DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and gucy2cb

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_021329920.1	Gene:	gucy2cb / 568219	ZFINID:	ZDB-GENE-130531-31	Length:	1071	Species:	Danio rerio

Alignment Length:	1156	Identity:	358/1156 - (30%)
Similarity:	537/1156 - (46%)	Gaps:	237/1156 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 LVFVALLPSVESDNKNDCIMPKVLPVLELAIRHVQRMGFVGGSHFDIQ------LISRDTFCSSK 144
            |:.|.||    .|:.:...:..|.|.:..|:.....:.|..|.:..:.      :..:.|.|||.
Zfish    32 LINVVLL----DDDVSPWSINFVKPAVMRAVESDSEINFKDGVNLSVSFRGFQTIYYQKTGCSSS 92

  Fly   145 --YGPIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADV-----WQVPVLTTGGNAKEFNKKSES 202
              .|.....::.....|..|:.|..|.|.   ..:.||:     ..:|:::.|    .|....:.
Zfish    93 ACEGVEILNDLANAGEEGCALLGPTCTYA---TFQMADLEIGLNLNMPIISAG----SFGLSCDL 150

  Fly   203 YSTLTRLKGAQVNNLGNVVRAILNSF------------NWTRTALIYQNENAKVKGNSVCFLCLA 255
            ...||||...        .|.|.:.|            .| .||.:|:    |......||..:.
Zfish   151 KRDLTRLLPP--------ARKISSFFINFWKFHDPVKPKW-ETAYLYK----KPDNTEDCFWYIN 202

  Fly   256 AIHDTIEEHSVYQLGFDTSTW------TKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEEL 314
            |:       .|...||..|..      .|.|:|:.:.....:|.:.|:|..|..|..:.....:.
Zfish   203 AL-------EVSNGGFSPSLQEIEVIRNKEDLTKAMAKHNRESNLFILCGTPDDIMDLKNGTTDY 260

  Fly   315 NMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSN 379
            :    .|..|:.|:|::.:.|      ..:::|.:.|         :|.:|  .||    ||
Zfish   261 D----SEIAFLLIDLYNDIYY------KGQSNTFMRN---------VLVLT--MPN----TR--- 297

  Fly   380 EIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNR 444
                    ||....|.|..::.::.::.|.|||:...: .:|::..::..:.:....| ....|.
Zfish   298 --------KYTIDTSGNNTMNDYIAAYHDAVLLFGQVM-RNIQKSGSLDIQDMESVSM-NYFRNV 352

  Fly   445 SFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHF--LHNRLEF-EANKEIHWAGDREEAP 506
            |||||.|...:|.:|||...:||:..| ...::.|:..|  .:|:... :::....|   :...|
Zfish   353 SFTGIAGEYQLDQHGDRDLMFSLIYTN-NNNQYNILYQFNTSNNKTGLKDSSPSFIW---QSRLP 413

  Fly   507 PDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVM---AVCFFFGYRHYIAEAEINSMSWKVSLE 568
            .|.|..|          |....|:.|||.|::.:|   |..|::..|:|
Zfish   414 NDSPSKG----------LSVIEIIVIVLCTVIGIMGTLAFIFYWQNRYY---------------- 452

  Fly   569 DVMFRDAAERGLRGSFHSLVKQ----SSQLTLMSE----DMVSINGDRQ------IFIPVGMFRK 619
                            |.:.|:    ||||....|    :|:|:..:..      ..:....:.|
Zfish   453 ----------------HHMQKRWSHISSQLITPLELNEWNMISLKIEEDSTENSTYILRRARYDK 501

  Fly   620 SKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDIL 684
            ..|.:|  |.....|..|....:||..:..:.:.:|.||||........|.:.||..:|||:.:|
Zfish   502 KIVILK--EFRLTDGSFTEKQRIELNTLLKIDYCNLTKFYGTVKFDNEYFGVFEYGERGSLRYVL 564

  Fly   685 EN-----EQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTL 744
            ::     |:..:||.|::|:|:||.:||.:||:|:|..||.|||:|||||:|.|:||.|||.:|:
Zfish   565 DDKISYPEETFMDWQFKISVMYDIAKGMSYLHTSNIAVHGRLKSTNCVVDNRMVVKIADFGFNTI 629

  Fly   745 RRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFY 809
            .....|                 |||||     ||.|.|..:||||||:|.||..||..|:..||
Zfish   630 VSPSED-----------------LWTAP-----EHLRKPGISQKGDVYSFAIISQEIMMRKCTFY 672

  Fly   810 LGRCA--YEKSPQEIIELVKGYNPHRMQKP-----FRPEL--EPNGDTKADINGIIRRCWAEDPA 865
            ...|:  .||..             |:|.|     |||:|  |...:::.::..:||.||.|||.
Zfish   673 TNTCSDRAEKLA-------------RVQYPSTTSFFRPDLNFESTSESEEEVCMLIRNCWDEDPD 724

  Fly   866 ERPDFNTLK----SMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLL 926
            .||||..::    .::.|.|:::|  :.::||::|:::|:.|||.||||||..|..|:.:.:.|.
Zfish   725 RRPDFKKIEIALWKIVSRDNQEHE--SYMENLIRRLQMYSRNLERLVEERTALYKAERDRADCLN 787

  Fly   927 YQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVEN 991
            :.|||..|...|.....|..|.||:||||||||||||.:...||||:||..|||:|..||||::|
Zfish   788 FMLLPGPVVRSLKETGKVEPELFDEVTIYFSDIVGFTTLCHFSTPMEVVDMLNDIYKNFDSILDN 852

  Fly   992 FDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGA 1056
            .|||||||||||||||||||.||||:||::|..:||.:|..:...::.|.|...:.:|||:|:|.
Zfish   853 HDVYKVETIGDAYMVVSGLPRRNGNRHAKDICLMALDILAFMGTIQLSHLPGIPVWIRIGVHSGP 917

  Fly  1057 CVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFG-TFVTTRRGFVPMKGK 1120
            |.|||||:||||||||||||||||||||.|..|:||:|::|...|.... .|....||...:|||
Zfish   918 CAAGVVGIKMPRYCLFGDTVNTASRMESTGLPLRIHVSQSTINILQRTDCKFEYEERGETFLKGK 982

  Fly  1121 GEMLTYWLEGEVPRPNSLISPSKLMLTRRSSLKQPQRSQSHNLHKQYSELV 1171
            |:.:||||.|......:|.:|             |......||.:..||::
Zfish   983 GKEMTYWLTGVTGENYNLPTP-------------PTAENFQNLQQDLSEMI 1020

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	91/443 (21%)
		ANF_receptor	108..473	CDD:279440	84/395 (21%)
		PK_GC-A_B	589..883	CDD:270944	108/325 (33%)
		Pkinase_Tyr	613..877	CDD:285015	98/281 (35%)
		HNOBA	<893..938	CDD:285003	19/44 (43%)
		CYCc	917..1108	CDD:214485	107/191 (56%)
		Guanylate_cyc	944..1130	CDD:278633	111/186 (60%)
gucy2cb	XP_021329920.1	Periplasmic_Binding_Protein_Type_1	33..408	CDD:324556	91/444 (20%)
		PKc_like	471..741	CDD:328722	101/306 (33%)
		CYCc	778..970	CDD:214485	107/191 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.920