DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and ADCY4

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001185497.1	Gene:	ADCY4 / 196883	HGNCID:	235	Length:	1077	Species:	Homo sapiens

Alignment Length:	270	Identity:	53/270 - (19%)
Similarity:	84/270 - (31%)	Gaps:	114/270 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IRALVLLP--DDNMYQA------------SLPRVLPILKVAEQQ------IRSKSLIPSHIDFE- 85
            |.:|...|  .|..:||            .||..||::.|....      ..|.||. .|:.||
Human   679 ITSLFFFPTSSDCPFQAPNVSSMISNLSWELPGSLPLISVPYSMHCCTLGFLSCSLF-LHMSFEL 742

  Fly    86 -------WLA-------HD----TKC---DASLGVIKAMDGIIKQCAQVIFGPVC----DYSLAA 125
                   |||       |.    ::|   ...||.:.:..|::|:  ..:.|.:.    .::|..
Human   743 KLLLLLLWLAASCSLFLHSHAWLSECLIVRLYLGPLDSRPGVLKE--PKLMGAISFFIFFFTLLV 805

  Fly   126 VSRITKYFNSQGTPLISVGGSTYDFEQKKTDCNDEFYMLLRTGMLSFETISELT----INVMKRH 186
            ::|..:|:            ...||..||.         ||......||:..||    .||:..|
Human   806 LARQNEYY------------CRLDFLWKKK---------LRQEREETETMENLTRLLLENVLPAH 849

  Fly   187 NWSHSIFYYERDGQRSVAGMHTCFLMMKSLGKQMRNENM----------------TFAQFPLEPN 235
                                    :..:.:|:..|||::                .|.:|..|.|
Human   850 ------------------------VAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESN 890

  Fly   236 LTNRTEEMRR 245
            :.:...|..|
Human   891 INHEGLECLR 900

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	49/260 (19%)
ADCY4	NP_001185497.1	AC_N	<115..246	CDD:292831
		CYCc	219..422	CDD:214485
		Guanylate_cyc	264..418	CDD:278633
		DUF1053	479..583	CDD:283888
		CYCc	827..1042	CDD:214485	17/98 (17%)
		Guanylate_cyc	864..1063	CDD:278633	6/37 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900