DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and gcy-4

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_496218.2	Gene:	gcy-4 / 191642	WormBaseID:	WBGene00001531	Length:	1136	Species:	Caenorhabditis elegans

Alignment Length:	159	Identity:	30/159 - (18%)
Similarity:	73/159 - (45%)	Gaps:	17/159 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    67 VAEQQIRSKSLIPSHIDFEWLAHDTKCDASLGVIKAMDGIIKQCAQVIFGPVCDYSLAAVSRITK 131
            :|.|.::|...: .:.|||:....|:||.:..|...::.:......||.||.|..:|..:..::.
Worm    54 LALQYLKSHGYM-LNFDFEFHVEYTECDLANTVRAGLNFMKTNNYDVIIGPPCAPALKMMGTLST 117

  Fly   132 YFNSQGTPLISVGGSTYDFEQKKTDCNDEFYMLLRTGMLSFETISELTINVMKRHNWSH-SIFYY 195
            .:..   |::..|   :..|.:.:|.|.  :..:.:.:.|.:|:..:|..:::.:.|.. ::.|:
Worm   118 IYKK---PVLGWG---FVSESEISDMNR--FPFVASVLPSTKTLGVVTSKLLEIYGWDRVALLYF 174

  Fly   196 ERDGQRSVAGMHTCFLMMKSLGKQMRNEN 224
            :.:       :..|..::..:.|.:.||:
Worm   175 KNE-------LDYCSSVVNDVEKSLYNES 196

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	30/159 (19%)
gcy-4	NP_496218.2	PBP1_NPR_GC_like	29..457	CDD:107347	30/159 (19%)
		ANF_receptor	49..423	CDD:279440	30/159 (19%)
		PKc_like	558..819	CDD:304357
		HNOBA	<834..876	CDD:285003
		CYCc	855..1047	CDD:214485
		Guanylate_cyc	882..1070	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810