DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and NPR2

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	XP_024303324.1	Gene:	NPR2 / 4882	HGNCID:	7944	Length:	1103	Species:	Homo sapiens

Alignment Length:	192	Identity:	48/192 - (25%)
Similarity:	83/192 - (43%)	Gaps:	38/192 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MLLVLLLVGLVFGPKDCVATCREEPARDCEAICDANGRNCTIRALVLLPDDNM-YQASLPRVLPI 64
            :|||..|.|.|..|                     ..||.|:  .|:||:.|: |..:.|||.|.
Human     7 LLLVAALAGGVRPP---------------------GARNLTL--AVVLPEHNLSYAWAWPRVGPA 48

  Fly    65 LKVAEQQIRSKSLIPSHIDFEWLAHDTK--CDASLGVIKAMDGIIKQCAQVIFGPVCDYSLAAVS 127
            :.:|.:.: .::|   .:|..:::.:.:  |...|..:.|:|..:.....::.||.|.|..|:|:
Human    49 VALAVEAL-GRAL---PVDLRFVSSELEGACSEYLAPLSAVDLKLYHDPDLLLGPGCVYPAASVA 109

  Fly   128 RITKYFNSQGTPLISVGGSTYDFEQKKTDCNDEFYMLLRTGMLSFETISELTINVMKRHNWS 189
            |...::.   .||::.|.....|..|    ||.:..|:|||. |...:.|..:.:....||:
Human   110 RFASHWR---LPLLTAGAVASGFSAK----NDHYRTLVRTGP-SAPKLGEFVVTLHGHFNWT 163

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	38/147 (26%)
NPR2	XP_024303324.1	Periplasmic_Binding_Protein_Type_1	26..421	CDD:324556	39/152 (26%)
		PK_GC-A_B	521..848	CDD:270944
		HNOBA	<857..902	CDD:311573
		CYCc	881..1065	CDD:214485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810