DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and Gucy1a2

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_076446.1	Gene:	Gucy1a2 / 66012	RGDID:	621655	Length:	730	Species:	Rattus norvegicus

Alignment Length:	220	Identity:	42/220 - (19%)
Similarity:	74/220 - (33%)	Gaps:	70/220 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 ALVLLPDDNMYQASLPRVLPI-------LKVAEQQIRSKSLIPSHIDFEWLAHDTKCDASLGVIK 101
            :|:..|.......:|.|.|..       .:.||:...:.|...|..|     |..|.:     |:
  Rat    93 SLLTAPSPQTIHMTLKRTLQYYEHQVIGYRDAEKNFHNISNRCSSAD-----HSNKEE-----IE 147

  Fly   102 AMDGIIKQCAQVI--------------FGPVCDYSLAAVSRITKYFNSQGTPLISVGGSTYDFEQ 152
            .:.||::..|.|:              |..:|             |:.....|.:||.:..||
  Rat   148 DVSGILRCTANVLGLKFQEIQERFGEEFFKIC-------------FDENERVLRAVGSTLQDF-- 197

  Fly   153 KKTDCNDEFYMLLRTGMLSFETI-------SELTINVMKRHNW--SHSIFYYERDGQRSVAGMHT 208
              .:..|.....:||......|:       .||....:|.|.:  .|::.:       ::.|
  Rat   198 --FNGFDALLEHIRTSFGKQATLESPSFLCKELPEGTLKLHYFHPHHTVGF-------AMLG--- 250

  Fly   209 CFLMMKSLGKQMRNENMTFAQFPLE 233
               |:|:.||::.:.|:...|...|
  Rat   251 ---MIKAAGKRIYHLNVEVEQIENE 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	41/218 (19%)
Gucy1a2	NP_076446.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..53
		HNOB	<157..268	CDD:285002	25/140 (18%)
		HNOBA	314..501	CDD:285003
		CYCc	483..672	CDD:214485
		Guanylate_cyc	512..696	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900