DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and Gucy2d

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_077356.1	Gene:	Gucy2d / 79222	RGDID:	620438	Length:	1108	Species:	Rattus norvegicus

Alignment Length:	1240	Identity:	386/1240 - (31%)
Similarity:	576/1240 - (46%)	Gaps:	242/1240 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 AAWFYDAESVGGVASIGVGSDEHSFKTPETKNSHKSQSTELVQHFPSLPMPDHRRLGARRQLVFV 89
            :||...|   ||....|       |..|..: |..|.|..|....|.||           .|:.:
  Rat     2 SAWLLPA---GGFPGAG-------FCIPAWQ-SRSSLSRVLRWPGPGLP-----------GLLLL 44

  Fly    90 ALLPSVESDN-----------KNDCIMPKVLPVL--ELAIRHVQR-MGFVGGSHFDIQLI----- 135
            .||||..:.:           ..|.|..:..|.|  .||...:.| :...||..|::.|:
  Rat    45 LLLPSPSAFSAVFKVGVLGPWACDPIFARARPDLAARLATDRLNRDLALDGGPWFEVTLLPEPCL 109

  Fly   136 ---------SRDTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGG 191
                     |..|..|...||            ||.....|.|.    :::.|.|..||....|
  Rat   110 TPGSLGAVSSALTRVSGLVGP------------VNPAACRPAEL----LAQEAGVALVPWGCPG- 157

  Fly   192 NAKEFNKKSESYSTLTRLKGA---QVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLC 253
                           ||..|.   .|....:.:..:|.:|.|.|.|||...::..|:........
  Rat   158 ---------------TRAAGTTAPAVTPAADALYVLLKAFRWARVALITAPQDLWVEAGRALSTA 207

  Fly   254 LAAIHDTIEEHSVYQLGFDTSTWTK---ADIT------RMLKNVAMQSRIVIMCADP-----QSI 304
            |.|            .|...:..|.   :|::      |.::: ..:.|:|||....     :..
  Rat   208 LRA------------RGLPVALVTSMVPSDLSGAREALRRIRD-GPRVRVVIMVMHSVLLGGEEQ 259

  Fly   305 RQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQP 369
            |.::..||||.:.| |..||:.   |..:.|..| |..:.....:|:.:.::|:.|:||:|.:.|
  Rat   260 RYLLEAAEELGLTD-GSLVFLP---FDTLHYALS-PGPEALAAFVNSSKLRRAHDAVLTLTRRCP 319

  Fly   370 ---NDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRP 431
               :..:..|.:.|.:.:..:      .|.:.:|....:.:|.|.|.|..           :||.
  Rat   320 PGGSVQDSLRRAQEHQELPLD------LDLKQVSPLFGTIYDAVFLLAGG-----------VTRA 367

  Fly   432 --------INGTDMVRRMWNR---SFTGITGN--------VTIDANGDRLSAYSLLDMNPTTGRF 477
                    ::|..:.|:|...   .|.||.|.        :..||.|:||....|||  |..|..
  Rat   368 RAAVGGGWVSGASVARQMREAQVFGFCGILGRTEEPSFVLLDTDAAGERLFTTHLLD--PVLGSL 430

  Fly   478 EIVAHFLHNRLEFEANKEIHWAGDREEAPPDRPICGYD-GALCPDNSLPGYAILSIVLGTMVVVM 541
            .            .|...:|:........|| |.|.:| ..:|.....||...:..:| .:||.:
  Rat   431 R------------SAGTPVHFPRGAPAPGPD-PSCWFDPDVICNGGVEPGLVFVGFLL-VIVVGL 481

  Fly   542 AVCFFFGY-RHYIAEAEINSMSWKV--SLEDVMF----RDAAERGLRGSFHSLVKQSSQLTLMSE 599
            ...|...| ||.:...::.|...|:  :||||.|    ..::.:..:||      :||..|..:.
  Rat   482 TGAFLAHYLRHRLLHMQMVSGPNKIILTLEDVTFLHPQGGSSRKVAQGS------RSSLATRSTS 540

  Fly   600 DMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACL- 663
            |:.|:....|....:|::....|.:|....::...:...:.| ...::::|:|:::..:.|..|
  Rat   541 DIRSVPSQPQESTNIGLYEGDWVWLKKFPGEHHMAIRPATKM-AFSKLRELRHENVALYLGLFLA 604

  Fly   664 ---DQRRS------FLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHG 719
               |...:      .:::|:|.:|||.|:|.....:|||||:.||:.|:::||::||...: :||
  Rat   605 GTADSPATPGEGILAVVSEHCARGSLHDLLAQRDIKLDWMFKSSLLLDLIKGMRYLHHRGV-AHG 668

  Fly   720 NLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLR---VEHNR 781
            .|||.|||||.|||||:||.|...|...:..|......       ...|||||||||   :|.
  Rat   669 RLKSRNCVVDGRFVLKVTDHGHGRLLEAQRVLPEPPSA-------EDQLWTAPELLRDPALER-- 724

  Fly   782 PPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNG 846
              .||..|||::.|||:.|:..|..|:.:    .|.:|:|:|:.|:  :|..:.:|    |....
  Rat   725 --RGTLAGDVFSLGIIMQEVVCRSTPYAM----LELTPEEVIQRVR--SPPPLCRP----LVSMD 777

  Fly   847 DTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEER 911
            ....:...::.:||||.|..||..:....:.:..||..:| ||:|::|:.:|.|::|||:|:.||
  Rat   778 QAPMECIQLMAQCWAEHPELRPSMDLTFDLFKGINKGRKT-NIIDSMLRMLEQYSSNLEDLIRER 841

  Fly   912 TQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQ 976
            |::..:||:|.::||.|:||.|||..|..|..|..|.|::||:|||||||||.|||.|.|::||.
  Rat   842 TEELEQEKQKTDRLLTQMLPPSVAEALKMGTSVEPEYFEEVTLYFSDIVGFTTISAMSEPIEVVD 906

  Fly   977 FLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHR 1041
            .||||||.||:|:.:.||||||||||||||.||||.|||.:||.|||.::|.:|.||.:||:.|.
  Rat   907 LLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIANMSLDILSAVGSFRMRHM 971

  Fly  1042 PEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETT---KEALDE 1103
            ||..:::|||||:|.||||||||.|||||||||||||||||||.|...:||::.:|   ..|||:
  Rat   972 PEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLPYRIHVNMSTVRILRALDQ 1036

  Fly  1104 FGTFVTTRRGFVPMKGKGEMLTYWLEGEV------PRPNSL--------ISPSKLMLTRRSSLKQ 1154
              .|....||...:||||...||||.|.|      |:|..|        ||..::...||..|::
  Rat  1037 --GFQMECRGRTELKGKGVEDTYWLVGRVGFNKPIPKPPDLQPGASNHGISLQEIPPERRKKLEK 1099

  Fly  1155 PQRSQ 1159
            .:..|
  Rat  1100 ARPGQ 1104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	99/476 (21%)
		ANF_receptor	108..473	CDD:279440	90/420 (21%)
		PK_GC-A_B	589..883	CDD:270944	91/306 (30%)
		Pkinase_Tyr	613..877	CDD:285015	84/276 (30%)
		HNOBA	<893..938	CDD:285003	21/44 (48%)
		CYCc	917..1108	CDD:214485	118/193 (61%)
		Guanylate_cyc	944..1130	CDD:278633	116/188 (62%)
Gucy2d	NP_077356.1	PBP1_sensory_GC_DEF-like	58..434	CDD:380594	94/456 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	520..552		8/37 (22%)
		PK_GC-2D	540..814	CDD:270945	88/296 (30%)
		HNOBA	<823..868	CDD:400168	21/44 (48%)
		CYCc	848..1039	CDD:214485	118/192 (61%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1069..1108		9/36 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820