DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and Gucy2g

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001074545.1	Gene:	Gucy2g / 73707	MGIID:	106025	Length:	1100	Species:	Mus musculus

Alignment Length:	1075	Identity:	362/1075 - (33%)
Similarity:	565/1075 - (52%)	Gaps:	107/1075 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   119 VQRMGF-------------VGGSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNAVFGLPCEY 170
            |||:|.             ||..:...:....::.||:|.. :..|....|...::|:||..|..
Mouse    62 VQRLGAGLQTVVDKLNSEPVGLGNVSWEFTYTNSTCSAKES-LAVFIDQVQKEHISALFGPACPE 125

  Fly   171 VLAPISRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTAL 235
            ....|...|..|.:|:....|............:.:|.:...|  .:..|:|..|....|....
Mouse   126 AAEVIGLLASEWNIPLFDFVGQMAALKDHFWCDTCVTLVPPKQ--EISAVLRESLRYLGWEHIG- 187

  Fly   236 IYQNENAKVKGNSVCFLCLAAIHDTIEEH--SVYQLGFDTSTWTKADITRM-LKNVAMQSRIVIM 297
            ::...:|......|..: ..|:.|.::.|  ....:.:::|:   :|:.:. |:|::..:|::|:
Mouse   188 VFGGSSADSSWEQVDEM-WGAVEDGLQFHFNITASMRYNSSS---SDLLQEGLRNMSYVARVIIL 248

  Fly   298 CADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAML 362
            ....:..|:|:..|.:|. :|:||:|||      .:|.|....|.:....| ...|..|.|.::.
Mouse   249 ICSSEDARRILQAAVDLG-LDTGEFVFI------LLQQLEDSFWKEVLTKD-KVIRFPKVYESVF 305

  Fly   363 TVTPKQ-----PNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIR 422
            .:.|..     .:|....:||.|::   ...:..:.:..:.:|.:.....|.:||||..:.|..:
Mouse   306 LIAPSAYGGGIGDDGFRKQVSQELR---RPPFQSSITSEDQVSPYSAYLHDALLLYAQTVEEMRK 367

  Fly   423 EDPTMLTRPINGTDMVR--RMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLH 485
            .:....    :|..::.  |....:..||||.|.:|:.|.|...||:..:. .:|...:...|||
Mouse   368 AEKDFR----DGRQLISTLRAGQVTLQGITGPVLLDSQGKRHVDYSVYALQ-ESGNRSLFLPFLH 427

  Fly   486 NRLEFEANKEI--HWAGDREEA------PPDRPICGYDGALCPDNSLPGYAILSIVLG------T 536
                :::.:::  .|..|...:      |..:|.||:...||.... |..|.:::.:.      |
Mouse   428 ----YDSFQKVIRPWRNDSNTSWPHGSLPEYKPGCGFHNDLCKTKP-PTVAGMTVTVTAVIPTVT 487

  Fly   537 MVVVMAVCFFFGYRHYIAEAEINSMS----WKVSLEDVMFRDAAERGLRG--------SFHSLVK 589
            .:|:.:.....|...:....::.|..    |::..:.:......:...||        |..|.||
Mouse   488 FLVLASAAAITGLMLWRLRGKVQSHPGDTWWQIRYDSITLLPQHKLSHRGTPVSRRNVSDTSTVK 552

  Fly   590 QSSQLTLMSEDMVSINGDRQIFI-PVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHD 653
            .|:.    ...:|..:.|.::|. |||:::.::||:..:..:....:...::..|:..|.:|:|:
Mouse   553 ASAD----CGSLVKRHQDEELFFAPVGLYQGNQVALCYIGDEAEAWVKKPTVRREVCLMCELKHE 613

  Fly   654 HLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSH 718
            ::|.|:|.|.:.....::|:||.||||||::.|...::||:|:||..:|||.|:.|||.|.:|||
Mouse   614 NIVPFFGVCTEPPNICIVTQYCKKGSLQDVMRNSDHEIDWIFKLSFAYDIVNGLLFLHGSPLRSH 678

  Fly   719 GNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAY-WSKLLWTAPELLRVEHNRP 782
            ||||.|||:|||...||::.|||     ..|...|...:.|..|. .|:|.||||||||:..: |
Mouse   679 GNLKPSNCLVDSHMQLKLSGFGL-----WEFKHGSTWRSYNQEATDHSELYWTAPELLRLRES-P 737

  Fly   783 PEGTQKGDVYAFGIIVHEITTRQ--GPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPE-LEP 844
            ..||.:||||:|.|::.::..:|  |||.    ..|.:|:|||..:|  :| |...|.||. ||.
Mouse   738 CSGTPQGDVYSFAILLRDLIHQQAHGPFE----DLEAAPEEIISRIK--DP-RAPVPLRPSLLED 795

  Fly   845 NGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVE 909
            .||.:  |..::|.||.|.|..||.|.::|..:|..:..... :|:|:::.::|.|||:|||:||
Mouse   796 KGDGR--IVALVRECWDESPELRPIFPSIKKTLREASPRGHV-SILDSMMGKLETYANHLEEVVE 857

  Fly   910 ERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQV 974
            |||::...||:|.||||..:||..|..|||:|:.|..|.|:.|||:||||||||.:.:.|:|:||
Mouse   858 ERTRELVAEKRKVEKLLSTMLPSFVGEQLIAGKSVEPEHFESVTIFFSDIVGFTKLCSLSSPLQV 922

  Fly   975 VQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIH 1039
            |:.|||||:.||..:::.||||||||||||||.||||||||.|||.|||.:||.||....:|:|.
Mouse   923 VKLLNDLYSLFDHTIQSHDVYKVETIGDAYMVASGLPIRNGAQHADEIATMALHLLSVTTHFQIG 987

  Fly  1040 HRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEF 1104
            |.||:|||||||||||..||||||:.||||||||||||.||||||:...|:||:|::|..||...
Mouse   988 HMPEERLKLRIGLHTGPVVAGVVGITMPRYCLFGDTVNMASRMESSSLPLRIHVSQSTAGALLAA 1052

  Fly  1105 GTFVTTRRGFVPMKGKGEMLTYWLEGE----VPRP 1135
            |.:...:||.:.:|||||..|:||:|:    ||.|
Mouse  1053 GGYHLQKRGTISVKGKGEQTTFWLKGKDGFPVPLP 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	82/403 (20%)
		ANF_receptor	108..473	CDD:279440	78/376 (21%)
		PK_GC-A_B	589..883	CDD:270944	112/298 (38%)
		Pkinase_Tyr	613..877	CDD:285015	106/267 (40%)
		HNOBA	<893..938	CDD:285003	22/44 (50%)
		CYCc	917..1108	CDD:214485	120/190 (63%)
		Guanylate_cyc	944..1130	CDD:278633	116/185 (63%)
Gucy2g	NP_001074545.1	PBP1_GC_G-like	47..436	CDD:380595	82/401 (20%)
		PK_GC	555..829	CDD:270894	110/292 (38%)
		CYCc	865..1055	CDD:214485	120/189 (63%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	1	1.100	-	-	O	PTHR11920
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.820