DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and gcy-17

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001293327.1	Gene:	gcy-17 / 191649	WormBaseID:	WBGene00001542	Length:	1088	Species:	Caenorhabditis elegans

Alignment Length:	232	Identity:	54/232 - (23%)
Similarity:	93/232 - (40%)	Gaps:	54/232 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 NCTIRALV---LLPDDNM--------YQASLPRVLPILKVAEQQIRSKSLIPSHIDFEWLAHDTK 92
            ||..|..:   ||...|:        |:.|...||    |.:.:||...::.. .|||:|....:
Worm    17 NCQARRTIKVGLLFVQNVSSLQVGIGYRTSAAAVL----VTKNKIREDHVLDG-FDFEFLWDFDE 76

  Fly    93 CDASLGVIKAMDGIIKQCAQVIFGPVCDYSLAAVSRITKYFNSQGTPLISVGGSTYDFEQKKTDC 157
            |:..||..|.:|.:..:...|||||.|.......|.:..|:|   .|:...|.::   .::.||.
Worm    77 CNEILGAGKTVDLLEVKKVDVIFGPTCSRPALISSALATYYN---IPIFEWGLTS---TRQLTDV 135

  Fly   158 NDEFYMLLRTGMLSFETISELTINVMKRHNWSHSIFYYERDGQ-----------RSVAGMHTCFL 211
            . .|...|...:.|: :::...:..:|:..|:..:|.|..||.           ::||..|
Worm   136 K-RFPTTLPFSVNSY-SLAMAILGTLKQFQWTEFVFLYCNDGDDEKCESLKDDVQTVASAH---- 194

  Fly   212 MMKSLGKQMRNENMTFA-QFPLEPNLTNRTEEMRREI 247
                       |.::.| .|.::   :.:.|:||..|
Worm   195 -----------EELSLAYTFRIQ---SKKLEDMRAAI 217

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	47/217 (22%)
gcy-17	NP_001293327.1	Periplasmic_Binding_Protein_Type_1	25..404	CDD:299141	51/224 (23%)
		ANF_receptor	47..398	CDD:279440	46/202 (23%)
		PKc_like	539..808	CDD:304357
		Pkinase	567..803	CDD:278497
		HNOBA	<824..867	CDD:285003
		CYCc	846..1038	CDD:214485
		Guanylate_cyc	873..1060	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810