DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and Gucy2c

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_037302.1	Gene:	Gucy2c / 25711	RGDID:	2771	Length:	1072	Species:	Rattus norvegicus

Alignment Length:	232	Identity:	46/232 - (19%)
Similarity:	91/232 - (39%)	Gaps:	56/232 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 NCTIRALVLLPDDNMYQASLPRVLPI----LKVAEQQIRSKSL-IPSHIDF---EWLAHDTKCDA 95
            |.|....||:.|::.|:..|..:...    |.:..:::|...| :..:..|   :.|.|.:. |.
  Rat    31 NGTYEISVLMMDNSAYKEPLQNLRDAVEEGLDIVRKRLREAELNVTVNATFIYSDGLIHKSG-DC 94

  Fly    96 SLGVIKAMDGIIKQCAQ------VIFGPVCDYSLAAVSRITKYFNSQ-GTPLISVG--GSTYDFE 151
            .....:.:| ::::..:      |:.||.|.|     |....|.::: ..|:||.|  |.:.|::
  Rat    95 RSSTCEGLD-LLREITRDRKMGCVLMGPSCTY-----STFQMYLDTELNYPMISAGSFGLSCDYK 153

  Fly   152 QKKT----DCNDEFYMLL---RTGMLSFETISELTINVMKRHNWSHSIFYYERDGQRSVAGMHTC 209
            :..|    ......|.|:   :.....|:|.|           |:.|..|  ::|...    ..|
  Rat   154 ETLTRILPPARKLMYFLVDFWKVNNAPFKTFS-----------WNSSYVY--KNGSEP----EDC 201

  Fly   210 FLMMKSL--GKQMRNENMTFAQFPLEPNLTNRTEEMR 244
            |..:.:|  |....:|.::|      .::..|:|:.:
  Rat   202 FWYLNALEAGVSYFSEVLSF------KDVLRRSEQFQ 232

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	43/220 (20%)
Gucy2c	NP_037302.1	Periplasmic_Binding_Protein_Type_1	34..414	CDD:299141	44/229 (19%)
		PKc_like	479..749	CDD:304357
		STYKc	501..744	CDD:214568
		CYCc	787..978	CDD:214485
		Guanylate_cyc	814..1001	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900