DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and adcy1a

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001161821.1	Gene:	adcy1a / 557026	ZFINID:	ZDB-GENE-070705-302	Length:	1114	Species:	Danio rerio

Alignment Length:	230	Identity:	45/230 - (19%)
Similarity:	75/230 - (32%)	Gaps:	55/230 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 LVLLLVGLVFGPKDCVATC-----REEPARDCEAICDANG-----RNCTIRALVLLP------DD 51
            ||||:..:..|   ||.||     ....:.....:...||     |.|.....|.|.      ..
Zfish   672 LVLLMYSVTQG---CVVTCVPWSLEGNSSISMVTVVTVNGTGVGYRVCKYTPYVFLSCVMASLSV 733

  Fly    52 NMY--QASLPRV--LPILKVAEQQIRSKSLIPSHIDFEWLAHDTKCDASLGVIKAMDGIIKQCAQ 112
            .:|  .:|||::  |.:|.:....:...|.....:...:. |....|..|.::.....::..|.|
Zfish   734 ALYLRVSSLPKILLLLLLNILHTVVMETSGYRKAVGGGFF-HTHGYDPVLAMLLFSGALVLHCRQ 797

  Fly   113 VIFGPVCDYSLAAVSRITKYFNSQGTPLISVGGSTYDFEQKKTDCNDEFYMLL------------ 165
            :......||..|..:...:                .|.|:.|.|.....:.||
Zfish   798 LDLKLRLDYLWATQAEEER----------------DDMERVKLDNKRILFNLLPAHVAQHFLLSN 846

  Fly   166 -RTGMLSFETISELTINVMKRHNWSHSIFYYERDG 199
             |...|.:::.|::.:......|::.  ||.|.||
Zfish   847 PRNMDLYYQSYSQVGVLFASIPNFND--FYIELDG 879

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	32/177 (18%)
adcy1a	NP_001161821.1	AC_N	<154..285	CDD:292831
		CYCc	251..446	CDD:214485
		Guanylate_cyc	287..469	CDD:278633
		DUF1053	513..601	CDD:283888
		CYCc	819..1029	CDD:214485	14/63 (22%)
		Guanylate_cyc	852..1048	CDD:278633	8/30 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900