DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and Gucy1a1

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_058786.2	Gene:	Gucy1a1 / 497757	RGDID:	68436	Length:	690	Species:	Rattus norvegicus

Alignment Length:	245	Identity:	109/245 - (44%)
Similarity:	143/245 - (58%)	Gaps:	11/245 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   868 PDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQ 932
            |..|.|:.::    ...|.....|.|.||:    ..|:..:|...|...|||||...||..:.|.
  Rat   403 PIHNALRDVV----LIGEQARAQDGLKKRL----GKLKATLEHAHQALEEEKKKTVDLLCSIFPS 459

  Fly   933 SVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKV 997
            .||.||..||.|.|:.|::||:.||||||||||.::.:|:||:..||.|||.||......|||||
  Rat   460 EVAQQLWQGQIVQAKKFNEVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGELDVYKV 524

  Fly   998 ETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVV 1062
            |||||||.|..||. |..:.||.:||.:||.::|..:.....|  .:.:|:|||||:|:..||||
  Rat   525 ETIGDAYCVAGGLH-RESDTHAVQIALMALKMMELSNEVMSPH--GEPIKMRIGLHSGSVFAGVV 586

  Fly  1063 GLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRR 1112
            |:|||||||||:.|..|::.||.....||::|.||...|.:...||.|.|
  Rat   587 GVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPR 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	3/14 (21%)
		Pkinase_Tyr	613..877	CDD:285015	3/8 (38%)
		HNOBA	<893..938	CDD:285003	16/44 (36%)
		CYCc	917..1108	CDD:214485	94/190 (49%)
		Guanylate_cyc	944..1130	CDD:278633	84/169 (50%)
Gucy1a1	NP_058786.2	HNOB	<111..234	CDD:285002
		HNOBA	276..465	CDD:285003	21/69 (30%)
		CYCc	444..633	CDD:214485	95/191 (50%)
		Guanylate_cyc	471..642	CDD:278633	84/169 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810