DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and Phlpp2

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001102601.2	Gene:	Phlpp2 / 498949	RGDID:	1562857	Length:	1359	Species:	Rattus norvegicus

Alignment Length:	1162	Identity:	214/1162 - (18%)
Similarity:	353/1162 - (30%)	Gaps:	468/1162 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly   442 WNRSFTGITGN--VTIDANGDRLSAYSLLDMNPTTGRFEIVAHFL-----------HNRLEFEAN 493
            |.|..:.:...  .|:|     ||.|||         .|:..|..           ||.::.|
  Rat   275 WQRQASKVVSQRISTVD-----LSCYSL---------EEVPEHLFYSQDITYLNLRHNFMQLE-- 323

  Fly   494 KEIHWAGDREEAPPDRPICGYDGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYIAEAEI 558
                           || .|.| .|...:.|.|..:....||...|::              .||
  Rat   324 ---------------RP-GGLD-TLYKFSQLKGLNLSHNKLGLFPVLL--------------CEI 357

  Fly   559 NSMSWKVSLEDVMFRD-AAERGLRGSFHSLVKQSSQLTLMSEDM----------VSINGDRQI-- 610
            :::: :::|....|.| .::.|...:..:|....:.||.:.:::          :|.|...||
  Rat   358 STLT-ELNLSCNGFHDLPSQIGNLLNLQTLCLDGNVLTALPDELGNLQQLTSLGISFNNFSQIPE 421

  Fly   611 -FIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEY 674
             ...:.|..|..:|...:|:.|: |:|||  |..:|.: ||:.:||
  Rat   422 VLEKLTMLDKVVMAGNRLEILNL-GVLTR--MNHVKHV-DLRMNHL------------------- 463

  Fly   675 CPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDF 739
              |..:.:.||..:         .:.|..:|..| |...|:.|..:|:..:|..:....|.::.|
  Rat   464 --KTVIIENLEGNK---------HITHMDLRDNQ-LTDLDLSSLCSLEQLHCERNQLRELTLSGF 516

  Fly   740 GLHTLRRTRFDLESDGGNCNSHAYWSKLL--------------------------WTAP----EL 774
            .|.                |.:|.|:||.                          |...    |:
  Rat   517 SLR----------------NLYANWNKLTAVNVYPVPSLLTSLELSRNLLECIPDWACEAKKLEI 565

  Fly   775 LRVEHNRPPEGTQK--------------GDVYAFGIIVHEI----------TTRQGPFYL----- 810
            |.:.:|...|...:              ..::....:|..|          |..:.|..|
  Rat   566 LDISYNLLTEVPMRILSSLSLRKLMVGHNHIHVLPALVEHIPLEVLDVQHNTLSRLPDTLFSKAL 630

  Fly   811 ----------------GRCAYEKS--------------PQEIIELVKGYNPH-RMQKPFRPELEP 844
                            ..||.|:|              ..:.|.::.|: || |:......:|:
  Rat   631 NLRYLNASANSLESLPSACAGEESLSVLQLLYLTNNLLTDQCIPVLVGH-PHLRVLHLANNQLQ- 693

  Fly   845 NGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLK-------------R 896
                             ..||.:  .|.|:.:        |..|:..|.||             .
  Rat   694 -----------------TFPASK--LNKLEQL--------EELNLSGNKLKAIPTTIANCKRLHT 731

  Fly   897 MELYANNLE------ELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQL----ISGQP-VVAE--T 948
            :..:|||:.      :|.:.:..|.     .|..|...|:|:::.|.|    ::|.. :|.|  |
  Rat   732 LVAHANNISIFPEILQLPQIQFVDL-----SCNDLTEILIPETLPATLQDLDLTGNTNLVLEHKT 791

  Fly   949 FDQVTIYFSDIVGFTAISAESTPM-----------------QVVQFLNDLYTCFDSI-VENFDVY 995
            .|.    ||.|   |.:..:..|:                 ::....|.|  |..:: ::||
  Rat   792 LDM----FSHI---TTLKIDQKPLPTTDSTVTSTFWSHGLAEMAGQRNKL--CVSALAMDNF--- 844

  Fly   996 KVETIGDAYMVVSGLPIRNGNQHAREIARLALA--LLEAV-----------HNFRIHHR------ 1041
             .|.:|..|.:..|    :.|:....:.:..:|  |||.|           :.|.:.||
  Rat   845 -AEGVGAVYGMFDG----DRNEELPRLLQCTMADVLLEEVQHSTSDTVFMANTFLVSHRKLGMAG 904

  Fly  1042 ------------------PEDRLKLRIGLHTGACVAGVV--GLKMPRYCLFG--DTVNTASRMES 1084
                              |.....|.:. :.|.|.|.:.  |..:|...:|.  .....|.|::.
  Rat   905 QKLGSSALLCYIRPDTADPTSSFSLTVA-NVGTCQAVLCRGGKPVPLSKVFSLEHDPEEAQRVKD 968

  Fly  1085 NGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLISP----SKLM 1145
            .    |..|:|..|..    |....||     |.|    .||.....:|:|:...:|    .:|:
  Rat   969 Q----KAIITEDNKVN----GVTCCTR-----MLG----CTYLYPWILPKPHISSTPLTIQDELL 1016

  Fly  1146 LTRRSSLKQPQRSQSHNLHKQYSELVVASPPPQLPPPAIALPPPPSPSKDSPNLRVKRKISSSSP 1210
            :....:|.:         |..|.|.|.|
  Rat  1017 ILGNKALWE---------HLSYLEAVSA------------------------------------- 1035

  Fly  1211 KLNGGGFDYHKTENHYLDTAAAAQRNCDIYSSRSLRDMEETSDSWELAHFRLPLSGALKSHHHLN 1275
                        ..|..|..|||::.|.:..|...:|.                .||:..  :||
  Rat  1036 ------------VRHVQDPLAAAKKLCTLAQSYGCQDN----------------VGAMVV--YLN 1070

  Fly  1276 NNSHGYVHSNSSSNLSGILQPPPLGVQRT---RLKPSPTI----STLLTSARSEANASP-GPETG 1332
            ....|     .:..:.|:..|.|:|...|   :..|.||.    |.:.:...||.:.|. ..|.|
  Rat  1071 IGEEG-----CTCEMHGLALPGPVGFASTATIKDAPKPTTPSSSSGIASELSSEVSTSEVSSEVG 1130

  Fly  1333 SMGSGQLRIKFAEGDETPLLPTPPPLAAPPPIPQMVAASPQRSGSGQNIPADSSHYG 1389
            |..|.:..   ..|.||.|||.|....:..|:|.  |.:.||..|.....::.|..|
  Rat  1131 STASDEHN---TVGLETSLLPRPERRCSLHPVPS--AGTFQRQPSCATFSSNQSDNG 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	14/68 (21%)
		ANF_receptor	108..473	CDD:279440	9/32 (28%)
		PK_GC-A_B	589..883	CDD:270944	64/396 (16%)
		Pkinase_Tyr	613..877	CDD:285015	58/353 (16%)
		HNOBA	<893..938	CDD:285003	12/63 (19%)
		CYCc	917..1108	CDD:214485	49/256 (19%)
		Guanylate_cyc	944..1130	CDD:278633	48/246 (20%)
Phlpp2	NP_001102601.2	RA_PHLPP2	66..178	CDD:340761
		PH_PHLPP-like	185..279	CDD:270131	2/3 (67%)
		PLN00113	284..>762	CDD:215061	104/610 (17%)
		leucine-rich repeat	289..309	CDD:275380	9/33 (27%)
		leucine-rich repeat	310..336	CDD:275380	8/44 (18%)
		leucine-rich repeat	337..359	CDD:275380	7/35 (20%)
		leucine-rich repeat	360..382	CDD:275380	4/22 (18%)
		leucine-rich repeat	383..405	CDD:275380	3/21 (14%)
		leucine-rich repeat	406..428	CDD:275380	4/21 (19%)
		leucine-rich repeat	429..452	CDD:275380	9/25 (36%)
		leucine-rich repeat	453..476	CDD:275380	8/53 (15%)
		leucine-rich repeat	477..497	CDD:275380	6/20 (30%)
		leucine-rich repeat	498..517	CDD:275380	3/18 (17%)
		leucine-rich repeat	518..539	CDD:275380	6/36 (17%)
		leucine-rich repeat	540..562	CDD:275380	1/21 (5%)
		leucine-rich repeat	563..584	CDD:275380	4/20 (20%)
		leucine-rich repeat	586..607	CDD:275380	1/20 (5%)
		leucine-rich repeat	608..631	CDD:275380	3/22 (14%)
		leucine-rich repeat	632..681	CDD:275380	6/49 (12%)
		leucine-rich repeat	682..705	CDD:275380	6/42 (14%)
		leucine-rich repeat	706..728	CDD:275380	5/29 (17%)
		leucine-rich repeat	751..772	CDD:275380	5/25 (20%)
		PP2Cc	820..1069	CDD:238083	59/352 (17%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900