DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and gucy2ca

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_009297342.1	Gene:	gucy2ca / 572052	ZFINID:	ZDB-GENE-091118-67	Length:	1025	Species:	Danio rerio

Alignment Length:	1245	Identity:	371/1245 - (29%)
Similarity:	554/1245 - (44%)	Gaps:	328/1245 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSLLLILCLLQAHLFPSAAWFYDAESVGGVASIGVGS--------------DEHS---------- 48
            :.:|.:||.         .|.    |:.||:...|.|              ||:|
Zfish     1 MKMLALLCF---------CWV----SLLGVSGFNVLSCRNSSVTLNVVLLEDENSPWSLKFVKDV 52

  Fly    49 FKTPETKNSHKSQSTELVQH----FPSLPMPDHRRLGARRQLV-FVALLPSVESDNKNDCIMPKV 108
            .:|.....::|:.:..|..|    |.......:||.|...... .|.:|.|:.::::..|:|
Zfish    53 VETAVEDQNNKNHAEGLDFHIKVLFSGFNTTHYRRRGCGSSTCEAVEILKSLHNNSELGCVM--- 114

  Fly   109 LPVLELAIRHVQRMGFVGGS--HFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNA-VFGLPCEY 170
                            :|.|  :...||:.::         :|   :....|.::| .|||.|:|
Zfish   115 ----------------LGPSCTYATFQLVDQE---------VG---LTLTIPIISAGSFGLSCDY 151

  Fly   171 ------VLAPISRYAD----VWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAIL 225
                  :|.|..:.|:    .|                    ::::..||.|
Zfish   152 KQKLTRLLPPARKIAEFFFHFW--------------------HTSVKNLKPA------------- 183

  Fly   226 NSFNWTRTALIYQNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTW-TKADITRMLKNVA 289
                | :||.:|:.:|.    ...||..:.|:.   ...:::......... ::::::..||...
Zfish   184 ----W-KTAYVYKKDNY----TEECFWYINALE---APSALFSSNISREMLRSESELSTALKRKD 236

  Fly   290 MQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERA 354
            ..|.|::||..|..|    .|.::.|.:.| :.|||.|:|
Zfish   237 RHSNIIVMCGTPDDI----YTIKKNNTVPS-QVVFILIDL------------------------- 271

  Fly   355 QKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNE 419
                                              ||..:..||...|.:.:..  ||...:..|.
Zfish   272 ----------------------------------YNEGYRTNESSPAHMRNVL--VLTMHSFRNY 300

  Fly   420 SIREDPTMLTRPINGTDMVRRMW-NRSFTGITGNVTIDANGDRLSAYSLLDMN----PTTGRFEI 479
            |...                 :| |.:...|.|...:|::|||       |:|    .|||.::.
Zfish   301 SSNS-----------------VWRNNTTVSIGGYYKLDSSGDR-------DLNLSVVYTTGSYKY 341

  Fly   480 VAHF----LHNRLEF-EANKEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVV 539
            ...|    ..||.:. :::.::.|  ||.:.|.|:           ...:....|:.||||..||
Zfish   342 RTLFSFDTSQNRTKVKDSSPDLPW--DRSQLPRDK-----------HTGMEIQEIMMIVLGLSVV 393

  Fly   540 VMAVCFFFGYRHYIAEAEINSMSWK-VSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMVS 603
            :..|..|..||.. .....:...|. :|...:...|..||    ::.||.        :.||.
Zfish   394 LATVIAFILYRQN-RRVRFDQKKWSHISSSLITPLDDKER----NYISLT--------IDEDK-- 443

  Fly   604 INGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRS 668
             .||....|..|.:.|..|.:|  |:.|..|..|....:||..:..:.:.:|.||||........
Zfish   444 -KGDNSSLIRKGRYDKKPVILK--ELRNTDGNFTDDQRIELNALLRIDYYNLTKFYGTVRFDCGV 505

  Fly   669 FLLTEYCPKGSLQDILENE------QFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCV 727
            |.:.|:|.:|||:.:|:::      .| :|..||:|:|:||.:||.:||||::..||.|||:|||
Zfish   506 FGVFEFCERGSLRYVLDDKISYPDASF-MDLEFRISVMYDIAKGMSYLHSSNVGVHGRLKSTNCV 569

  Fly   728 VDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEG-TQKGDV 791
            ||:|.|:||||||                 ||:.....|.||||||.:||      || :|||||
Zfish   570 VDNRMVVKITDFG-----------------CNTILSPGKDLWTAPEHMRV------EGISQKGDV 611

  Fly   792 YAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPEL--EPNGDTKADING 854
            |:|.||..||..|:.||:...|:.......:::..:|.|      .|||:|  |..|:|:|::..
Zfish   612 YSFAIISQEIILRKSPFHTSCCSDMAEKLYLVQYPRGPN------VFRPDLSFEGVGETEAELFV 670

  Fly   855 IIRRCWAEDPAERPDFNTLKSMIRRF--NKDNE-TGNIVDNLLKRMELYANNLEELVEERTQDYH 916
            :|:.||.|||.:||||..::..:.:.  |..|: ..:.:|||::|:::|:.|||.||||||..|.
Zfish   671 LIKSCWEEDPEKRPDFKRIEGALGKIFSNLHNQANASYMDNLIRRLQMYSRNLEHLVEERTALYK 735

  Fly   917 EEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDL 981
            .|:.:.::|.:.|||..|...|.....|..|.:|:||||||||||||.|...||||:||..|||:
Zfish   736 AERDRADQLNFMLLPGPVVRSLKETGRVEPELYDEVTIYFSDIVGFTTICHHSTPMEVVDMLNDI 800

  Fly   982 YTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRL 1046
            |..||||:::.||||||||||||||.||||..|||:||.:|..:||.:||.:..|::.|.|...|
Zfish   801 YKNFDSILDHHDVYKVETIGDAYMVASGLPRCNGNRHAVDICLMALDILEFMGTFQLRHLPGIPL 865

  Fly  1047 KLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFG-TFVTT 1110
            .:|||:|:|.|.|||||.||||||||||||||||||||.|..|:||:||:|.:.|.... .|...
Zfish   866 WIRIGIHSGPCAAGVVGNKMPRYCLFGDTVNTASRMESTGLPLRIHVSESTIKILQRTDCEFECE 930

  Fly  1111 RRGFVPMKGKGEMLTYWLEGEVPRPNSLISP--------------SKLMLT-------RRSSLKQ 1154
            |||...:||||:.:||||.|...:..||.:|              .:::.|       ||.:|..
Zfish   931 RRGETFLKGKGKEMTYWLTGVTGQKYSLPTPPTVENFQRLQQDLAERIVSTLNKRGNERRKTLST 995

  Fly  1155 PQRSQSHNLH 1164
            .||....::|
Zfish   996 RQRRTHTHIH 1005

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	73/433 (17%)
		ANF_receptor	108..473	CDD:279440	62/383 (16%)
		PK_GC-A_B	589..883	CDD:270944	108/304 (36%)
		Pkinase_Tyr	613..877	CDD:285015	102/272 (38%)
		HNOBA	<893..938	CDD:285003	19/44 (43%)
		CYCc	917..1108	CDD:214485	108/191 (57%)
		Guanylate_cyc	944..1130	CDD:278633	113/186 (61%)
gucy2ca	XP_009297342.1	Periplasmic_Binding_Protein_Type_1	31..365	CDD:299141	84/499 (17%)
		PKc_like	428..698	CDD:304357	112/316 (35%)
		Pkinase_Tyr	451..689	CDD:285015	103/269 (38%)
		CYCc	736..929	CDD:214485	109/192 (57%)
		Guanylate_cyc	763..950	CDD:278633	113/186 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920