DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and adcy6a

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_017209219.1	Gene:	adcy6a / 570652	ZFINID:	ZDB-GENE-060221-1	Length:	1203	Species:	Danio rerio

Alignment Length:	1202	Identity:	244/1202 - (20%)
Similarity:	427/1202 - (35%)	Gaps:	368/1202 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 DCIMPKVLPV---LELAIRHV-QRMGFVGGSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNA 162
            |.:...||.|   |.||:..| .|.||           .:|......|..||...|.       .
Zfish   204 DVVYASVLSVAMALFLALMVVCNRNGF-----------HQDYMWMVSYLVIGVLIIV-------Q 250

  Fly   163 VFGLPCEYVLAPISRYADVWQ----VPVLTTGGNAKEFNKKSESYSTL-TRLKGAQVNNLGNVVR 222
            |||:   .::||.|....:|.    :.::               |:.| .|::.|.::  |.|:.
Zfish   251 VFGV---LMVAPRSASEGIWWSVFFIYII---------------YTLLPVRMRAAVLS--GGVLS 295

  Fly   223 AILNSFNWTRTALIYQNEN---AKVKGNSVCFLCLAAI----H--DTIEEHSVYQLGFDTSTWTK 278
            ||.....|.    |.|::.   .::..|.:.|||...|    |  ..:.:...:|   :|..:.:
Zfish   296 AIHLLTTWR----INQDDEFLWKQLSANVLIFLCTNIIGICTHYPAEVSQRQAFQ---ETRGYIQ 353

  Fly   279 ADITRMLKNVAMQSRIVIMCADPQSIRQIM---LTAEELNMI---------DSGEYVFINIELFS 331
            |.:....:|  .|...:::...|:.:...|   :.|::.:|:         |:...:|.:||.|:
Zfish   354 ARLHLQREN--QQQERLLLSVLPRHVAMEMKADINAKKEDMMFHKIYIQKHDNVSILFADIEGFT 416

  Fly   332 RVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDN 396
            .   |.||....:....||.         :.....|..::|...|:.     |..:.|.......
Zfish   417 S---LASQCTAQELVMTLNE---------LFARFDKLASENHCLRIK-----ILGDCYYCVSGLP 464

  Fly   397 EPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRM-WNRSFTGITGNVTIDANGD 460
            ||.:.           :|:...|.             |.||:..: ..|..||:..|:.:..:..
Zfish   465 EPRAD-----------HAHCCVEM-------------GVDMIEAISLVREVTGVNVNMRVGIHSG 505

  Fly   461 RLSAYSL-------------------LDMNPTTGRFEIVAHFLHNRLEFEANKEIHWAGDREEAP 506
            |:....|                   ::.....||..|....|.           :..||.|..|
Zfish   506 RVHCGVLGLRKWQFDVWSNDVTLANHMEAGGKAGRIHITKATLQ-----------YLNGDYEVEP 559

  Fly   507 PDRPICGYDG---ALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLE 568
                  |:.|   |...:||:..:    :|||        |                 |.|...|
Zfish   560 ------GFGGERNAYLKENSIETF----LVLG--------C-----------------SQKRKDE 589

  Fly   569 DVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMVSINGDRQIFIPVGM-------FRKSKVAIKP 626
            ..|.. ..:|....|..:||.:     .:.:...|...|.::|..:|:       .|.::.|:.|
Zfish   590 KAMMA-KMQRTRTNSNEALVPR-----WVPDRSFSRTKDSKVFRQMGIDETSSKDNRGAQEALNP 648

  Fly   627 VEVDNVQGLLTRSLMLELKRMKDLQHDHLVKF------------YGACLDQR------------- 666
              .|.|...|.|:  ::.:.:..|:.||:.||            |...:|.|
Zfish   649 --EDEVDEFLGRA--IDARSIDQLRKDHVKKFLLTFQTSSLEKKYAKKVDDRFGGYVACTLLVFC 709

  Fly   667 -RSFLLTEYCPKG--------SLQDILENEQFQLDWMFRLSLMHDIVR----GMQFLHSSDIRSH 718
             .||:.....|..        |:..||.|..|       :..::..|:    .||.:....::|.
Zfish   710 FISFIQIVVFPHTLVMLGIYISIFIILANILF-------ICAIYSCVKLFPAAMQTVSKKIVQSR 767

  Fly   719 GNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAY---------WSKLLWT---- 770
            .|               .|..|:.|:.........:..:|::...         ||..:.|
Zfish   768 TN---------------STLVGVFTIILVFISAFVNMFSCDTQKLVDCVAKQLNWSSEMVTPCII 817

  Fly   771 -------APELLRVEHNRP----PEGTQKGDVYAFGIIVH--------EITTRQGPFYLGRCAYE 816
                   |..|....:|.|    ||      .:::.:::.        :|::      :|:.|..
Zfish   818 HNMSRSVADGLSICPNNTPSCPFPE------YFSYSVLLTLLACSVFLQISS------IGKLALM 870

  Fly   817 KSPQEIIELVKGYNPHRMQKPFRPE--LEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSM--- 876
            ...|....|:..:          ||  |..|.|.....|.::    ..:..:..:|||....
Zfish   871 LLIQLTFLLLVEW----------PEVALFDNADLFVTANALV----FNETLQWSNFNTTTEQCTF 921

  Fly   877 -IRRFNKDNETGNIVDNLLKRMELYANNLEELVE----------ERTQDYHEEKKKCEKLLYQLL 930
             :.:.:....|..|:...:..:.|:|..:|....          |..::..|.:....:||:.:|
Zfish   922 RVTKVSLKVMTPVILTVFVLALYLHAQQVESTARLDFLWKLQATEEKEEMEELQAYNRRLLHNIL 986

  Fly   931 PQSVAAQLISGQPVVAETFDQ----VTIYFSDIVGFT----AISAESTPMQVVQFLNDLYTCFDS 987
            |:.|||..::.:....|.:.|    |.:.|:.|..|:    .:.|.:..::.::.||::...||.
Zfish   987 PKDVAAHFLARERRNDELYYQSCECVAVMFASISNFSEFYVELEANNEGVECLRLLNEIIADFDE 1051

  Fly   988 IV--ENF-DVYKVETIGDAYMVVSGLP----IRNGNQHAREIARLALALLEAV-----HNFRIHH 1040
            |:  |.: .:.|::|||..||..|||.    .:.|..|...:|..|:.|.|.:     |:|
Zfish  1052 IISEEKYRQLEKIKTIGSTYMAASGLNDSTYDKEGRSHITALADYAMHLREQMKYINEHSF---- 1112

  Fly  1041 RPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFG 1105
               :..:::|||:.|..||||:|.:.|:|.::|:|||.||||:|.|...:|.::....:.|...|
Zfish  1113 ---NNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDLHQVLHSKG 1174

  Fly  1106 TFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNS 1137
             :....||.:.:||||||.||:| .:.| |||
Zfish  1175 -YQLECRGVIKVKGKGEMTTYFL-NDGP-PNS 1203

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	81/445 (18%)
		ANF_receptor	108..473	CDD:279440	76/414 (18%)
		PK_GC-A_B	589..883	CDD:270944	59/376 (16%)
		Pkinase_Tyr	613..877	CDD:285015	56/346 (16%)
		HNOBA	<893..938	CDD:285003	12/54 (22%)
		CYCc	917..1108	CDD:214485	62/210 (30%)
		Guanylate_cyc	944..1130	CDD:278633	65/205 (32%)
adcy6a	XP_017209219.1	AC_N	<97..395	CDD:318454	49/237 (21%)
		Guanylate_cyc	397..570	CDD:306677	39/230 (17%)
		DUF1053	609..696	CDD:310728	18/95 (19%)
		Guanylate_cyc	1004..1197	CDD:306677	64/201 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810