DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and adcy6b

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_002666536.2	Gene:	adcy6b / 560807	ZFINID:	ZDB-GENE-090127-2	Length:	1174	Species:	Danio rerio

Alignment Length:	993	Identity:	198/993 - (19%)
Similarity:	350/993 - (35%)	Gaps:	346/993 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   235 LIYQNENAKVKGNSVCFLCLAAIHDTIEEHS--VYQLGFDTSTWTKADITRMLKNVAMQSRIVIM 297
            |.::|...::|....|:.|::.:.:...:|:  ..::|.|           |::.:::
Zfish   422 LAWENHCLRIKILGDCYYCVSGLPEPRADHAHCCVEMGVD-----------MIEAISL------- 468

  Fly   298 CADPQSIRQIMLTAEELNM---IDSGEYVFINIELFSRVQ--YLTSQPW-YD--KNDTDLNN--E 352
                  :|::  |...:||   |.||           ||.  .|..:.| :|  .||..|.|  |
Zfish   469 ------VREV--TGVNVNMRVGIHSG-----------RVHCGVLGLRKWQFDVWSNDVTLANQME 514

  Fly   353 RAQKAYTAMLTVTPKQPNDNEYTRVSNEIKA-IAAEKYNYTFSDNEPISAFVTSFFDGVLLYANA 416
            ...||....:|....|..:.:|     |::| ...::..|..::|      :.:||  ||    .
Zfish   515 AGGKAGRIHITKATLQYLNGDY-----EVEAGFGGDRNAYLNNNN------IETFF--VL----G 562

  Fly   417 LNESIREDPTMLTR----PINGTDMVRRMW--NRSF-----TGITGNVTIDANGDRLSAYSLLDM 470
            .::..:|:..|:.:    ..|.::.:...|  :|||     :.:...:.||....:.:..:...:
Zfish   563 CSQKRKEEKAMMAKMQRARANSSEGLMPRWVPDRSFSRTKDSKVFRQMGIDEASSKDNRCAQEAL 627

  Fly   471 NPTTGRFEIVAHFLHNR---------------------LEFEANKEIHWAGDREEAPPDRPICGY 514
            ||.....|.:...:..|                     ||.:.:|::
Zfish   628 NPEDEVDEFLGRAIDARSIDQLRKDHVKKFLLTFQTPLLEKKYSKKV------------------ 674

  Fly   515 DGALCPDNSLPGYAILSIVLGTMVV-VMAVCF-------------FFGYRHYIAEAEINSMSWKV 565
                  |:...||...::::...:| :..|.|             |....|.:....|.|.   |
Zfish   675 ------DDRFGGYVACTLLVFCFIVFIQIVIFPHTPLMLGLFITIFIILAHVLFICAIYSC---V 730

  Fly   566 SLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMVSINGDRQIFIP--VGMF---RKSKVAIK 625
            .|..|..:..::|        :|:.....||:....:.:     :||.  |.||   |...:|..
Zfish   731 KLFPVTLQTVSKR--------IVQSRINSTLVGVFTILL-----LFISAFVNMFTCDRTDMLACV 782

  Fly   626 PVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQ 690
            ...: |:...:|..|:..|   ..|..|   .|: .||||..:..|.||
Zfish   783 AGHL-NISESVTLCLLYNL---SGLAED---PFF-LCLDQPSACPLPEY---------------- 823

  Fly   691 LDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLK----SSNC-----------VVDSRFVLKITDFG 740
                |..|::..::....|||.|.|   |.|.    ...|           ::|:..:|...| .
Zfish   824 ----FTYSVLLTLLCCSVFLHISSI---GKLVLMLFIQICFLLLIEWPLVSLLDNADLLDTVD-A 880

  Fly   741 LHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQ 805
            |:....|.:        |........|..:.|.:|              .|:...:.:|
Zfish   881 LYAFNETNY--------CQETVTKVSLRVSIPVIL--------------TVFVLALYLH------ 917

  Fly   806 GPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDF 870
                         .|::                                        :...|.||
Zfish   918 -------------AQQV----------------------------------------ESTARLDF 929

  Fly   871 NTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVA 935
                                     ..:|.|...:|.:|| .|.|:      .:||:.:||:.||
Zfish   930 -------------------------LWKLQATEEKEEMEE-LQAYN------RRLLHNILPKDVA 962

  Fly   936 AQLISGQPVVAETFDQ----VTIYFSDIVGF----TAISAESTPMQVVQFLNDLYTCFDSIV--E 990
            |..::.:....|.:.|    |.:.|:.|..|    |.:.|.:..::.::.||::...||.|:  |
Zfish   963 AHFLARERRNDELYYQSCECVAVMFASISNFSEFYTELEANNEGVECLRLLNEIIADFDEIISEE 1027

  Fly   991 NF-DVYKVETIGDAYMVVSGLP----IRNGNQHAREIARLALALLEAV-----HNFRIHHRPEDR 1045
            .: .:.|::|||..||..|||.    .:.|..|...:|..|:.|.|.:     |:|       :.
Zfish  1028 KYKQLEKIKTIGSTYMAASGLNDSTYDKEGRTHILALADYAMRLREQMKYINEHSF-------NN 1085

  Fly  1046 LKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTT 1110
            .:::|||:.|..||||:|.:.|:|.::|:|||.||||:|.|...:|.::......|:..| :...
Zfish  1086 FQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDSTGVPDRIQVTTDLYHVLESKG-YQLE 1149

  Fly  1111 RRGFVPMKGKGEMLTYWL 1128
            .||.|.:||||:|.||:|
Zfish  1150 CRGLVKVKGKGDMTTYFL 1167

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	55/307 (18%)
		ANF_receptor	108..473	CDD:279440	49/261 (19%)
		PK_GC-A_B	589..883	CDD:270944	48/313 (15%)
		Pkinase_Tyr	613..877	CDD:285015	44/283 (16%)
		HNOBA	<893..938	CDD:285003	14/44 (32%)
		CYCc	917..1108	CDD:214485	62/210 (30%)
		Guanylate_cyc	944..1130	CDD:278633	66/205 (32%)
adcy6b	XP_002666536.2	AC_N	15..376	CDD:318454
		Guanylate_cyc	378..562	CDD:306677	39/193 (20%)
		DUF1053	590..677	CDD:310728	14/110 (13%)
		Guanylate_cyc	975..1169	CDD:306677	65/201 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.900