DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and CYR1

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_012529.3	Gene:	CYR1 / 853452	SGDID:	S000003542	Length:	2026	Species:	Saccharomyces cerevisiae

Alignment Length:	1610	Identity:	287/1610 - (17%)
Similarity:	517/1610 - (32%)	Gaps:	565/1610 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 EHSFKTPETKNSHKSQSTELVQHFPSLPMPDHRRLGARRQLVFVALLPSVESDNKNDC------- 103
            |...||| ..|..||.:.:......::..||    ||:..    .||...|.|::.:|
Yeast   612 EQDNKTP-ILNKTKSYTKKFTSSSVNMNSPD----GAQSS----GLLLQDEKDDEVECQLEHYYK 667

  Fly   104 ----IMPKVLPVLELAIRHVQRMGFVGGSHFDIQLISR-DTFCSSKYGPIGFFEIYTQWPEVNAV 163
                :.||                    .|:.|::.:. |||.:....|....|...  |.:...
Yeast   668 DFSDLDPK--------------------RHYAIRIFNTDDTFTTLSCTPATTVEEII--PALKRK 710

  Fly   164 FGLPCE-------------YVLAPISRYADVWQVPVLTTGGNAKE-----------------FNK 198
            |.:..:             .:|.|.|:...:.:..:|..|....:                 |:.
Yeast   711 FNITAQGNFQISLKVGKLSKILRPTSKPILIERKLLLLNGYRKSDPLHIMGIEDLSFVFKFLFHP 775

  Fly   199 KSESYST------LTRLKGAQVNNLGNVVRAILNSFNWTRTALI-YQN----ENAKVKGNSVCFL 252
            .:.|:.|      :.|.:...|:         |.:.:.|...:| ||:    |:..|..|:..||
Yeast   776 VTPSHFTPEQEQRIMRSEFVHVD---------LRNMDLTTPPIIFYQHTSEIESLDVSNNANIFL 831

  Fly   253 CLAAIHDTIEEHSVYQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIM------LTA 311
            .|..|..:|:..|:..:....|.: .::||:..|.|:::.:...:...|.||.::.      |..
Yeast   832 PLEFIESSIKLLSLRMVNIRASKF-PSNITKAYKLVSLELQRNFIRKVPNSIMKLSNLTILNLQC 895

  Fly   312 EELNMIDSGEYVFINIEL---------------------------FSRVQYLTSQPWYDKNDTDL 349
            .||..:.:|.....|::|                           ::::|.|.....|......:
Yeast   896 NELESLPAGFVELKNLQLLDLSSNKFMHYPEVINYCTNLLQIDLSYNKIQSLPQSTKYLVKLAKM 960

  Fly   350 NNERAQKAYTAMLT-VTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLY 413
            |....:..:...|: :|..:..:..|.|:|: ||..|:...|...:||.      .|.|:..|..
Yeast   961 NLSHNKLNFIGDLSEMTDLRTLNLRYNRISS-IKTNASNLQNLFLTDNR------ISNFEDTLPK 1018

  Fly   414 ANALNESIREDP-----------------------------TMLTR-------PINGTDMVR--- 439
            ..||  .|:|:|                             .:||:       .:|..::.|
Yeast  1019 LRAL--EIQENPITSISFKDFYPKNMTSLTLNKAQLSSIPGELLTKLSFLEKLELNQNNLTRLPQ 1081

  Fly   440 ---RMWNRSFTGITGNV---------------TIDANG-------DRLSAYSLLDMNPTTGRF-- 477
               ::....|..:..|.               |:|.:.       |.:....|..:|.::..|
Yeast  1082 EISKLTKLVFLSVARNKLEYIPPELSQLKSLRTLDLHSNNIRDFVDGMENLELTSLNISSNAFGN 1146

  Fly   478 -EIVAHFLHNRLEF--EANKEIHW--AGDREEAPPDRPICGYDGALCP-DNSLPGYAILSIVLGT 536
             .:...|.|| :.:  :.:|.:.:  |.|.:          :|.|:.| .|......:|::
Yeast  1147 SSLENSFYHN-MSYGSKLSKSLMFFIAADNQ----------FDDAMWPLFNCFVNLKVLNL---- 1196

  Fly   537 MVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRG------SFHSLVKQSSQLT 595
                       .|.::   ::::.|    .||.:     .|..|.|      |..:::|.||..|
Yeast  1197 -----------SYNNF---SDVSHM----KLESI-----TELYLSGNKLTTLSGDTVLKWSSLKT 1238

  Fly   596 LMSEDMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQ-GLLTRSLMLELKRMKDLQHDHLVKFY 659
            ||      :|.::.:.:|..:...|::::..|..:.:: .:.........:..|:|::   :.|.
Yeast  1239 LM------LNSNQMLSLPAELSNLSQLSVFDVGANQLKYNISNYHYDWNWRNNKELKY---LNFS 1294

  Fly   660 GACLDQRRSFLLTEYCPKGSLQDILENEQFQL----------------DWMFRLSLMHDIVRGMQ 708
            |....:.:||:..:.  ...|.|:....|.::                :..|||.....|:.||:
Yeast  1295 GNRRFEIKSFISHDI--DADLSDLTVLPQLKVLGLMDVTLNTTKVPDENVNFRLRTTASIINGMR 1357

  Fly   709 -----------FLHSSDI---RSHGNLKSSNCVV---DSRFVLKITDFGLHTLRRTRFD------ 750
                       ::.|.|:   |..||  ...|::   ||:  .:..|:| |.:.|...|
Yeast  1358 YGVADTLGQRDYVSSRDVTFERFRGN--DDECLLCLHDSK--NQNADYG-HNISRIVRDIYDKIL 1417

  Fly   751 ---LESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEG-----TQKGDV----YA---FGIIVHE 800
               ||..|...:.:      :.||.....::.|:...|     ....||    ||   .|.....
Yeast  1418 IRQLERYGDETDDN------IKTALRFSFLQLNKEINGMLNSVDNGADVANLSYADLLSGACSTV 1476

  Fly   801 ITTRQGPFY---LGRC--AYEKSPQEIIELVKGYNPHRMQKPFR--------------------- 839
            |..|....:   ||.|  ...|:..:...|.|.:.|.:.::..|
Yeast  1477 IYIRGKKLFAANLGDCMAILSKNNGDYQTLTKQHLPTKREEYERIRISGGYVNNGKLDGVVDVSR 1541

  Fly   840 --------PELEPNGD------TKADINGII--RRCWAEDPAERPDFNTLKSMIRRFNKD--NET 886
                    |.:..:.|      ||||...|:  .:.|     |..|.:|:..:.|..:.|  ...
Yeast  1542 AVGFFDLLPHIHASPDISVVTLTKADEMLIVATHKLW-----EYMDVDTVCDIARENSTDPLRAA 1601

  Fly   887 GNIVDNLLKR----------MELYAN---------NLEELVEERTQDYHEEKKKCEKLLYQLLPQ 932
            ..:.|:.:..          :.||.|         |...|:..|:.   .|.....:|
Yeast  1602 AELKDHAMAYGCTENITILCLALYENIQQQNRFTLNKNSLMTRRST---FEDTTLRRL------- 1656

  Fly   933 SVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLY--TCFDSIVENFDV- 994
                     ||.::.....:.:.|:||...|             ||.:|:  ....:|..:.|:
Yeast  1657 ---------QPEISPPTGNLAMVFTDIKSST-------------FLWELFPNAMRTAIKTHNDIM 1699

  Fly   995 ---------YKVETIGDAYMV-----VSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPE-- 1043
                     |:|:|.|||:||     .|||         .....:.|.||:|       ..||
Yeast  1700 RRQLRIYGGYEVKTEGDAFMVAFPTPTSGL---------TWCLSVQLKLLDA-------QWPEEI 1748

  Fly  1044 ----------DR--------LKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALK 1090
                      ||        |.:|:|:|.| |....:.|...|....|..||.|:|::...:..:
Yeast  1749 TSVQDGCQVTDRNGNIIYQGLSVRMGIHWG-CPVPELDLVTQRMDYLGPMVNKAARVQGVADGGQ 1812

  Fly  1091 IHISETTKEALDEFGTFVTTRRGFVPMKGK--------GEMLTYWLEGEVPRPNSL--------- 1138
            |.:|   .:...||...:......|  |||        .|::...||.|:....|:
Yeast  1813 IAMS---SDFYSEFNKIMKYHERVV--KGKESLKEVYGEEIIGEVLEREIAMLESIGWAFFDFGE 1872

  Fly  1139 -------------ISPSKLMLTRRSSLKQPQRSQSHNLHKQYSELVVASPPPQLPPPAIALPPPP 1190
                         |:..|::.:|.....:.::|      |..:|.::.
Yeast  1873 HKLKGLETKELVTIAYPKILASRHEFASEDEQS------KLINETMLF----------------- 1914

  Fly  1191 SPSKDSPNLRV-KRKISSSSPKLNGGGFDY-HKTENHYLDTAAAAQRNCDIYSSRSLRD------ 1247
                   .||| ..::.|....|:||..:. .:||..|:......:..  |..|.|.:|
Yeast  1915 -------RLRVISNRLESIMSALSGGFIELDSRTEGSYIKFNPKVENG--IMQSISEKDALLFFD 1970

  Fly  1248 --MEETSDSWELAHFRLPLSGALKSHHHLNNNSHGYVHSNSSSNLSGILQ 1295
              :.....|..|.|.|......|:    :..|......||..:.:..:||
Yeast  1971 HVITRIESSVALLHLRQQRCSGLE----ICRNDKTSARSNIFNVVDELLQ 2016

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	93/565 (16%)
		ANF_receptor	108..473	CDD:279440	81/504 (16%)
		PK_GC-A_B	589..883	CDD:270944	72/390 (18%)
		Pkinase_Tyr	613..877	CDD:285015	64/360 (18%)
		HNOBA	<893..938	CDD:285003	8/63 (13%)
		CYCc	917..1108	CDD:214485	49/227 (22%)
		Guanylate_cyc	944..1130	CDD:278633	51/230 (22%)
CYR1	NP_012529.3	Ad_cyc_g-alpha	368..418	CDD:369912
		RA_PHLPP_like	678..776	CDD:340473	14/99 (14%)
		PLN00113	792..>1273	CDD:215061	93/543 (17%)
		leucine-rich repeat	796..817	CDD:275380	6/29 (21%)
		leucine-rich repeat	818..839	CDD:275380	7/20 (35%)
		leucine-rich repeat	840..864	CDD:275380	5/24 (21%)
		leucine-rich repeat	865..887	CDD:275380	4/21 (19%)
		leucine-rich repeat	888..910	CDD:275380	4/21 (19%)
		leucine-rich repeat	911..933	CDD:275380	1/21 (5%)
		leucine-rich repeat	934..956	CDD:275380	3/21 (14%)
		leucine-rich repeat	957..978	CDD:275380	2/20 (10%)
		leucine-rich repeat	979..1018	CDD:275380	12/45 (27%)
		leucine-rich repeat	1019..1041	CDD:275380	5/23 (22%)
		leucine-rich repeat	1042..1065	CDD:275380	2/22 (9%)
		leucine-rich repeat	1066..1088	CDD:275380	2/21 (10%)
		leucine-rich repeat	1089..1111	CDD:275380	2/21 (10%)
		leucine-rich repeat	1167..1187	CDD:275380	5/29 (17%)
		leucine-rich repeat	1191..1211	CDD:275380	4/41 (10%)
		leucine-rich repeat	1236..1258	CDD:275380	5/27 (19%)
		leucine-rich repeat	1259..1287	CDD:275380	1/27 (4%)
		PP2C	1374..1617	CDD:395385	48/258 (19%)
		CYCc	1613..1825	CDD:214485	55/263 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900