DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and NPR2

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	XP_024303324.1	Gene:	NPR2 / 4882	HGNCID:	7944	Length:	1103	Species:	Homo sapiens

Alignment Length:	1140	Identity:	481/1140 - (42%)
Similarity:	653/1140 - (57%)	Gaps:	143/1140 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    84 RQLVFVALLPSVESDNKNDCIMPKVLPVLELAIRHVQRMGFVGGSHFDIQLISRDT--FCSSKYG 146
            |.|....:||  |.:.......|:|.|.:.||:..:.|     ....|::.:|.:.  .||....
Human    23 RNLTLAVVLP--EHNLSYAWAWPRVGPAVALAVEALGR-----ALPVDLRFVSSELEGACSEYLA 80

  Fly   147 PIGFFEIYTQWPEVNAVFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKG 211
            |:...:: ..:.:.:.:.|..|.|..|.::|:|..|::|:||.|..|..|:.|::.|.||.| .|
Human    81 PLSAVDL-KLYHDPDLLLGPGCVYPAASVARFASHWRLPLLTAGAVASGFSAKNDHYRTLVR-TG 143

  Fly   212 AQVNNLGNVVRAILNSFNWT-RTALIYQNENAKVKGNSVCFLCLAAIHDTIE------EHSVYQL 269
            .....||..|..:...|||| |.||:|.:.....:.:   :..:..:.:.::      :|.||..
Human   144 PSAPKLGEFVVTLHGHFNWTARAALLYLDARTDDRPH---YFTIEGVFEALQGSNLSVQHQVYAR 205

  Fly   270 ---GFDTSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFS 331
               |.:.:|          ..:....|||.:|...:.:.:|:|.|:..| :.:|:|||..:::|.
Human   206 EPGGPEQAT----------HFIRANGRIVYICGPLEMLHEILLQAQREN-LTNGDYVFFYLDVFG 259

  Fly   332 R-----VQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNY 391
            .     ....|.:||.| |.|....:..::|:..:|.:|.::|.:.||....|.:...|.|.:..
Human   260 ESLRAGPTRATGRPWQD-NRTREQAQALREAFQTVLVITYREPPNPEYQEFQNRLLIRAREDFGV 323

  Fly   392 TFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTID 456
            ....: .::.....|:||:||||..|||:|:|..|.    .:|..:|.:|..|.:.|:||.|.:|
Human   324 ELGPS-LMNLIAGCFYDGILLYAEVLNETIQEGGTR----EDGLRIVEKMQGRRYHGVTGLVVMD 383

  Fly   457 ANGDRLSAYSLLDMNP-TTGRFEIVAHFLHNRLEFEANKEIHWAGDR----EEAPP-DRPICGY- 514
            .|.||.:.:.|..|.. .:|.|:..||:      ..|.|:|.|.|..    :.||| |.|.|.:
Human   384 KNNDRETDFVLWAMGDLDSGDFQPAAHY------SGAEKQIWWTGRPIPWVKGAPPSDNPPCAFD 442

  Fly   515 -DGALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHY---IAEAEINSMSWKVSLEDVMFRDA 575
             |...|....|...||:::..|...::..|..|..:|.|   :.|.|:.||.|::..|::.|.:
Human   443 LDDPSCDKTPLSTLAIVALGTGITFIMFGVSSFLIFRPYRKLMLEKELASMLWRIRWEELQFGN- 506

  Fly   576 AERGLRGSFHSLVKQSSQLTLMSE-----DMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGL 635
            :||..:|:       .|:|||...     .:::.:|..|||...|.|:.:.||||.|....::
Human   507 SERYHKGA-------GSRLTLSLRGSSYGSLMTAHGKYQIFANTGHFKGNVVAIKHVNKKRIE-- 562

  Fly   636 LTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLM 700
            |||.::.|||.|:|:|.:||.:|.|||:|.....::|||||:|||||||||:...||||||.||:
Human   563 LTRQVLFELKHMRDVQFNHLTRFIGACIDPPNICIVTEYCPRGSLQDILENDSINLDWMFRYSLI 627

  Fly   701 HDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLES------------ 753
            :|:|:||.|||:|.|.|||:||||||||||||||||||:||.:.|.|....:|
Human   628 NDLVKGMAFLHNSIISSHGSLKSSNCVVDSRFVLKITDYGLASFRSTAEPDDSHALYASEAHPHN 692

  Fly   754 -----------DG-----------------GNCNSHAYW------SKLLWTAPELLRVEHNRPPE 784
                       ||                 |.......|      |:.||||||||. .:..|..
Human   693 PLFILLLFPPRDGGRGRWSDSNIGMSPGGLGGAPFRGTWPAGFLFSEKLWTAPELLS-GNPLPTT 756

  Fly   785 GTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVK-GYNPHRMQKPFRPELEPNGDT 848
            |.||.|||:||||:.||..|.|||||.  ..:.||:||::.|: |..|:     |||.::
Human   757 GMQKADVYSFGIILQEIALRSGPFYLE--GLDLSPKEIVQKVRNGQRPY-----FRPSID----- 809

  Fly   849 KADING----IIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVE 909
            :..:|.    ::.||||:||||||||..:|..||||||:..| :|:||||.|||.||||||:|||
Human   810 RTQLNEELVLLMERCWAQDPAERPDFGQIKGFIRRFNKEGGT-SILDNLLLRMEQYANNLEKLVE 873

  Fly   910 ERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQV 974
            ||||.|.|||:|.|.||||:||.|||.||..|:.|.||.||.|||||||||||||:|||||||||
Human   874 ERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQV 938

  Fly   975 VQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIH 1039
            |..|||||||||:|::|||||||||||||||||||||.|||.:||.||||:|||||:||.:|||.
Human   939 VTLLNDLYTCFDAIIDNFDVYKVETIGDAYMVVSGLPGRNGQRHAPEIARMALALLDAVSSFRIR 1003

  Fly  1040 HRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEF 1104
            |||.|:|:||||:|||...||||||||||||||||||||||||||||:|||||:|.|||:||||.
Human  1004 HRPHDQLRLRIGVHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGQALKIHVSSTTKDALDEL 1068

  Fly  1105 GTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLI 1139
            |.|....||.|.|||||:|.||||.||...|..|:
Human  1069 GCFQLELRGDVEMKGKGKMRTYWLLGERKGPPGLL 1103

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	111/427 (26%)
		ANF_receptor	108..473	CDD:279440	100/382 (26%)
		PK_GC-A_B	589..883	CDD:270944	149/349 (43%)
		Pkinase_Tyr	613..877	CDD:285015	136/314 (43%)
		HNOBA	<893..938	CDD:285003	33/44 (75%)
		CYCc	917..1108	CDD:214485	149/190 (78%)
		Guanylate_cyc	944..1130	CDD:278633	146/185 (79%)
NPR2	XP_024303324.1	Periplasmic_Binding_Protein_Type_1	26..421	CDD:324556	111/429 (26%)
		PK_GC-A_B	521..848	CDD:270944	145/341 (43%)
		HNOBA	<857..902	CDD:311573	33/44 (75%)
		CYCc	881..1065	CDD:214485	144/183 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	295	1.000	Domainoid score	I1483
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H2970
Inparanoid	1	1.050	802	1.000	Inparanoid score	I503
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	1	1.000	-	-		FOG0002376
OrthoInspector	1	1.000	-	-		otm40865
orthoMCL	1	0.900	-	-		OOG6_100944
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5404
SonicParanoid	1	1.000	-	-		X2472
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.760