:..||.:::..|  |:.||:
Zfish   609 -------QPVALNLGFTNISKKQLMWLINRLQGLLELNLSGCSWSSVSALCQSVCPC--LRLLDL 664

  Fly   534 TGCSQVSSISPNPHMEPP-------------------RRLLLQYLDLTDCMAIDDMGLKIVVKNC 579
            :....:........:.||                   ..|.|..|:::|.::      :::|:..
Zfish   665 SRVEDLKDSHLKELLAPPSNDTRSAHGENRGGRFQNVTELRLSGLEVSDGVS------RLLVRYL 723

  Fly   580 PQLVYLYLRRCIQVTDAGLKFVPSFCVSLKELSVSDCLNITDFGLYELAKLGAALRYLSVAKCER 644
            |.|..|.|.:|.|:||..:..:.|....|:|                      :|.::::|.|.:
Zfish   724 PHLTKLDLSQCSQITDQTIHTLTSALSPLRE----------------------SLTHINLAGCAK 766

  Fly   645 VSDAGLKVIARRCYKLRYLNARGCEAVSDDS 675
            |:|..:.:: |||..|:.|:.|.|..::.|:
Zfish   767 VTDQCVPLL-RRCASLQTLDLRSCLLLAPDA 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	14/49 (29%)
		leucine-rich repeat	441..460	CDD:275381	4/18 (22%)
		AMN1	<451..595	CDD:187754	35/163 (21%)
		leucine-rich repeat	476..501	CDD:275381	9/25 (36%)
		leucine-rich repeat	502..521	CDD:275381	6/18 (33%)
		leucine-rich repeat	528..555	CDD:275381	5/45 (11%)
		leucine-rich repeat	556..581	CDD:275381	4/24 (17%)
		AMN1	577..746	CDD:187754	24/99 (24%)
		leucine-rich repeat	582..607	CDD:275381	8/24 (33%)
		leucine-rich repeat	608..633	CDD:275381	2/24 (8%)
		leucine-rich repeat	634..659	CDD:275381	8/24 (33%)
		leucine-rich repeat	660..685	CDD:275381	5/16 (31%)
		leucine-rich repeat	686..710	CDD:275381
		leucine-rich repeat	711..735	CDD:275381
		leucine-rich repeat	737..761	CDD:275381
zgc:158376	NP_001093617.1	zf-CXXC	<21..55	CDD:251032
		PHD_FXL19	65..126	CDD:277115
		F-box-like	549..592	CDD:289689	14/42 (33%)
		leucine-rich repeat	559..583	CDD:275381	7/23 (30%)
		leucine-rich repeat	586..610	CDD:275381	6/36 (17%)
		AMN1	591..792	CDD:187754	53/244 (22%)
		leucine-rich repeat	611..633	CDD:275381	9/21 (43%)
		leucine-rich repeat	635..658	CDD:275381	6/22 (27%)
		leucine-rich repeat	659..700	CDD:275381	5/40 (13%)
		leucine-rich repeat	701..725	CDD:275381	5/29 (17%)
		leucine-rich repeat	726..755	CDD:275381	10/50 (20%)
		leucine-rich repeat	756..780	CDD:275381	8/24 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910