DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and gcy-8

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_501324.2	Gene:	gcy-8 / 177584	WormBaseID:	WBGene00001535	Length:	1152	Species:	Caenorhabditis elegans

Alignment Length:	142	Identity:	32/142 - (22%)
Similarity:	66/142 - (46%)	Gaps:	17/142 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 ILKVAEQQIRSKSLIPSHIDFEWLAHDTKCDASL-GVIKAMDGIIKQCAQVIFGPVCDYSLAAVS 127
            ||:|:.:.::::.::...:|.| :...|.|..|. ||..|.|....|..:...||.|:..:.||:
Worm    86 ILEVSHKALQAEGILDDDLDVE-IISQTGCGESYEGVAVAADMYHLQKVKAFIGPYCNAEMDAVA 149

  Fly   128 RITKYFNSQGTPLISVGGSTYDFEQKKTDCNDEFYMLLRTGMLSFETISELTINVMKRHNWSH-- 190
            |:..::|   .|:|....::.:...|     :.:..|.|..:.:..:|:|.|..:::.:.|:.
Worm   150 RMAAFWN---IPIIGYMAASNNLADK-----NAYPTLARISLRTTNSIAEATCAMLRHYGWNKVA 206

  Fly   191 -----SIFYYER 197
                 .|..|:|
Worm   207 IITNTGILAYDR 218

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	32/142 (23%)
gcy-8	NP_501324.2	ANF_receptor	87..442	CDD:279440	31/141 (22%)
		Periplasmic_Binding_Protein_Type_1	94..434	CDD:299141	29/134 (22%)
		PKc_like	558..850	CDD:304357
		HNOBA	<866..912	CDD:285003
		CYCc	891..1084	CDD:214485
		Guanylate_cyc	918..1105	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810