DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and ADCY9

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	XP_005255136.1	Gene:	ADCY9 / 115	HGNCID:	240	Length:	1372	Species:	Homo sapiens

Alignment Length:	167	Identity:	36/167 - (21%)
Similarity:	60/167 - (35%)	Gaps:	41/167 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 FEWLAHDTKCD--ASLGVIKAMDGIIKQCAQVIFG---PVCDYS-------LAAVSRITKYFNSQ 136
            |:.|..:|||:  ::||          .|...:.|   |..|::       |..:..|.::...:
Human   426 FDRLCEETKCEKISTLG----------DCYYCVAGCPEPRADHAYCCIEMGLGMIKAIEQFCQEK 480

  Fly   137 ------------GTPLISV-GGSTYDFEQKKTDCNDEFYMLLRTGMLSFETISELTINVMKRHNW 188
                        ||.|..: |...:.|:....|.| ...::.:.|:.....|||.|...:.....
Human   481 KEMVNMRVGVHTGTVLCGILGMRRFKFDVWSNDVN-LANLMEQLGVAGKVHISEATAKYLDDRYE 544

  Fly   189 SHSIFYYERDGQRSVA----GMHTCFLMMKSLGKQMR 221
            .......||.||..||    |:.| :|:.....|:.|
Human   545 MEDGKVIERLGQSVVADQLKGLKT-YLISGQRAKESR 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	36/167 (22%)
ADCY9	XP_005255136.1	DUF2339	<118..>301	CDD:287113
		CYCc	326..544	CDD:214485	25/128 (20%)
		Guanylate_cyc	385..573	CDD:278633	34/158 (22%)
		CYCc	1043..1243	CDD:214485
		Guanylate_cyc	1069..1260	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900