DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and NPR3

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001191304.1	Gene:	NPR3 / 4883	HGNCID:	7945	Length:	541	Species:	Homo sapiens

Alignment Length:	185	Identity:	48/185 - (25%)
Similarity:	88/185 - (47%)	Gaps:	29/185 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IRALVLLPDDNMYQASLPRVLPILKVAEQQIR----SKSLIPSHIDFEWLAHDTKCDASLGVIKA 102
            |..|||||.|:.|..||.||.|.::.|.:.:.    .:.|:|....|:....|:.|..     :|
Human    53 IEVLVLLPQDDSYLFSLTRVRPAIEYALRSVEGNGTGRRLLPPGTRFQVAYEDSDCGN-----RA 112

  Fly   103 MDGIIKQCA-------QVIFGPVCDYSLAAVSRITKYFNSQGTPLISVGGSTYDFEQKKTDCNDE 160
            :..::.:.|       .:|.||||:|:.|.|:|:..:::   .|::|.|.....|:.|    :.|
Human   113 LFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWD---LPMLSAGALAAGFQHK----DSE 170

  Fly   161 FYMLLRTGMLSFETISELTINVMKRHNWSHSIFYY-----ERDGQRSVAGMHTCF 210
            :..|.|... ::..:.|:.:.:.:.|:||.:...|     ||:...::.|:|..|
Human   171 YSHLTRVAP-AYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVF 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	46/181 (25%)
NPR3	NP_001191304.1	PBP1_NPR_C_like	54..446	CDD:107381	47/184 (26%)
		ANF_receptor	71..422	CDD:279440	38/167 (23%)
		TM_EphA1	476..507	CDD:214014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.876977	Normalized mean entropy	S7115
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR44755
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.820