DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and GUCY2D

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_000171.1	Gene:	GUCY2D / 3000	HGNCID:	4689	Length:	1103	Species:	Homo sapiens

Alignment Length:	165	Identity:	31/165 - (18%)
Similarity:	56/165 - (33%)	Gaps:	66/165 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 IIKQC--AQVIFGPVCDYS---------------LAAVSRITKYFNSQGTPLISVGGSTYDFEQK 153
            ::|||  .|....|..|::               :.::.|:.:.::|....||.......:.|::
Human   783 LMKQCWAEQPELRPSMDHTFDLFKNINKGRKTNIIDSMLRMLEQYSSNLEDLIRERTEELELEKQ 847

  Fly   154 KTD--------------------CNDEFY---MLLRTGMLSFETISELT--INVMKRHN------ 187
            |||                    ...|::   .|..:.::.|.|||.::  |.|:...|
Human   848 KTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSDIVGFTTISAMSEPIEVVDLLNDLYTLF 912

  Fly   188 ----WSHSIFYYE--------------RDGQRSVA 204
                .||.::..|              |:|||..|
Human   913 DAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAA 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	31/165 (19%)
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594
		PK_GC-2D	536..811	CDD:270945	6/27 (22%)
		HNOBA	<820..865	CDD:369471	8/44 (18%)
		CYCc	846..1036	CDD:214485	20/102 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1103
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900