DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG31183 and Ac76E

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster

Alignment Length:	530	Identity:	134/530 - (25%)
Similarity:	202/530 - (38%)	Gaps:	118/530 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   899 LYANNLEELVEERTQD-----------YHEEKKKCEKLLYQLLPQSVAA--------------QL 938
            ||...:.:....||.|           ...|:::.|:||..::|..:||              |.
  Fly   229 LYYRIMSDAAHNRTVDGTRTGIEQRVKLECEREQQEQLLLSVIPAYIAAEVKRSIMLKMADACQR 293

  Fly   939 ISGQPVVAET---------FDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDV 994
            ..||...:.|         ...|||.|:|||.||.:|:..|...:|:.||||:..||.|.:....
  Fly   294 AGGQASTSATRFHELHVQRHTNVTILFADIVNFTPLSSSLTASDLVKTLNDLFGRFDQIAQENQC 358

  Fly   995 YKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVA 1059
            .:::.:||.|..|||||| :..|||.....:.|.:::|:.:.|  ......:.:|||:|||..:.
  Fly   359 LRIKILGDCYYCVSGLPI-SRPQHATNCVNMGLQMIDAIRHVR--EATGINVDMRIGIHTGNVLC 420

  Fly  1060 GVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRG----------- 1113
            ||:||:..::.::.|.|..|:.|||.|.|.::||   ||:.||..|......:|
  Fly   421 GVLGLRKWQFDVWSDDVTLANHMESGGVAGRVHI---TKQTLDFLGDKFEVEQGEGGNRDAYLAD 482

  Fly  1114 -------FVPMKGKGEMLTYWLEGEVPRPNSLISPSKLMLTRRSSLKQPQRSQSHNLHKQYSELV 1171
                   .||.|   ...||    .|||....|..:....|...:.:..:..|||........|:
  Fly   483 HKVESYLIVPPK---PAYTY----SVPRVVECIEQNDPSPTTEETKEIKETDQSHEATDVADVLL 540

  Fly  1172 VASPPPQLPPPAIALPPPPSPSKDSPNLRVKRKISSSSPKLNGGGFDYHKTENHYLDTAAAAQRN 1236
               |....|||||.      ..|.||.     .|:|....|             :...|:||
  Fly   541 ---PVTVAPPPAIV------DEKMSPT-----SINSQEAPL-------------HAPLASAA--- 575

  Fly  1237 CDIYSSRSLRDM-EETSDSWELAHFRLPLSGALKSHHHLNNNSHGYVHSNSSSNLSGILQPPPLG 1300
                 |.|:::: ||..::.|......||     .|...:..:.....:|.....||
  Fly   576 -----SMSIKELSEEEDEADEATAVTEPL-----MHRDQDGKNDKEPKANGGHRGSG-------- 622

  Fly  1301 VQRTRLKPSPTISTLLTSARSEANASPGPETGSMGSGQLRIKFAEGDETPLLPTPPPLAAPPPIP 1365
              .:....|...|..|:....:..:..|.|:|...||...........||....|...||...:
  Fly   623 --DSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQAQSSNPASVTPTAAAPAGGAASNSL- 684

  Fly  1366 QMVAASPQRS 1375
             .||.:|:||
  Fly   685 -TVAEAPERS 693

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944
		Pkinase_Tyr	613..877	CDD:285015
		HNOBA	<893..938	CDD:285003	12/63 (19%)
		CYCc	917..1108	CDD:214485	70/213 (33%)
		Guanylate_cyc	944..1130	CDD:278633	66/212 (31%)
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	12/59 (20%)
		CYCc	259..467	CDD:214485	70/213 (33%)
		Guanylate_cyc	311..469	CDD:278633	59/163 (36%)
		BASP1	510..667	CDD:283191	39/206 (19%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454060
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740