DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and gucy1b2

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	XP_685297.5	Gene:	gucy1b2 / 557191	ZFINID:	ZDB-GENE-130530-664	Length:	757	Species:	Danio rerio

Alignment Length:	247	Identity:	52/247 - (21%)
Similarity:	87/247 - (35%)	Gaps:	49/247 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KDCVATCREEPARDCEAICDANGRNC--------TIRALVLLPDDNMYQASLPRVLPILKVAEQQ 71
            ||...|.|...||      .||.:.|        .:|::|:|...|:.|:..|.....|.:.||.
Zfish   210 KDKEETMRRMKAR------YANLQLCPRKRSPWELVRSIVMLGQGNLRQSFTPSYPKTLWIEEQA 268

  Fly    72 IRSKSLIPSHIDFEWLAHDTKCDASLGVIKAMDGIIKQCAQVIFGPVCDYSLAAVSRITKYFNSQ 136
            .  .:..|.||.|:                 .|.::|.....|...|.....|.: |:.:||...
Zfish   269 F--CNAFPFHIVFD-----------------SDLVVKHTGVNIQKFVPGLQTAGI-RLDEYFTIV 313

  Fly   137 GTPLISVGGSTYDFEQKKTDCNDEFYMLLRTGMLSFETISELTINVMKRHNWSHSI---FYYERD 198
            ...:|      ::.:..|...|.:|.:..|..||.....::.|:.:..:..|..|:   .|....
Zfish   314 HPEVI------FNIQSIKKFINSQFVLKTRREMLPEVQQNQPTLKLRGQMMWMESLNCMIYLCSP 372

  Fly   199 GQRSV-----AGMHTCFLMMKSLGKQMRNEN-MTFAQFPLEPNLTNRTEEMR 244
            ..||:     .|:|...:......:.:...| ...|:..|...|..:.||:|
Zfish   373 KLRSLQELEERGLHLADIAQHDTTRDLILLNQQRLAEIELSNQLERKKEELR 424

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	39/203 (19%)
gucy1b2	XP_685297.5	HNOB	2..163	CDD:285002
		CAF-1_p150	<166..277	CDD:288454	19/74 (26%)
		HNOBA	269..453	CDD:285003	34/182 (19%)
		CYCc	432..618	CDD:214485
		Guanylate_cyc	459..642	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900