Protein Alignment CG31183 and gucy2ca

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: XP_073799927.1
• Gene: gucy2ca / 572052
• ZFINID: ZDB-GENE-091118-67
• Length: 1071
• Species: Danio rerio
• Alignment Length: 1255
• Identity: 384/1255 - (30%)
• Similarity: 579/1255 - (46%)
• Gaps: 302/1255 - (24%)

  Fly     8 LSLLLILCLLQAHLFPSAAWFYDAESVGGVASIGVGS--------------DEHS---------- 48
            :.:|.:||.         .|.    |:.||:...|.|              ||:|
Zfish     1 MKMLALLCF---------CWV----SLLGVSGFNVLSCRNSSVTLNVVLLEDENSPWSLKFVKDV 52

  Fly    49 FKTPETKNSHKSQSTELVQH----FPSLPMPDHRRLGARRQLV-FVALLPSVESDNKNDCIMPKV 108
            .:|.....::|:.:..|..|    |.......:||.|...... .|.:|.|:.::::..|:|
Zfish    53 VETAVEDQNNKNHAEGLDFHIKVLFSGFNTTHYRRRGCGSSTCEAVEILKSLHNNSELGCVM--- 114

  Fly   109 LPVLELAIRHVQRMGFVGGS--HFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNA-VFGLPCEY 170
                            :|.|  :...||:.::         :|   :....|.::| .|||.|:|
Zfish   115 ----------------LGPSCTYATFQLVDQE---------VG---LTLTIPIISAGSFGLSCDY 151

  Fly   171 ------VLAPISRYAD----VWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAIL 225
                  :|.|..:.|:    .|                    ::::..||.|
Zfish   152 KQKLTRLLPPARKIAEFFFHFW--------------------HTSVKNLKPA------------- 183

  Fly   226 NSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTW-TKADITRMLKNVA 289
                | :||.:|:.:|.    ...||..:.|:.   ...:::......... ::::::..||...
Zfish   184 ----W-KTAYVYKKDNY----TEECFWYINALE---APSALFSSNISREMLRSESELSTALKRKD 236

  Fly   290 MQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERA 354
            ..|.|::||..|..|    .|.::.|.:.| :.|||.|:|:              |:....||.:
Zfish   237 RHSNIIVMCGTPDDI----YTIKKNNTVPS-QVVFILIDLY--------------NEGYRTNESS 282

  Fly   355 QKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNE 419
            ......:|.:|  ..:...|:  ||.:..      |.|.:.|:    :|..:.|.|:|:.||:..
Zfish   283 PAHMRNVLVLT--MHSFRNYS--SNSVWR------NNTTALND----YVVGYHDAVVLFGNAMRN 333

  Fly   420 SIRE-----------DPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMN-- 471
            :::.           ||     |..         |.||.||.|...:|::|||       |:|
Zfish   334 NLQRIKQQQGLSDNIDP-----PFR---------NMSFYGIGGYYKLDSSGDR-------DLNLS 377

  Fly   472 --PTTGRFEIVAHF----LHNRLEF-EANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAI 529
              .|||.::....|    ..||.:. :::.::.|  ||.:.|.|:           ...:....|
Zfish   378 VVYTTGSYKYRTLFSFDTSQNRTKVKDSSPDLPW--DRSQLPRDK-----------HTGMEIQEI 429

  Fly   530 LSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWK-VSLEDVMFRDAAERGLRGSFHSLVKQSSQ 593
            :.||||..||:..|..|..||.. .....:...|. :|...:...|..||    ::.||.
Zfish   430 MMIVLGLSVVLATVIAFILYRQN-RRVRFDQKKWSHISSSLITPLDDKER----NYISLT----- 484

  Fly   594 LTLMSEDMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKF 658
               :.||.   .||....|..|.:.|..|.:|  |:.|..|..|....:||..:..:.:.:|.||
Zfish   485 ---IDEDK---KGDNSSLIRKGRYDKKPVILK--ELRNTDGNFTDDQRIELNALLRIDYYNLTKF 541

  Fly   659 YGACLDQRRSFLLTEYCPKGSLQDILENE------QFQLDWMFRLSLMHDIVRGMQFLHSSDIRS 717
            ||........|.:.|:|.:|||:.:|:::      .| :|..||:|:|:||.:||.:||||::..
Zfish   542 YGTVRFDCGVFGVFEFCERGSLRYVLDDKISYPDASF-MDLEFRISVMYDIAKGMSYLHSSNVGV 605

  Fly   718 HGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRP 782
            ||.|||:|||||:|.|:||||||                 ||:.....|.||||||.:||
Zfish   606 HGRLKSTNCVVDNRMVVKITDFG-----------------CNTILSPGKDLWTAPEHMRV----- 648

  Fly   783 PEG-TQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPEL--EP 844
             || :||||||:|.||..||..|:.||:...|:.......:::..:|.|      .|||:|  |.
Zfish   649 -EGISQKGDVYSFAIISQEIILRKSPFHTSCCSDMAEKLYLVQYPRGPN------VFRPDLSFEG 706

  Fly   845 NGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRF--NKDNE-TGNIVDNLLKRMELYANNLEE 906
            .|:|:|::..:|:.||.|||.:||||..::..:.:.  |..|: ..:.:|||::|:::|:.|||.
Zfish   707 VGETEAELFVLIKSCWEEDPEKRPDFKRIEGALGKIFSNLHNQANASYMDNLIRRLQMYSRNLEH 771

  Fly   907 LVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTP 971
            ||||||..|..|:.:.::|.:.|||..|...|.....|..|.:|:||||||||||||.|...|||
Zfish   772 LVEERTALYKAERDRADQLNFMLLPGPVVRSLKETGRVEPELYDEVTIYFSDIVGFTTICHHSTP 836

  Fly   972 MQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNF 1036
            |:||..|||:|..||||:::.||||||||||||||.||||..|||:||.:|..:||.:||.:..|
Zfish   837 MEVVDMLNDIYKNFDSILDHHDVYKVETIGDAYMVASGLPRCNGNRHAVDICLMALDILEFMGTF 901

  Fly  1037 RIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEAL 1101
            ::.|.|...|.:|||:|:|.|.|||||.||||||||||||||||||||.|..|:||:||:|.:.|
Zfish   902 QLRHLPGIPLWIRIGIHSGPCAAGVVGNKMPRYCLFGDTVNTASRMESTGLPLRIHVSESTIKIL 966

  Fly  1102 DEFG-TFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLISP--------------SKLMLT---- 1147
            .... .|...|||...:||||:.:||||.|...:..||.:|              .:::.|
Zfish   967 QRTDCEFECERRGETFLKGKGKEMTYWLTGVTGQKYSLPTPPTVENFQRLQQDLAERIVSTLNKR 1031

  Fly  1148 ---RRSSLKQPQRSQSHNLH 1164
               ||.:|...||....::|
Zfish  1032 GNERRKTLSTRQRRTHTHIH 1051

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596	86/440 (20%)
		PK_GC-A_B	589..883	CDD:270944	108/304 (36%)
		HNOBA	<890..938	CDD:462234	21/47 (45%)
		CYCc	917..1108	CDD:214485	108/191 (57%)
gucy2ca	XP_073799927.1	None