Protein Alignment CG31183 and NPR1

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: NP_000897.3
• Gene: NPR1 / 4881
• HGNCID: 7943
• Length: 1061
• Species: Homo sapiens
• Alignment Length: 1104
• Identity: 487/1104 - (44%)
• Similarity: 667/1104 - (60%)
• Gaps: 96/1104 - (8%)

  Fly    74 MPDHRR-LGARRQLVFVALLPSV-------ESDNKNDCIM------------PKVLPVLELAIRH 118
            ||..|| .|:|.:|:.:.|||.:       .:.|....::            .:|.|.:|||:..
Human     1 MPGPRRPAGSRLRLLLLLLLPPLLLLLRGSHAGNLTVAVVLPLANTSYPWSWARVGPAVELALAQ 65

  Fly   119 VQ-RMGFVGGSHFDIQLISRDT---FCSSKYGPIGFFEIYTQWPEVNAVF-GLPCEYVLAPISRY 178
            |: |...:.|......|.|.:.   .||....|:...::  :|....||| |..|.|..||:.|:
Human    66 VKARPDLLPGWTVRTVLGSSENALGVCSDTAAPLAAVDL--KWEHNPAVFLGPGCVYAAAPVGRF 128

  Fly   179 ADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAK 243
            ...|:||:||.|..|..|..|.| |:..|| .|.....||:.|.|:.....|.|.||:..   |.
Human   129 TAHWRVPLLTAGAPALGFGVKDE-YALTTR-AGPSYAKLGDFVAALHRRLGWERQALMLY---AY 188

  Fly   244 VKGNSV-CFLCLAAIHDTIEEHSVYQLGFDTSTWTKADI---TRMLKNVAMQSRIVIMCADPQSI 304
            ..|:.. ||..:..:...:.:.  ..:..|...:.:.|:   ||:|:.:..:.|::.:|:.|.:.
Human   189 RPGDEEHCFFLVEGLFMRVRDR--LNITVDHLEFAEDDLSHYTRLLRTMPRKGRVIYICSSPDAF 251

  Fly   305 RQIMLTAEELNMIDSGEYVFINIELFSRVQYLTS-------QPWYDKNDTDLNNERAQKAYTAML 362
            |.:||.|.|..:... :|||.::::|.  |.|..       :||...:..|::   |::|:.|..
Human   252 RTLMLLALEAGLCGE-DYVFFHLDIFG--QSLQGGQGPAPRRPWERGDGQDVS---ARQAFQAAK 310

  Fly   363 TVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTM 427
            .:|.|.|::.||.....::|.:|.|::|:|..|. .::....||.||:|||..|:.|::....|:
Human   311 IITYKDPDNPEYLEFLKQLKHLAYEQFNFTMEDG-LVNTIPASFHDGLLLYIQAVTETLAHGGTV 374

  Fly   428 LTRPINGTDMVRRMWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFEA 492
                .:|.::.:|||||||.|:||.:.||::|||.:.:||.||:|..|.|.:|.::.....|..|
Human   375 ----TDGENITQRMWNRSFQGVTGYLKIDSSGDRETDFSLWDMDPENGAFRVVLNYNGTSQELVA 435

  Fly   493 --NKEIHWAGDREEAPPDRPICGYDG--ALCPDNSLPGYAILSIVLGTMVVVMAVCFFFGYRHYI 553
              .::::|  .....|||.|.||:|.  ..|..:.|....:|::|....::.:.:..||.||...
Human   436 VSGRKLNW--PLGYPPPDIPKCGFDNEDPACNQDHLSTLEVLALVGSLSLLGILIVSFFIYRKMQ 498

  Fly   554 AEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSE-----DMVSINGDRQIFIP 613
            .|.|:.|..|:|..|||. ..:.||.||.:       .|:|||...     .:::..|..|:|..
Human   499 LEKELASELWRVRWEDVE-PSSLERHLRSA-------GSRLTLSGRGSNYGSLLTTEGQFQVFAK 555

  Fly   614 VGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKG 678
            ...::.:.||:|.|....::  |||.::.|||.|:|:|::||.:|.|||.|.....:||||||:|
Human   556 TAYYKGNLVAVKRVNRKRIE--LTRKVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRG 618

  Fly   679 SLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHT 743
            |||||||||...||||||.||.:|||:||.|||:..|.|||||||||||||.||||||||:||.:
Human   619 SLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLES 683

  Fly   744 LRRTRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPF 808
            .|    ||:.:.|    |..::|.|||||||||:. :.|..|:|.||||:||||:.||..|.|.|
Human   684 FR----DLDPEQG----HTVYAKKLWTAPELLRMA-SPPVRGSQAGDVYSFGIILQEIALRSGVF 739

  Fly   809 YLGRCAYEKSPQEIIELV-KGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNT 872
            ::.  ..:.||:||||.| :|..|     ||||.|......: ::..:::|||||||.|||.|..
Human   740 HVE--GLDLSPKEIIERVTRGEQP-----PFRPSLALQSHLE-ELGLLMQRCWAEDPQERPPFQQ 796

  Fly   873 LKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQ 937
            ::..:|:||::| :.||:||||.|||.||||||||||||||.|.|||:|.|.||||:||.|||.|
Human   797 IRLTLRKFNREN-SSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQ 860

  Fly   938 LISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGD 1002
            |..|:.|.||.||.|||||||||||||:||||||||||..|||||||||::::||||||||||||
Human   861 LKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGD 925

  Fly  1003 AYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMP 1067
            |||||||||:|||..||.|:||:|||||:||.:|||.|||:::|:||||:|||...|||||||||
Human   926 AYMVVSGLPVRNGRLHACEVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMP 990

  Fly  1068 RYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE 1131
            |||||||||||||||||||||||||:|..||..|:|||.|....||.|.|||||::.||||.||
Human   991 RYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGE 1054

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596	125/442 (28%)
		PK_GC-A_B	589..883	CDD:270944	142/299 (47%)
		HNOBA	<890..938	CDD:462234	36/47 (77%)
		CYCc	917..1108	CDD:214485	145/190 (76%)
NPR1	NP_000897.3	PBP1_NPR_A	36..443	CDD:380608	121/426 (28%)
		PK_GC-A_B	534..807	CDD:270944	138/291 (47%)
		HNOBA	<813..861	CDD:462234	36/47 (77%)
		CYCc	840..1032	CDD:214485	146/191 (76%)