DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and Npr3

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_032754.2	Gene:	Npr3 / 18162	MGIID:	97373	Length:	536	Species:	Mus musculus

Alignment Length:	185	Identity:	49/185 - (26%)
Similarity:	88/185 - (47%)	Gaps:	29/185 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 IRALVLLPDDNMYQASLPRVLPILKVAEQQIR----SKSLIPSHIDFEWLAHDTKCDASLGVIKA 102
            |..|||||.|:.|..||.||.|.::.|.:.:.    .:.|:|....|:....|:.|..     :|
Mouse    48 IEVLVLLPRDDSYLFSLARVRPAIEYALRSVEGNGTGRKLLPPGTRFQVAYEDSDCGN-----RA 107

  Fly   103 MDGIIKQCA-------QVIFGPVCDYSLAAVSRITKYFNSQGTPLISVGGSTYDFEQKKTDCNDE 160
            :..::.:.|       .:|.||||:|:.|.|:|:..:::   .|::|.|.....|:.|.|    |
Mouse   108 LFSLVDRVAAARGAKPDLILGPVCEYAAAPVARLASHWD---LPMLSAGALAAGFQHKDT----E 165

  Fly   161 FYMLLRTGMLSFETISELTINVMKRHNWSHSIFYY-----ERDGQRSVAGMHTCF 210
            :..|.|... ::..:.|:.:.:.:.|:||.:...|     ||:...::.|:|..|
Mouse   166 YSHLTRVAP-AYAKMGEMMLALFRHHHWSRAALVYSDDKLERNCYFTLEGVHEVF 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	47/181 (26%)
Npr3	NP_032754.2	PBP1_NPR_C_like	49..440	CDD:107381	48/184 (26%)
		ANF_receptor	66..419	CDD:279440	39/167 (23%)
		TM_EphA1	471..502	CDD:214014
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.876977	Normalized mean entropy	S7115
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR44755
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	5	4.820