DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and ACXC

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster

Alignment Length:	1186	Identity:	235/1186 - (19%)
Similarity:	403/1186 - (33%)	Gaps:	388/1186 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   192 NAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSVCFLCLAA 256
            ||..||......||:..|....:    |.....::...|...|            :||..:.|..
  Fly    87 NAVFFNFVIRVVSTILVLTVLSI----NFCEKFVSRHRWVMIA------------SSVLSVYLVV 135

  Fly   257 IHDTIEEHSVYQLGFDTSTW---TKADITRMLKNVAMQSRIVIMCADPQSIRQIMLTAEELNMID 318
            :.|.:    :....|..:.|   |..|:..:.        ::.|.....||:...|.|..:::|
  Fly   136 LTDIV----MISYHFYKNDWPLNTSFDVFTLC--------MIYMFLPIPSIKGAALLASSVSLI- 187

  Fly   319 SGEYV--FINIELFSRVQYLTSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNE- 380
               ||  |::...|:.|........||...||:.:.....    |:.:         :.|:.|:
  Fly   188 ---YVAFFMHSLTFNAVYTDRDSFGYDVISTDILHNLGFN----MMGI---------FFRIMNDT 236

  Fly   381 -IKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALNESIREDPTMLTRPI------------ 432
             ::|...:::.:...:         ::....||..:.|.:||.  |..:.:|:
  Fly   237 MVRASFLDRHQFIMEE---------TWLRHALLQESILLDSIL--PPQIAKPVQEKIKSKITQSE 290

  Fly   433 NGTDMVRR--MWNRSFTGITGNVTIDANGDRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFEAN-- 493
            |..|..:.  ....||..|..:..:......:..|:.|....|.|....|.|.|:.|.:..|:
  Fly   291 NSPDRFQMGPRTTESFMAIQIHPDVSILYADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNF 355

  Fly   494 --KEIHWAGDREEAPPDRPICGY--DGALCPDNSLPGYAILSIVLGTMVVV-------------- 540
              :.|.:.||          |.|  .|...||   |.:|...:.||..::.
  Fly   356 KVQRIKFLGD----------CYYCVAGLTTPD---PDHAKCCVSLGISMISNIQEVRAERGLDID 407

  Fly   541 MAVCFFFG--YRHYIAEAEINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQL-----TLMS 598
            |.:....|  ....|.||::....|...:|  :.......|..|..|...:..|.|     |::|
  Fly   408 MRIGVHSGSLLAGIIGEAKLQFDIWGTDVE--IANHLESTGEPGYVHVSGRTLSMLNPADYTILS 470

  Fly   599 ------EDMV-------SINGD--RQIFI-PVGMFRKSKVAIKPVEVDNVQGLLTRSLMLELKRM 647
                  .|.|       .:.|.  |:.|| .:|..|.|.|    :||.::..:  ||.......|
  Fly   471 GTQKAQSDPVLQYIHTYLLTGQVARESFITSIGGVRSSSV----LEVKSIDRI--RSSRPSQSSM 529

  Fly   648 KDLQHDHL-------VKFYGACLDQRRSFLLTE---------YCPKGSLQDILENEQFQLDWMFR 696
            .|...:..       :.....|.  ||:.|.|.         :|.......:..|...|.|::|:
  Fly   530 TDEFREEFRNMPVGGINLNSPCC--RRTRLDTHKKTQREIGIFCAAFKDSSLEWNYLHQPDFIFK 592

  Fly   697 LSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSH 761
            .|::.....|...::...:.:  |...:.|:|    |..:|.|.|.:|.            |  .
  Fly   593 SSMLLAWGIGCCLIYIQIVTN--NFSCTACIV----VDLVTFFFLTSLL------------C--L 637

  Fly   762 AYWSKLLWTAPELLRVEHNRPPEGTQKGDVY------AFGI---IVHEITTRQGPFYLG------ 811
            |::..:.|.            ..|..:..:|      ||.|   |.|.::.|. ..|||
  Fly   638 AWYKNVCWW------------KSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRI-TVYLGILFSYY 689

  Fly   812 -----------RCAYEKSPQE---------------------IIELVKGYNPHRMQKPFRPEL-- 842
                       |..||.|..|                     :|.|:.|.:....:.||..::
  Fly   690 AVISLIMLNCDRDMYELSYIESKIYHYEMDRDTCFHPWVFTNMISLILGISYTFARIPFGLKIVI 754

  Fly   843 --------------------EPNGDT----KADINGIIRRC------WAEDPAERPDFNTLKSMI 877
                                :.:..|    ||::...:|.|      :|::  .:.:|||  .|.
  Fly   755 SCCETLAYLLIVFFQFAFIFQHSATTTPFMKAELAHCLRVCMMLLTMYAKE--RQSEFNT--KMN 815

  Fly   878 RRFNKDNETGN------------IVDNLLKR--MELYANNLEELVEERTQDYHEEKKKCEKLLYQ 928
            .:.|.|.:...            :::|:|..  ::||.|:|.:         ||        ||.
  Fly   816 YKLNVDLQNKQKAADLTNQSIIILLNNILPSHVVDLYLNSLAK---------HE--------LYY 863

  Fly   929 LLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQV--VQFLNDLYTCFDSIV-- 989
                              |.:..|::.|:.::.|        ||.:  ::.|||:.|.||.::
  Fly   864 ------------------ENYRMVSVMFAMLINF--------PMNLPSLRVLNDIITQFDRLLTA 902

  Fly   990 --ENFDVYKVETIGDAYMVVSGLP------------IRNGN-----QHARE-------------- 1021
              |.:.|.|::.:|..||...||.            .||.:     :|||.
  Fly   903 YREYYVVEKIKVVGCTYMAACGLDFNLASNIRQTDHFRNSSLHVEVEHARNHRMTDENYDSDMNN 967

  Fly  1022 ------IARLALALLEAV------HNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGD 1074
                  :...||.|:..:      ::.....|...:.|:.||:.:|..:|||||...|.|.::|:
  Fly   968 DEVVFIMTTFALDLMRTLAACNRAYSSSFFERSLSQGKICIGISSGEIMAGVVGASQPHYDIWGN 1032

  Fly  1075 TVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLI 1139
            .||.||||||.|....|.::|.:.:.|.|| ......||...:||:|::.||::..:   .|...
  Fly  1033 PVNMASRMESTGLPGHIQVTEESAKILQEF-DIKCIYRGMTFVKGRGDIPTYFVGID---ENLKF 1093

  Fly  1140 SPSKLM---LTRRSSL 1152
            ..:||:   |:||.|:
  Fly  1094 MSAKLVNRSLSRRFSV 1109

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	59/330 (18%)
		ANF_receptor	108..473	CDD:279440	51/301 (17%)
		PK_GC-A_B	589..883	CDD:270944	75/409 (18%)
		Pkinase_Tyr	613..877	CDD:285015	63/358 (18%)
		HNOBA	<893..938	CDD:285003	9/46 (20%)
		CYCc	917..1108	CDD:214485	58/239 (24%)
		Guanylate_cyc	944..1130	CDD:278633	62/234 (26%)
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	44/253 (17%)
		CYCc	293..468	CDD:214485	37/189 (20%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	34/173 (20%)
		CYCc	833..1060	CDD:214485	62/269 (23%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	64/250 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454012
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.740