DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and adcy3a

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_009290286.1	Gene:	adcy3a / 571825	ZFINID:	ZDB-GENE-111027-6	Length:	1119	Species:	Danio rerio

Alignment Length:	287	Identity:	88/287 - (30%)
Similarity:	152/287 - (52%)	Gaps:	46/287 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   900 YANNLEELVEERTQ-----DYHEEKKKC-------EKLLYQLLPQSVAAQLISG----QPVVAET 948
            ::.::|:|.  ||.     :.||:|:|.       |.|:..:||:.||...:..    :.:.:::
Zfish   831 FSRHVEKLA--RTLFLWKIEVHEQKEKVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELYSQS 893

  Fly   949 FDQVTIYFSDIVGF----TAISAESTPMQVVQFLNDLYTCFDSIVENFD---VYKVETIGDAYMV 1006
            :|::.:.|:.|..|    |..|..:..::.::|||::.:.|||:::...   :.|::|||..||.
Zfish   894 YDEIGVMFASIPNFSDFYTEESINNGGIECLRFLNEIISDFDSLLDEPQFRCITKIKTIGSTYMA 958

  Fly  1007 VSGLPIRNGN-----------------QHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHT 1054
            .||:...|..                 ||..::|..|||:...:.|  |:::..:...|||||:.
Zfish   959 ASGVTSDNNTNGYACMKKEEISDRERWQHLADLADFALAMKVTLMN--INYQSFNNFMLRIGLNK 1021

  Fly  1055 GACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKG 1119
            ||.:|||:|.:.|.:.::|:|||.||||||.|....|.:.|.....|.::| |...|||.:.:||
Zfish  1022 GAVLAGVIGARKPHFDIWGNTVNVASRMESTGVMGNIQVVEDCYCILKDYG-FRFVRRGPIFVKG 1085

  Fly  1120 KGEMLTYWLEGEVPRPNSLISPSKLML 1146
            |||:|||:|:|. .:..|.|:.|.:.|
Zfish  1086 KGELLTYFLKGR-EKQGSFINGSFVTL 1111

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944
		Pkinase_Tyr	613..877	CDD:285015
		HNOBA	<893..938	CDD:285003	14/49 (29%)
		CYCc	917..1108	CDD:214485	65/225 (29%)
		Guanylate_cyc	944..1130	CDD:278633	69/209 (33%)
adcy3a	XP_009290286.1	AC_N	<37..304	CDD:292831
		CYCc	273..468	CDD:214485
		Guanylate_cyc	310..492	CDD:278633
		CYCc	858..1075	CDD:214485	63/219 (29%)
		Guanylate_cyc	889..1096	CDD:278633	69/209 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900