DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and adcy1b

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001161822.1	Gene:	adcy1b / 569499	ZFINID:	ZDB-GENE-100805-1	Length:	1114	Species:	Danio rerio

Alignment Length:	466	Identity:	121/466 - (25%)
Similarity:	200/466 - (42%)	Gaps:	113/466 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   857 RRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRME----LYANNLEELVEERTQDYHE 917
            :|.|....|     |||     .|...|.:|..|..|.:|.:    |.|.|   .:|||.: ..:
Zfish   186 QRLWRSLVA-----NTL-----LFTGVNVSGLFVRILTERAQRKAFLQARN---CIEERLR-MED 236

  Fly   918 EKKKCEKLLYQLLPQSVAAQLISG---------QPVVAETFDQVTIYFSDIVGFTAISAESTPMQ 973
            |.:|.|:||..|||::||.::...         ..:..:..|.|:|.|:||||.|:::::.|..:
Zfish   237 ENEKQERLLMSLLPRNVAMEMKEDFLKPPERIFHKIYIQRHDNVSILFADIVGSTSLASQCTAQE 301

  Fly   974 VVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRI 1038
            :|:.||:|:..||.:.......:::.:||.|..|||| .:....||.....:.|.:::.:.:  :
Zfish   302 LVKLLNELFGKFDELATENHCRRIKILGDCYYCVSGL-TQPKTDHAHCCVEMGLDMIDTITS--V 363

  Fly  1039 HHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDE 1103
            ....|..|.:|:|||||..:.||:||:..:|.::.:.|..|:.||:.|...|:||:.:|.|.|:
Zfish   364 AEATEVDLNMRVGLHTGRVLCGVLGLRKWQYDVWSNDVTLANMMEAGGLPGKVHITRSTLECLN- 427

  Fly  1104 FGTFVT------TRRGFVPMKGKGEMLTYWLEGEVPRPN----------SLISPSK--------- 1143
             |.:..      .|..|:.   |.::.|:::   || |:          |.|.|:|
Zfish   428 -GDYEVEPGNGRERHAFLL---KHDIETFFI---VP-PHRRKIFPGLILSDIKPAKKMKFKTVCY 484

  Fly  1144 ----LMLTRRSSLKQPQRSQSHNLHKQYSELVVASPPPQL---PPPAIALPPPPSPSKDSPNLRV 1201
                ||..|:....:...|...|........|:.|.|.:|   .|.|.:.|      :.||..||
Zfish   485 LLVQLMHCRKMFRAEIPFSNVMNCEDGDKRRVLRSAPEKLRNRTPTAASAP------QSSPGTRV 543

  Fly  1202 KRKISSSSPKLNGGGFDYHKTENHYLDTAAAAQRNCDI-YSSRSLRDMEETSDSWELAHFRLPLS 1265
            .|.|:..        .:..:||:   |||       |: |.:...||.|..
Zfish   544 NRYINRL--------IEARQTES---DTA-------DLNYLTLMYRDSERE-------------- 576

  Fly  1266 GALKSHHHLNN 1276
               :.:|.||:
Zfish   577 ---RRYHQLND 584

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	7/25 (28%)
		Pkinase_Tyr	613..877	CDD:285015	6/19 (32%)
		HNOBA	<893..938	CDD:285003	18/48 (38%)
		CYCc	917..1108	CDD:214485	61/199 (31%)
		Guanylate_cyc	944..1130	CDD:278633	55/191 (29%)
adcy1b	NP_001161822.1	AC_N	<128..270	CDD:292831	28/97 (29%)
		CYCc	236..431	CDD:214485	61/199 (31%)
		Guanylate_cyc	272..454	CDD:278633	55/189 (29%)
		DUF1053	498..585	CDD:283888	28/128 (22%)
		CYCc	806..1012	CDD:214485
		Guanylate_cyc	839..1035	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900