DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Fbxl7 and si:dkey-192l18.9

DIOPT Version :9

Sequence 1:	NP_650512.1	Gene:	Fbxl7 / 41935	FlyBaseID:	FBgn0038385	Length:	772	Species:	Drosophila melanogaster
Sequence 2:	XP_001344855.1	Gene:	si:dkey-192l18.9 / 100005961	ZFINID:	ZDB-GENE-120709-25	Length:	476	Species:	Danio rerio

Alignment Length:	489	Identity:	208/489 - (42%)
Similarity:	305/489 - (62%)	Gaps:	28/489 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly   295 SSNSNHLHSKGQSLSDGLCNLGRFSPSLDQGYATLVSPSPTGHHSSGGAGNVTNSTTASGAGIMA 359
            ::|.....|:|:         |..|.|.|...:|..:||.:..:::....:..:..|.|.|.|:.
Zfish     3 ANNGKQCESEGK---------GSSSISSDVSSSTEHTPSKSHKNAATSEDSDQSMRTPSPALILN 58

  Fly   360 SSTPTTTPRRGASSNGLGGGAASAIGPPPWNR----KGPFRCGPLFDRLPDEAVVRIFSWLDSCE 420
            .:.|.|.|....||.   |...:.|.|||..|    |.|...  |.|.|||..::.|.|:|.:..
Zfish    59 PNPPQTVPNGRESSL---GETVALIHPPPATRSKSTKPPHTA--LIDILPDPVLLHILSYLSTPH 118

  Fly   421 LCNVARVCRRFEHLAWRPILWKVISLRGEHLNGDKTLKMIFRQLCGQSCNGACPEVERVMLADGC 485
            ||..||||||:.:|:|.|.||..|.|.||.||.|:.||::..:|| |.....|..:|.| :|.||
Zfish   119 LCLCARVCRRWYNLSWDPRLWSTIRLNGELLNADRALKVLTHRLC-QDTPNVCLTLETV-VASGC 181

  Fly   486 -RISDKGLQLLTRRCPELTHLQLQTCVDITNQALVEALTKCSNLQHLDVTGCSQVSSISPNPH-- 547
             |:||:||:::.|.||||..|::..|.:::|.|:.:.::||.||:||||:||.:|:.||....
Zfish   182 RRLSDRGLRVIARCCPELRCLEVAGCYNVSNDAVFDVVSKCPNLEHLDVSGCPKVTCISLTEEGS 246

  Fly   548 -MEPP---RRLLLQYLDLTDCMAIDDMGLKIVVKNCPQLVYLYLRRCIQVTDAGLKFVPSFCVSL 608
             ...|   :::.|:||::|||::::|.|||.:..:||:|.:|||||||::||..|:.:...|.:|
Zfish   247 VQHTPLHGQQIGLRYLNMTDCVSLEDKGLKTIAIHCPRLTHLYLRRCIRITDESLRQLALHCTAL 311

  Fly   609 KELSVSDCLNITDFGLYELAKLGAALRYLSVAKCERVSDAGLKVIARRCYKLRYLNARGCEAVSD 673
            :|||:|||..:.||||.|:|:|...|||||||.|.|::|.||:.:||.|.:||||||||||.::|
Zfish   312 RELSLSDCHLVGDFGLREVARLEGRLRYLSVAHCMRITDVGLRYVARYCPRLRYLNARGCEGLTD 376

  Fly   674 DSITVLARSCPRLRALDIGKCD-VSDAGLRALAESCPNLKKLSLRSCDMITDRGVQCIAYYCRGL 737
            ..::.|||:|||||::|:|:|. ||||||..||..|..|::||||.|:.:|.||:..:|..|..|
Zfish   377 QGLSYLARNCPRLRSIDVGRCPLVSDAGLEVLAHCCKMLRRLSLRGCESLTGRGLMALAEGCPEL 441

  Fly   738 QQLNIQDCPVSIEGYRAVKKYCKRCIIEHTNPGF 771
            |.||:|:|.|..|..|.|:::|:||:||||.|.|
Zfish   442 QLLNVQECDVPPEALRLVRQHCRRCVIEHTIPAF 475

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Fbxl7	NP_650512.1	F-box-like	401..447	CDD:289689	21/45 (47%)
		leucine-rich repeat	441..460	CDD:275381	10/18 (56%)
		AMN1	<451..595	CDD:187754	62/150 (41%)
		leucine-rich repeat	476..501	CDD:275381	12/25 (48%)
		leucine-rich repeat	502..521	CDD:275381	5/18 (28%)
		leucine-rich repeat	528..555	CDD:275381	11/32 (34%)
		leucine-rich repeat	556..581	CDD:275381	11/24 (46%)
		AMN1	577..746	CDD:187754	90/169 (53%)
		leucine-rich repeat	582..607	CDD:275381	12/24 (50%)
		leucine-rich repeat	608..633	CDD:275381	14/24 (58%)
		leucine-rich repeat	634..659	CDD:275381	15/24 (63%)
		leucine-rich repeat	660..685	CDD:275381	15/24 (63%)
		leucine-rich repeat	686..710	CDD:275381	14/24 (58%)
		leucine-rich repeat	711..735	CDD:275381	10/23 (43%)
		leucine-rich repeat	737..761	CDD:275381	11/23 (48%)
si:dkey-192l18.9	XP_001344855.1	F-box-like	99..145	CDD:289689	21/45 (47%)
		leucine-rich repeat	114..138	CDD:275381	12/23 (52%)
		leucine-rich repeat	139..172	CDD:275381	14/33 (42%)
		leucine-rich repeat	173..198	CDD:275381	12/25 (48%)
		leucine-rich repeat	199..220	CDD:275381	5/20 (25%)
		LRR_CC	222..246	CDD:197685	12/23 (52%)
		leucine-rich repeat	225..258	CDD:275381	11/32 (34%)
		leucine-rich repeat	259..284	CDD:275381	11/24 (46%)
		AMN1	280..465	CDD:187754	96/184 (52%)
		leucine-rich repeat	285..310	CDD:275381	12/24 (50%)
		leucine-rich repeat	311..336	CDD:275381	14/24 (58%)
		leucine-rich repeat	337..362	CDD:275381	15/24 (63%)
		leucine-rich repeat	363..388	CDD:275381	15/24 (63%)
		leucine-rich repeat	389..414	CDD:275381	14/24 (58%)
		leucine-rich repeat	415..440	CDD:275381	11/24 (46%)
		leucine-rich repeat	441..465	CDD:275381	11/23 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	100	1.000	Domainoid score	I6965
eggNOG	1	0.900	-	-		E1_KOG1947
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	389	1.000	Inparanoid score	I1950
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1027299at2759
OrthoFinder	1	1.000	-	-		FOG0006053
OrthoInspector	1	1.000	-	-		otm24985
orthoMCL	1	0.900	-	-		OOG6_107386
Panther	1	1.100	-	-	O	PTHR13318
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2139
SonicParanoid	1	1.000	-	-		X4348
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.860