DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and gcy-21

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001364740.1	Gene:	gcy-21 / 191651	WormBaseID:	WBGene00001546	Length:	1163	Species:	Caenorhabditis elegans

Alignment Length:	243	Identity:	48/243 - (19%)
Similarity:	86/243 - (35%)	Gaps:	78/243 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 EEPARDCEAICDANGRNCTIRALV--------LLPDDNMYQASLPRVLPILKVAEQQIRSKSLIP 79
            ::||:.|...|     |.|:...:        ||.|...|.|....  ..|.:      ..::..
Worm   335 KKPAKMCPPYC-----NTTVSEKITPRWDRIKLLFDSIQYLADATN--DALNI------GANIYQ 386

  Fly    80 SHIDFEWLAHDTKCDASLGVIKAMDGIIKQCAQVIFGPVC---------------DYSLAAVSRI 129
            |.|.:|:|. ..|.|:..||.:.:||         :|.:.               .|||...:|:
Worm   387 SDIFYEYLI-SRKIDSVTGVTEFIDG---------YGAIVGSIQIYYHFSSSSHNSYSLFPCARL 441

  Fly   130 TKYFNSQGTPLISV-------GGSTYDFEQKKT------------DC----NDEFYMLLRTGMLS 171
                 :|.:.|.:|       .|.:.||..|..            :|    |:.|.:::..|:..
Worm   442 -----AQSSLLNTVWSLTDYSEGLSIDFVNKSAPKDTPVCGFYGENCGPPANNTFIIVISVGVAV 501

  Fly   172 FETISELTINVMKRHNWS---HSIFYYERDGQRSVAGMHTCFLMMKSL 216
            ...::.....:.||:.:.   ||:|:. .|..:.:...||..:..:||
Worm   502 LIGLAIAAAFLYKRYRYERRLHSLFFM-IDRNQIILKKHTNLMSQQSL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	42/220 (19%)
gcy-21	NP_001364740.1	Periplasmic_Binding_Protein_type1	58..422	CDD:415822	23/109 (21%)
		PK_GC	612..881	CDD:270894
		HNOBA	<890..938	CDD:400168
		Guanylate_cyc	944..1130	CDD:306677
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900