DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and Gucy2c

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_001120790.1	Gene:	Gucy2c / 14917	MGIID:	106903	Length:	1072	Species:	Mus musculus

Alignment Length:	245	Identity:	53/245 - (21%)
Similarity:	97/245 - (39%)	Gaps:	57/245 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 NGRNCTIRALVLLPDDNMYQASLPRVLPI----LKVAEQQIRSKSL-IPSHIDF---EWLAHDT- 91
            |.||.:....||:.|::.|:..:..:...    |.:..:::|...| :..:..|   :.|.|.:
Mouse    29 NCRNGSYEISVLMMDNSAYKEPMQNLREAVEEGLDIVRKRLREADLNVTVNATFIYSDGLIHKSG 93

  Fly    92 KCDAS----LGVIKAMDGIIKQ-CAQVIFGPVCDYSLAAVSRITKYFNSQ-GTPLISVG--GSTY 148
            .|.:|    |.:::.:....|. ||  :.||.|.|     |....|.::: ..|:||.|  |.:.
Mouse    94 DCRSSTCEGLDLLREITRDHKMGCA--LMGPSCTY-----STFQMYLDTELNYPMISAGSYGLSC 151

  Fly   149 DFEQKKT----DCNDEFYMLL---RTGMLSFETISELTINVMKRHNWSHSIFYYERDGQRSVAGM 206
            |:::..|    ......|.|:   :....||:..|           |:.|..|  ::|...
Mouse   152 DYKETLTRILPPARKLMYFLVDFWKVNNASFKPFS-----------WNSSYVY--KNGSEP---- 199

  Fly   207 HTCFLMMKSL--GKQMRNENMTFAQFPLEPNLTNRTEEMRREIGNKHASK 254
            ..||..:.:|  |....:|.:.|      .::..|:|:. :||...|..|
Mouse   200 EDCFWYLNALEAGVSYFSEVLNF------KDVLRRSEQF-QEILTGHNRK 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	45/220 (20%)
Gucy2c	NP_001120790.1	Periplasmic_Binding_Protein_Type_1	35..415	CDD:299141	50/239 (21%)
		PKc_like	480..749	CDD:304357
		STYKc	502..744	CDD:214568
		CYCc	787..978	CDD:214485
		Guanylate_cyc	814..1001	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900