DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and Gyc89Da

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster

Alignment Length:	711	Identity:	180/711 - (25%)
Similarity:	292/711 - (41%)	Gaps:	189/711 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   520 PDNSLPGYA-ILSIVLGT----MVVVMAVCFF-----FGYRHYIAEAEINSMSWKVSLEDVMFRD 574
            ||..:|..| .||...|.    .:.....||.     |||...|.........:..|::::...
  Fly    43 PDKLMPDIAEALSACTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLI- 106

  Fly   575 AAERGLRGSFHSLVKQSSQLTLMSEDMVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRS 639
                 :|.::..:...|.|||.|.:     ||      .|.::|.|:..:....:..:..:....
  Fly   107 -----MRFTYPKMKSPSMQLTNMDD-----NG------AVILYRSSRTGMSKYLIGQMTEVAREF 155

  Fly   640 LMLELK------------------RMKDLQHDHLVKFYGACLD-QRRSFLL----TEYCPKGSLQ 681
            ..||:|                  ::.|.....:||:.   || ..|.::.    ||..|.....
  Fly   156 YGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIVKYR---LDFDNREYMAKRVNTEAHPSQLKM 217

  Fly   682 DILENEQFQLDWMFRLSLMHDIVRGMQFLHSSD-------IRSHG-NLKSSNCVVDSRFVLKITD 738
            ..::.:.|...:.|...|.||    |:..|:.:       :.:.| |.||        |:
  Fly   218 PTVKLDVFLDLFPFTFVLNHD----MKITHAGEKIVETWIMHNPGANPKS--------FI----- 265

  Fly   739 FGLHTL-----RRTRFDLESDGGNCNSHAYWSKLLWTAP-----ELLRVEHNRPPEGTQKGDVYA 793
             |.|.:     ||.: |...|         |..|:....     ||:|..|||.          |
  Fly   266 -GTHVMDLFQCRRPK-DTTID---------WDTLIQMRAVLFEFELIRTGHNRA----------A 309

  Fly   794 FGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRR 858
            :..:::..........|...       :.:.|.|.       :.|......:.|..|..:.|
  Fly   310 YDAVLNMDFENYDEMDLNEA-------QTMALAKA-------QEFSESHPVDDDESAREDEI--- 357

  Fly   859 CWAEDPA--ERPDFNTLKSMIRR----FNKDNET-----GNIVDNL--LKRMELYANNL------ 904
                |||  ||.....|:|::.:    :.||.::     ..:::||  |..:.||.|:|
  Fly   358 ----DPATGERRSSQGLRSILLKGQMFYIKDVDSLIFLCSPLIENLDELHGIGLYLNDLNPHGLS 418

  Fly   905 EELV----------------EERTQDYHEE--------KKKCEKLLYQLLPQSVAAQLISGQPVV 945
            .|||                ||:..|..|:        |::.::|||.::|:.:|.::...:..|
  Fly   419 RELVMAGWQHCSKLEIMFEKEEQRSDELEKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQV 483

  Fly   946 AETFDQVTIYFSDIV-----GFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYM 1005
            .::|::|::.|.:::     |..:|..   .||.|..||.:::..|..:.:..||||||:|..||
  Fly   484 CQSFEEVSVIFLEVMNVYDEGLNSIQG---AMQTVNTLNKVFSALDEEIISPFVYKVETVGMVYM 545

  Fly  1006 VVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYC 1070
            .|||.|..| ..||.....|||.:::   .|:.|...:  :.:|:|:::|..||||||.|:||||
  Fly   546 AVSGAPDVN-PLHAEHACDLALRVMK---KFKAHDMGD--VAIRVGINSGPVVAGVVGQKVPRYC 604

  Fly  1071 LFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYW-LEG 1130
            ||||||||||||||:.:..||.:|:.|.:.:.:.| :....||.|.:||||:|.||| |||
  Fly   605 LFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQVG-YKVESRGTVQVKGKGDMETYWLLEG 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	63/340 (19%)
		Pkinase_Tyr	613..877	CDD:285015	56/306 (18%)
		HNOBA	<893..938	CDD:285003	19/76 (25%)
		CYCc	917..1108	CDD:214485	73/203 (36%)
		Guanylate_cyc	944..1130	CDD:278633	78/191 (41%)
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	27/134 (20%)
		HNOBA	218..476	CDD:285003	63/316 (20%)
		CYCc	457..643	CDD:214485	72/195 (37%)
		Guanylate_cyc	485..662	CDD:278633	76/186 (41%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454051
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740