DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and phlp-2

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001337270.1	Gene:	phlp-2 / 185690	WormBaseID:	WBGene00009647	Length:	1126	Species:	Caenorhabditis elegans

Alignment Length:	247	Identity:	46/247 - (18%)
Similarity:	76/247 - (30%)	Gaps:	94/247 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 RALVLLPDDNMYQA--SLPRVLPILKVAEQQIRSKSLIPSHIDFEWLAHDTKCDASLGVIKAMDG 105
            |||.|..||..|..  ..|.:|.......||:...    :|:|        ..|..|.:|.  :.
Worm   196 RALRLKDDDVCYLIIFQRPNILEAWLTRAQQVEKS----NHVD--------ASDEQLTLIP--EQ 246

  Fly   106 IIKQCAQV----------IFGPVCDYSLAAVSRITKYFNSQGTPLISVG---------------- 144
            |:...|:|          |..|..:.|:|.:..|...:......:|.:.
Worm   247 ILNNEARVQILNLRRNSLISRPPTEKSMAPLGYIDDLYRVHSLQVIDLSANQILSFPIQLTLLSH 311

  Fly   145 ------GSTYDFEQKKTDCNDE---FYMLLRTGMLSF--ETISELTINVMKRHNWSHSIFYYERD 198
                  .|.| .....::|::.   .|:.|....|..  ::||||
Worm   312 LRQLNLSSNY-ISSVPSECSNMRRLQYLNLSNNQLDTLPDSISEL-------------------- 355

  Fly   199 GQRSVAGMHTCFLMMKSLGKQMRNENMTFAQF-PLEPNLTNRTEEMRREIGN 249
                               :.:::.:::|.|| .:.|.|.:.|.||.|..||
Worm   356 -------------------QNLQSLDISFNQFSQIPPCLFHLTLEMWRLAGN 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	37/234 (16%)
phlp-2	NP_001337270.1	leucine-rich repeat	232..253	CDD:275380	6/30 (20%)
		leucine-rich repeat	254..288	CDD:275380	6/33 (18%)
		PLN00113	283..>718	CDD:331614	22/146 (15%)
		leucine-rich repeat	289..311	CDD:275380	1/21 (5%)
		leucine-rich repeat	312..334	CDD:275380	3/22 (14%)
		leucine-rich repeat	335..357	CDD:275380	7/60 (12%)
		leucine-rich repeat	358..379	CDD:275380	5/20 (25%)
		leucine-rich repeat	380..440	CDD:275380	5/9 (56%)
		leucine-rich repeat	441..485	CDD:275380
		leucine-rich repeat	486..508	CDD:275380
		leucine-rich repeat	509..534	CDD:275380
		leucine-rich repeat	554..577	CDD:275380
		leucine-rich repeat	578..602	CDD:275380
		leucine-rich repeat	603..625	CDD:275380
		leucine-rich repeat	626..649	CDD:275380
		leucine-rich repeat	650..672	CDD:275380
		leucine-rich repeat	673..694	CDD:275380
		PP2Cc	754..985	CDD:214625
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900