DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and npr1b

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_009290669.2	Gene:	npr1b / 555911	ZFINID:	ZDB-GENE-100805-4	Length:	1070	Species:	Danio rerio

Alignment Length:	1154	Identity:	477/1154 - (41%)
Similarity:	679/1154 - (58%)	Gaps:	131/1154 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LSLLLILCLLQAHLFPSAAWFYDAESVGGVASIGVGSDEHSFKTPETKNSHK---SQSTELV--- 66
            |.|||:.|                    |..|......:|       :.|||   :.|.::|
Zfish    15 LPLLLLCC--------------------GTLSTWTKISKH-------QGSHKGAHNHSNDIVLAV 52

  Fly    67 ---QHFPSLPMPDHRRLGARRQLVFVALLPSVESDNKNDCIMPKVLPVLELAIRHVQRMGFVGGS 128
               ||..|.|....|        |..||..::...|.|    |.:||      ||..|..|....
Zfish    53 ILPQHNTSYPWAWPR--------VGPALDRAIARVNAN----PNLLP------RHRVRHVFANSE 99

  Fly   129 HFDIQLISRDTFCSSKYGPIGFFEI---YTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTG 190
                   .||..||....|:...::   :..|    |..|..|:|..:|:..:...|.:|::|.|
Zfish   100 -------DRDGICSESMAPLMAVDLKFEHNPW----AFIGPGCDYTSSPVGLFTAHWGLPMITAG 153

  Fly   191 GNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLA 255
            ..|..| .:.|.|:::|. .|.....||.....:...|.|.:.:|:..::..  .|...|:..|.
Zfish   154 APAVAF-LQMEIYTSITN-TGPTHKKLGEYALHLYRHFGWNQHSLLMFSDTK--MGERACYFALE 214

  Fly   256 AIHDTIEEHSV--YQLGFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMID 318
            .::..:.|.::  ..|.|:.:. ...:.:.:|..:....|:|.:|..|...||:::...:.. :.
Zfish   215 GLYTEMHEENITTMDLVFEENK-GPVNYSELLHKIQGDGRVVFVCCSPDVFRQLIVHFHKAG-LP 277

  Fly   319 SGEYVFINIELFSR-VQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIK 382
            ..||||..|::|.. .:...|||| .:.|:|  :..|::|:.::..:|..:|.:.||.....::|
Zfish   278 KEEYVFFYIDIFGHSFRSRPSQPW-ARGDSD--DVFAKEAFQSVKILTYLEPQNQEYKDFVTDLK 339

  Fly   383 AIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFT 447
            :.|...:|:|. |:..::.....|:||::||.:|||||:.:..   .|| :|..:.:|||||::.
Zfish   340 SDAKRMFNFTV-DDSLMNIISGGFYDGLMLYCHALNESLSDSH---ERP-SGESVSKRMWNRTYY 399

  Fly   448 GITGNVTIDANGDRLSAYSLLDM-NPTTGRFEIVAHFLHNRLEFEAN----KEIHWAGDREEAPP 507
            |:||.|.||.||||.:.::|.|| :..||.|:|||  ::|..:.|.|    ..|.|.|.:  .|.
Zfish   400 GVTGLVQIDENGDRETDFALWDMADINTGDFQIVA--VYNGTQKEMNILPGMAIQWPGGK--VPM 460

  Fly   508 DRPICGY--DGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEINSMSWKVSLEDV 570
            |.|.||:  :...|...::..:.::||||..:::::.....|.||....|.|:.:..|::|.:|:
Zfish   461 DVPTCGFKNENPACRARTIAMHQMISIVLFLILIIIFTVTVFIYRKLKLEKELVAQLWRISWDDI 525

  Fly   571 MFRDAAERGLRGSFHSLVKQSSQLTLMSE-----DMVSINGDRQIFIPVGMFRKSKVAIKPVEVD 630
            .. ...|:.||.:       .|:|||...     .:::.:|:.|:|...|.|:.:.||||.:...
Zfish   526 QM-SHLEKALRST-------GSKLTLSLRGSNYGSLLTTDGNFQVFAKTGYFKGNIVAIKYINRR 582

  Fly   631 NVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMF 695
            .|:  |||.::.|||.|:|:|::||.:|.|||:|.....::|||||:||||:||||:...|||||
Zfish   583 RVE--LTRKVLFELKHMRDVQNEHLTRFIGACIDPPNICIVTEYCPRGSLQNILENDSITLDWMF 645

  Fly   696 RLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNS 760
            :.||:.|||:||.|||:|.|.|||||||||||||:||||||||:||.:: ||..|.|      ::
Zfish   646 KYSLISDIVKGMAFLHNSVIVSHGNLKSSNCVVDNRFVLKITDYGLSSI-RTESDTE------DA 703

  Fly   761 HAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYL-GRCAYEKSPQEIIE 824
            |:|:::.||.||||.|:| ..||.||||||||:||||:.|:..|:|.||| |...   ||:||::
Zfish   704 HSYYARKLWLAPELSRME-CFPPGGTQKGDVYSFGIILQEVALRRGVFYLEGDLL---SPKEIVD 764

  Fly   825 LVK-GYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGN 888
            .|. |..|:     .||.|.|...:: ::..:::|||||:|::||:|:.:..::|:.|:::.: |
Zfish   765 RVALGEWPY-----LRPSLNPQAHSE-ELGQLMQRCWAEEPSDRPEFSHISVLLRKQNREHRS-N 822

  Fly   889 IVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVT 953
            |:||||.|||.||||||||||||||.|.|||:|.|.||||:||.|||.||..|:.|.||.||.||
Zfish   823 ILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVT 887

  Fly   954 IYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQH 1018
            ||||||||||::||||||:|||..|||||||||:|::|||||||||||||||||||||:|||..|
Zfish   888 IYFSDIVGFTSLSAESTPLQVVTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPVRNGKLH 952

  Fly  1019 AREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRME 1083
            .|||||::|||||||..|:|.|||:::||||||:|:|...||||||||||||||||||||:||||
Zfish   953 GREIARMSLALLEAVKTFKIRHRPDEQLKLRIGIHSGPVCAGVVGLKMPRYCLFGDTVNTSSRME 1017

  Fly  1084 SNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGEV 1132
            ||||.||||:|..|:..|.||..|....||.|.|||||:|.||||.|||
Zfish  1018 SNGEPLKIHVSSATRAVLQEFNCFQLELRGDVEMKGKGKMRTYWLLGEV 1066

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	114/420 (27%)
		ANF_receptor	108..473	CDD:279440	99/371 (27%)
		PK_GC-A_B	589..883	CDD:270944	140/300 (47%)
		Pkinase_Tyr	613..877	CDD:285015	131/265 (49%)
		HNOBA	<893..938	CDD:285003	34/44 (77%)
		CYCc	917..1108	CDD:214485	140/190 (74%)
		Guanylate_cyc	944..1130	CDD:278633	137/185 (74%)
npr1b	XP_009290669.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	292	1.000	Domainoid score	I1494
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	784	1.000	Inparanoid score	I500
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002376
OrthoInspector	1	1.000	-	-		otm25592
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5404
SonicParanoid	1	1.000	-	-		X2472
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.760