DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14877 and ADCY2

DIOPT Version :9

Sequence 1:	NP_650507.1	Gene:	CG14877 / 41929	FlyBaseID:	FBgn0038380	Length:	254	Species:	Drosophila melanogaster
Sequence 2:	NP_065433.2	Gene:	ADCY2 / 108	HGNCID:	233	Length:	1091	Species:	Homo sapiens

Alignment Length:	148	Identity:	26/148 - (17%)
Similarity:	53/148 - (35%)	Gaps:	44/148 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 KSLIPSHIDFEWLAHDTKCDASLGVIKAMDGIIKQ---CAQVIFGPVCDYS-------------- 122
            ::::|:|:...:||...|          .:.:..|   |..|:|..:.|:.
Human   857 ENVLPAHVAEHFLARSLK----------NEELYHQSYDCVCVMFASIPDFKEFYTESDVNKEGLE 911

  Fly   123 -LAAVSRITKYFNS-------QGTPLISVGGSTYDF--------EQKKTDCNDEFYMLLRTGMLS 171
             |..::.|...|:.       .|...|...||||..        .|:.:...:..||.:.| |:.
Human   912 CLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHSQEPERQYMHIGT-MVE 975

  Fly   172 FETISELTINVMKRHNWS 189
            |.......::.:.:|:::
Human   976 FAFALVGKLDAINKHSFN 993

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14877	NP_650507.1	Periplasmic_Binding_Protein_Type_1	46..>241	CDD:299141	26/148 (18%)
ADCY2	NP_065433.2	AC_N	<33..260	CDD:292831
		CYCc	236..439	CDD:214485
		Guanylate_cyc	281..465	CDD:278633
		DUF1053	495..599	CDD:283888
		CYCc	848..1056	CDD:214485	26/148 (18%)
		Guanylate_cyc	878..1077	CDD:278633	21/117 (18%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	905..922		2/16 (13%)
		Interaction with GNAS. /evidence=ECO:0000250\|UniProtKB:P26769	990..993		1/2 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900