DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and npr1a

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001038402.1	Gene:	npr1a / 560653	ZFINID:	ZDB-GENE-060503-539	Length:	1067	Species:	Danio rerio

Alignment Length:	1125	Identity:	472/1125 - (41%)
Similarity:	677/1125 - (60%)	Gaps:	131/1125 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    52 PETKNSHKSQSTELVQHFPSLPMPDHRRLGARRQLVFVALLPSVESDNKNDCIMPKVLPVLELAI 116
            |::.::|.||                      :.:....:||.  .:.:.....|:|.|.|..|:
Zfish    35 PQSPSAHASQ----------------------KNITLAVILPL--HNTEYPWAWPRVGPALYWAL 75

  Fly   117 RHVQR-MGFVGGSHFDIQLI-----SRDTFCSSKYGPIGFFEI---YTQWPEVNAVFGLPCEYVL 172
            ..|.. ...:.|.|  :||:     :::..||....|:...::   |..|    |..|..|:|..
Zfish    76 EKVNSDPNLLAGYH--LQLVFNSSENKEGLCSDSVAPLVAVDLKFSYNPW----AFIGPGCDYSS 134

  Fly   173 APISRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIY 237
            :|::|:...|:||::|:|..|..||    .||::|.: |.....||..|..:...|.|.:.|::.
Zfish   135 SPVARFTTHWEVPMITSGARALGFN----LYSSITNI-GPTHKKLGEFVLRMHRHFGWDKHAMLM 194

  Fly   238 QNENAKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTKADIT-----------RMLKNVAMQ 291
            .|:|.  ..:..|:..:...:..:.|.::          |..|:.           .:|::::.:
Zfish   195 FNDNK--NDDRPCYFAVEGPYTQMREDNI----------TADDLVFNEDEEPLRYDELLRDISHK 247

  Fly   292 SRIVIMCADPQSIRQIMLT------AEELNMIDSGEYVFINIELFSR-VQYLTSQPWYDKNDTDL 349
            :|:|.:|...::.|::|:.      .:|       ||.|..|:||.| :|...::|| .:.|.|.
Zfish   248 ARVVYVCCKWETFRKLMVEFWRQGFPQE-------EYAFFFIDLFGRSLQSHPARPW-ARGDADD 304

  Fly   350 NNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYA 414
            |  .|::|:.::..:|.::|.:.||....:::|..|.:.:|:...|: .::....||.|||:||:
Zfish   305 N--AAKEAFKSVKILTYREPQNPEYKDFVSKLKTEAMDMFNFNVEDS-LMNLISGSFHDGVMLYS 366

  Fly   415 NALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPT-TGRFE 478
            :|||:::....   :|| .|..:.:|||||::.|:||.|.:|.||||...::|.||..| ||.::
Zfish   367 HALNDTMDRSG---SRP-PGDVVNKRMWNRTYHGVTGLVQLDENGDREIDFALWDMTDTKTGDYQ 427

  Fly   479 IVAHF--LHNRLEFEANKEIHWAGDREEAPPDRPICGY--DGALCPDNSLPGYAILSIVLGTMVV 539
            ||:.:  ...::..|...::||...|  .|||.|.||:  |...|...::..:.::|||:..:.:
Zfish   428 IVSVYNGSQKQMILEPGMKVHWLKGR--PPPDIPECGFKNDNPACLAKTVTMHQMISIVVCFIFI 490

  Fly   540 VMAVCFFFGYRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSE----- 599
            ::.....|.||....|.|:.:..|:|..||:...: .|:.||       :..|:||:...
Zfish   491 IIVTVTVFIYRKLKLENELTAQLWRVHWEDIQMSN-TEKVLR-------RACSKLTISLRGSNYG 547

  Fly   600 DMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLD 664
            .:::::|:.||:...|.::.:..|||.|....::  |||.::.|||.|:|:|::||.:|.|||:|
Zfish   548 SLLTMDGNFQIYAKTGYYKGNITAIKYVNKKRIE--LTRKVLFELKHMRDVQNEHLTRFIGACID 610

  Fly   665 QRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVD 729
            .....:||||||:|||||::|:|...||||||.||::|||:||.|||:|.|.|||||||||||||
Zfish   611 PPNICILTEYCPRGSLQDLMESEGITLDWMFRYSLINDIVKGMAFLHNSVIVSHGNLKSSNCVVD 675

  Fly   730 SRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAF 794
            |||||||||:||.:..:       |....:.||::::.|||||||||.: |.|..||||||||:|
Zfish   676 SRFVLKITDYGLESFHK-------DSNLDDVHAFYARQLWTAPELLRAD-NPPACGTQKGDVYSF 732

  Fly   795 GIIVHEITTRQGPFYL-GRCAYEKSPQEIIE-LVKGYNPHRMQKPFRPELEPNGDTKADINGIIR 857
            |||:.|:...:|.||| |.|.   ||:|||| :|:|..|:     .||.|.|...:: ::..::.
Zfish   733 GIILQELALLKGVFYLEGPCL---SPKEIIERVVEGRWPY-----LRPLLCPQSHSE-EMGQLML 788

  Fly   858 RCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKC 922
            |||:||..|||||:.:|.::|: |......||:||||.|||.||||||||||||||.|||||:|.
Zfish   789 RCWSEDVNERPDFSQIKVLLRK-NNCGYGSNILDNLLSRMEQYANNLEELVEERTQAYHEEKRKA 852

  Fly   923 EKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDS 987
            |.||||:||.|||.||..|:.|.||.||.|||||||||||||:|||||||:||..|||||||||:
Zfish   853 EALLYQILPHSVAEQLKRGEMVQAEAFDSVTIYFSDIVGFTALSAESTPMEVVTLLNDLYTCFDA 917

  Fly   988 IVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGL 1052
            |::|||||||||||||||||||||:|||..|||||||::||||||||:|||.|||..:|:||||:
Zfish   918 IIDNFDVYKVETIGDAYMVVSGLPVRNGKLHAREIARMSLALLEAVHSFRIRHRPNLQLRLRIGI 982

  Fly  1053 HTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPM 1117
            |:|...||||||||||||||||||||||||||||||||||:||.|:..|.||..|....||.|.|
Zfish   983 HSGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHVSEATRAVLQEFNCFQLELRGDVEM 1047

  Fly  1118 KGKGEMLTYWLEGEVPRPNS 1137
            ||||.|.||||.||:...|:
Zfish  1048 KGKGRMRTYWLLGEISSNNA 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	113/439 (26%)
		ANF_receptor	108..473	CDD:279440	104/391 (27%)
		PK_GC-A_B	589..883	CDD:270944	141/300 (47%)
		Pkinase_Tyr	613..877	CDD:285015	133/265 (50%)
		HNOBA	<893..938	CDD:285003	35/44 (80%)
		CYCc	917..1108	CDD:214485	146/190 (77%)
		Guanylate_cyc	944..1130	CDD:278633	143/185 (77%)
npr1a	NP_001038402.1	PBP1_NPR_A	48..449	CDD:107380	113/440 (26%)
		ANF_receptor	66..421	CDD:279440	104/392 (27%)
		PK_GC-A_B	540..814	CDD:270944	138/293 (47%)
		TyrKc	554..808	CDD:197581	136/272 (50%)
		HNOBA	<823..868	CDD:285003	35/44 (80%)
		CYCc	847..1032	CDD:214485	143/184 (78%)
		Guanylate_cyc	874..1060	CDD:278633	143/185 (77%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I1494
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	784	1.000	Inparanoid score	I500
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002376
OrthoInspector	1	1.000	-	-		otm25592
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5404
SonicParanoid	1	1.000	-	-		X2472
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.760