DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and Gycbeta100B

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_524603.2	Gene:	Gycbeta100B / 43682	FlyBaseID:	FBgn0013973	Length:	787	Species:	Drosophila melanogaster

Alignment Length:	753	Identity:	189/753 - (25%)
Similarity:	289/753 - (38%)	Gaps:	227/753 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   632 VQGLLTRSLMLELKRMKDLQHDHLVKFYGA-------CLDQRRSFLLTEYCPKGSLQDI------ 683
            |.|...|..:..|    |..||||...|..       |.::....||..|..:..|:.|
  Fly    89 VLGATPRDFLQNL----DALHDHLGTLYPGMRAPSFRCTEKDGELLLHYYSERPGLEHIVIGIVK 149

  Fly   684 -----LENEQFQLDWMFR------------------LSLMHDIV--------------------- 704
                 |...:.::|.:.|                  ..|:.|.|
  Fly   150 AVASKLHGVEVEIDIVKRKGEPIDEAEKERAIARENQQLLEDAVATTTTGSATVVLAPSSDAERN 214

  Fly   705 ---RGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITD--FGLHT--LRRTRFDLESDGGNCNSHA 762
               .|....:::.:.::||..:.|...|.:.:...||  ..|.|  :.:..||.:.|
  Fly   215 NNHNGSNGSNNNGMANNGNTVNVNNNNDGQQIASETDPSIALSTCPIAQDSFDCDGD-------- 271

  Fly   763 YWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITT------------------------ 803
                   ...:.||:..|: .:..::.|...|  ::.||..
  Fly   272 -------KEQKCLRLLKNK-SDDIERYDHVQF--LIREINVAAKSQVDAKKDEVPDDMEFLCEAP 326

  Fly   804 --------RQGPFYL-----------GRCAYEKSPQ------EIIELVKGYNPHRMQKPFRPELE 843
                    :..||:|           |:......|:      .:||:|:...|| :|..|...|
  Fly   327 LISPATFCKVFPFHLMFDRQMKIVQAGKAVSRVIPRVAEENCSLIEVVEAIRPH-LQLNFENIL- 389

  Fly   844 PNGDTKADINGII---RRCWAEDPAERPDFNTLKSMIRRFNKDNETGNI----------VDNLLK 895
                  :.||.|.   .|..|........|..||..:...   .||..|          :|:|.|
  Fly   390 ------SHINTIYVLQTRQGAMSSRHEQRFLRLKGQMMYI---PETDRILFQCYPSVMNLDDLTK 445

  Fly   896 RMELY--------------------------ANNLEELVEERTQ---DYHEEKKKCEKLLYQLLP 931
            : .||                          ..|||.|.::..|   |...||:|.::|||.:||
  Fly   446 K-GLYISDVPLHDAARDLVLLSEKFEAEYKLTKNLEMLTDKLQQTFRDLESEKQKTDRLLYSVLP 509

  Fly   932 QSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAEST----PMQVVQFLNDLYTCFDSIVE-- 990
            :|||.:|...:||..:.:|.||:.||.||||....|.:|    .|::|:.||:|||.||::.:
  Fly   510 KSVANELRHQRPVPPKRYDSVTLMFSGIVGFGQYCAANTDPDGAMKIVKMLNELYTVFDALTDSK 574

  Fly   991 -NFDVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHT 1054
             |.:||||||:||.||.||||| .:...||:.:||:||.:::...|.::...|   :::.||:|:
  Fly   575 RNLNVYKVETVGDKYMAVSGLP-DHCEDHAKCMARVALDMMDMAKNVKMGSNP---VQITIGIHS 635

  Fly  1055 GACVAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKE----ALDEFGTFVTTRRGFV 1115
            |..|.||:|.::|||||||:|||..||.|:.|...:|::||.|..    |:::..:|....||.|
  Fly   636 GEVVTGVIGNRVPRYCLFGNTVNLTSRTETTGVPGRINVSEETYRLLCMAINQDDSFHLEYRGPV 700

  Fly  1116 PMKGKGEMLTYWLEGEVPRPNSLISPSKLMLTRRSSLKQPQRSQSHNLHKQYSELVVASP--PPQ 1178
            .||||...:..|.         |...:..:|...||........:.:|.         ||  .|.
  Fly   701 IMKGKPTPMDCWF---------LTRATSSILGGTSSTGGSGGGGNGSLD---------SPLLQPA 747

  Fly  1179 LPPPAIALPPPPSPSKDSPNLRVKRKISSSSPKLNGGG 1216
            .|....|.|.|....:.:.:..|.|   :||....|||
  Fly   748 TPTAGAATPIPVVAQRAAGHASVSR---TSSAGGGGGG 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	62/366 (17%)
		Pkinase_Tyr	613..877	CDD:285015	62/360 (17%)
		HNOBA	<893..938	CDD:285003	21/73 (29%)
		CYCc	917..1108	CDD:214485	85/201 (42%)
		Guanylate_cyc	944..1130	CDD:278633	81/196 (41%)
Gycbeta100B	NP_524603.2	HNOB	2..164	CDD:285002	17/78 (22%)
		HNOBA	326..516	CDD:285003	46/201 (23%)
		CYCc	496..688	CDD:214485	85/195 (44%)
		Guanylate_cyc	522..714	CDD:278633	81/204 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45453968
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740