DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and ADCY10

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_060887.2	Gene:	ADCY10 / 55811	HGNCID:	21285	Length:	1610	Species:	Homo sapiens

Alignment Length:	896	Identity:	152/896 - (16%)
Similarity:	277/896 - (30%)	Gaps:	303/896 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 EIYTQWPEVNAVFGLPCEYVLA------PISRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRL- 209
            |.:..||.|.....||...|..      |...|.|...:.|..:|     |...:|.:|:...:
Human     6 EEFQDWPIVRIAAHLPDLIVYGHFSPERPFMDYFDGVLMFVDISG-----FTAMTEKFSSAMYMD 65

  Fly   210 KGAQ--VNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFL-----------CLAAIHDTI 261
            :||:  |..|...:.||:..      .||:..:..|..|:::..|           ....|..::
Human    66 RGAEQLVEILNYHISAIVEK------VLIFGGDILKFAGDALLALWRVERKQLKNIITVVIKCSL 124

  Fly   262 EEHSVYQLGFDTSTWTK----------------------------------ADITRMLKNVAMQS 292
            |.|.:    |:|..|.:                                  .|..|:.:|:|..:
Human   125 EIHGL----FETQEWEEGLDIRVKIGLAAGHISMLVFGDETHSHFLVIGQAVDDVRLAQNMAQMN 185

  Fly   293 RIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINI----------ELFSRVQYLTSQPWYD---- 343
            .:::   .|...:....:..|:..:.....|.:|.          |.|::.  .|...:|.
Human   186 DVIL---SPNCWQLCDRSMIEIESVPDQRAVKVNFLKPPPNFNFDEFFTKC--TTFMHYYPSGEH 245

  Fly   344 ----------KNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEP 398
                      |.|.:|.....:....::|    ||.::.:.....:|::.:.....|..|.|.:.
Human   246 KNLLRLACTLKPDPELEMSLQKYVMESIL----KQIDNKQLQGYLSELRPVTIVFVNLMFEDQDK 306

  Fly   399 ISAF----------VTS---------------------------------------------FFD 408
            ....          :||                                             .||
Human   307 AEEIGPAIQDAYMHITSVLKIFQGQINKVFMFDKGCSFLCVFGFPGEKVPDELTHALECAMDIFD 371

  Fly   409 -------------GV---LLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDA 457
                         ||   :::...:..::|.:.|::.:.:|   :..||. ..:.||....::..
Human   372 FCSQVHKIQTVSIGVASGIVFCGIVGHTVRHEYTVIGQKVN---LAARMM-MYYPGIVTCDSVTY 432

  Fly   458 NGDRLSAY-----------SLLDMNPT---TGRFEIV----AHFLHNRLE----FEANKEIH--- 497
            ||..|.||           .:.|..|.   .||.|.|    |..:.||.|    ...||||:
Human   433 NGSNLPAYFFKELPKKVMKGVADSGPLYQYWGRTEKVMFGMACLICNRKEDYPLLGRNKEINYFM 497

  Fly   498 WAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFF-GYRHYIAEAEINSM 561
            :...:........:..|:|       ||||       |...::|.:.:.. |..|.|....:|.:
Human   498 YTMKKFLISNSSQVLMYEG-------LPGY-------GKSQILMKIEYLAQGKNHRIIAISLNKI 548

  Fly   562 SWKVSLEDVMFRDAAERGLRGSFHSLVKQSS----QLTLMSEDMVSINGDRQIFIPVGMFRKSKV 622
            |:..:...:....|...||....|...:|::    .:||:.|....:..|  ||
Human   549 SFHQTFYTIQMFMANVLGLDTCKHYKERQTNLRNKVMTLLDEKFYCLLND--IF----------- 600

  Fly   623 AIKPVEVDNVQGLLTR--SLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILE 685
                    :||..::|  |.|..||:.|.|: ...:|.....:.:.|...            |::
Human   601 --------HVQFPISREISRMSTLKKQKQLE-ILFMKILKLIVKEERIIF------------IID 644

  Fly   686 NEQF--QLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNL--KSSNCVVDSRFVLKIT--------- 737
            ..||  ...|.|    |..::|.:.......:....|:  .::..|:.:|....|.
Human   645 EAQFVDSTSWRF----MEKLIRTLPIFIIMSLCPFVNIPCAAARAVIKNRNTTYIVIGAVQPNDI 705

  Fly   738 ------DFGLHTLRRTRFDLES--DGGNCNSHAYWSKLLWTAP--ELLRVEHNRPPEGTQK--GD 790
                  |..:..:.:   :|:|  ..|:|....|..:||....  |:|..:.....|.|.:  .:
Human   706 SNKICLDLNVSCISK---ELDSYLGEGSCGIPFYCEELLKNLEHHEVLVFQQTESEEKTNRTWNN 767

  Fly   791 VYAFGIIVHE----ITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKP 837
            ::.:.|.:.|    :|...          :|..:|:..|..|.....:..|
Human   768 LFKYSIKLTEKLNMVTLHS----------DKESEEVCHLTSGVRLKNLSPP 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	86/519 (17%)
		ANF_receptor	108..473	CDD:279440	73/480 (15%)
		PK_GC-A_B	589..883	CDD:270944	49/284 (17%)
		Pkinase_Tyr	613..877	CDD:285015	42/256 (16%)
		HNOBA	<893..938	CDD:285003
		CYCc	917..1108	CDD:214485
		Guanylate_cyc	944..1130	CDD:278633
ADCY10	NP_060887.2	CHD	40..214	CDD:143636	29/191 (15%)
		AcyC	<42..197	CDD:225025	27/172 (16%)
		CHD	292..461	CDD:143636	23/172 (13%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900