DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and npr1a

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001038402.1	Gene:	npr1a / 560653	ZFINID:	ZDB-GENE-060503-539	Length:	1067	Species:	Danio rerio

Alignment Length:	266	Identity:	60/266 - (22%)
Similarity:	108/266 - (40%)	Gaps:	45/266 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLVLLLVGLVFGPKDCVATCREEPARDCEAICDANGRNCTIRALVLLPDDNM-YQASLPRVLPI 64
            :.|::||.|:.||..:.......:|.   .....|:.:|.|:  .|:||..|. |..:.|||.|.
Zfish    11 LTLLVLLSGVSFGVVELEPVPENQPQ---SPSAHASQKNITL--AVILPLHNTEYPWAWPRVGPA 70

  Fly    65 LKVAEQQIRS--KSLIPSHIDFEWLAHDTK---CDASLGVIKAMDGIIKQCAQVIFGPVCDYSLA 124
            |..|.:::.|  ..|...|:...:.:.:.|   |..|:..:.|:|...........||.||||.:
Zfish    71 LYWALEKVNSDPNLLAGYHLQLVFNSSENKEGLCSDSVAPLVAVDLKFSYNPWAFIGPGCDYSSS 135

  Fly   125 AVSRITKYFNSQGTPLISVGGSTYDFEQKKTDCNDEFYMLLRTGMLSFETISELTINVMKRHNW- 188
            .|:|.|.::.   .|:|:.|.....|         ..|..:.....:.:.:.|..:.:.:...|
Zfish   136 PVARFTTHWE---VPMITSGARALGF---------NLYSSITNIGPTHKKLGEFVLRMHRHFGWD 188

  Fly   189 SHSIFYY--ERDGQRSVAGMHTCFLMMKSLGKQMRNENMTFAQF-------PLEPNLTNRTEEMR 244
            .|::..:  .::..|      .|:..::....|||.:|:|....       ||      |.:|:.
Zfish   189 KHAMLMFNDNKNDDR------PCYFAVEGPYTQMREDNITADDLVFNEDEEPL------RYDELL 241

  Fly   245 REIGNK 250
            |:|.:|
Zfish   242 RDISHK 247

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	46/210 (22%)
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380	51/226 (23%)
		ANF_receptor	66..421	CDD:279440	44/206 (21%)
		PK_GC-A_B	540..814	CDD:270944
		TyrKc	554..808	CDD:197581
		HNOBA	<823..868	CDD:285003
		CYCc	847..1032	CDD:214485
		Guanylate_cyc	874..1060	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810