DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and GUCY2C

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_004954.2	Gene:	GUCY2C / 2984	HGNCID:	4688	Length:	1073	Species:	Homo sapiens

Alignment Length:	102	Identity:	28/102 - (27%)
Similarity:	44/102 - (43%)	Gaps:	15/102 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 VIFGPVCDYSLAAVSRITKYFNSQ-GTPLISVG--GSTYDFEQKKT----DCNDEFYMLL---RT 167
            |:.||.|.|     |....|.::: ..|:||.|  |.:.|:::..|    ......|.|:   :|
Human   118 VLIGPSCTY-----STFQMYLDTELSYPMISAGSFGLSCDYKETLTRLMSPARKLMYFLVNFWKT 177

  Fly   168 GMLSFETISELTINVMKRHNWSHSIFYYERDGQRSVA 204
            ..|.|:|.|..|..|.|....:...|:|....:.||:
Human   178 NDLPFKTYSWSTSYVYKNGTETEDCFWYLNALEASVS 214

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	28/102 (27%)
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364	28/102 (27%)
		PK_GC-C	480..750	CDD:270946
		Pkinase_Tyr	502..745	CDD:285015
		CYCc	788..979	CDD:214485
		Guanylate_cyc	815..1002	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900