Protein Alignment CG31183 and GUCY2D

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: NP_000171.1
• Gene: GUCY2D / 3000
• HGNCID: 4689
• Length: 1103
• Species: Homo sapiens
• Alignment Length: 1193
• Identity: 372/1193 - (31%)
• Similarity: 574/1193 - (48%)
• Gaps: 218/1193 - (18%)

  Fly    70 PSLP-MPDHRRLGARRQLVFVALL---PSVES--------DNKNDCIMPKVLPVL--ELAIRHVQ 120
            |||| :|   |...|..|:.:.||   |::.:        ....|.|..:..|.|  .||...:.
Human    24 PSLPRLP---RALPRLPLLLLLLLLQPPALSAVFTVGVLGPWACDPIFSRARPDLAARLAAARLN 85

  Fly   121 R-MGFVGGSHFDIQLISRDTFCSSKYGPIGFFEIYTQWPEVNAVFG-------LPCEYVLAPISR 177
            | .|..||..|::.|:...  |.:. |.:|  .:.:....|:.:.|       .|.| :||..:.
Human    86 RDPGLAGGPRFEVALLPEP--CRTP-GSLG--AVSSALARVSGLVGPVNPAACRPAE-LLAEEAG 144

  Fly   178 YADV-WQVPVLTTGGNAKEFNKKSESYSTLTRLKGAQVNNLGNVVRAILNSFNWTRTALIYQNEN 241
            .|.| |..|.....|..                 ...|....:.:.|:|.:|.|.|.||:...::
Human   145 IALVPWGCPWTQAEGTT-----------------APAVTPAADALYALLRAFGWARVALVTAPQD 192

  Fly   242 AKVKGNSVCFLCLAAIHDTIEEHSVYQLGFDTSTWTK---------ADITRMLKN------VAMQ 291
            ..|:........|.|            .|...::.|.         .:..|.:::      |.|.
Human   193 LWVEAGRSLSTALRA------------RGLPVASVTSMEPLDLSGAREALRKVRDGPRVTAVIMV 245

  Fly   292 SRIVIMCADPQSIRQIMLTAEELNMIDSGEYVFINIELFSRVQYLTSQPWYDKNDTDLNNERAQK 356
            ...|::..:.|  |.::..||||.:.| |..||:.   |..:.|..| |..:......|:.:.::
Human   246 MHSVLLGGEEQ--RYLLEAAEELGLTD-GSLVFLP---FDTIHYALS-PGPEALAALANSSQLRR 303

  Fly   357 AYTAMLTVTPKQPNDN---EYTRVSNEIKAIAAEKYNYTFSDNEPISAFVTSFFDGVLLYANALN 418
            |:.|:||:|...|::.   :..|.:.|.:.:.::      .:.:.:|....:.:|.|.|.|..:.
Human   304 AHDAVLTLTRHCPSEGSVLDSLRRAQERRELPSD------LNLQQVSPLFGTIYDAVFLLARGVA 362

  Fly   419 ESIREDPTMLTRPINGTDMVRRMWNRSFTGITGN-----------VTIDANGDRLSAYSLLDMNP 472
            |:   ......|.::|..:.|.:.:....|..|:           :..||.||||.|..:||  |
Human   363 EA---RAAAGGRWVSGAAVARHIRDAQVPGFCGDLGGDEEPPFVLLDTDAAGDRLFATYMLD--P 422

  Fly   473 TTGRFEIVAHFLHNRLEFEANKEIHWAGDREEAPPDRPICGYD-GALCPDNSLPGYAILSIVLGT 536
            ..|.|            ..|...:|:........|| |.|.:| ..:|.....||.    :.||.
Human   423 ARGSF------------LSAGTRMHFPRGGSAPGPD-PSCWFDPNNICGGGLEPGL----VFLGF 470

  Fly   537 MVVV---MAVCFFFGY-RHYIAEAEINSMSWKV--SLEDVMFRDAAERGLRGSFHSLVKQSSQLT 595
            ::||   :|..|...| ||.:...::.|...|:  :::|:.|...     .|.....|.|.|:.:
Human   471 LLVVGMGLAGAFLAHYVRHRLLHMQMVSGPNKIILTVDDITFLHP-----HGGTSRKVAQGSRSS 530

  Fly   596 LMSEDMVSING--DRQIFIP-VGMFRKSKVAIKPVEVDNVQGLLTR-SLMLELKRMKDLQHDHLV 656
            |.:..|..|..  .:.:..| :|::...:|.:|....|  |.:..| :......::::|:|:::.
Human   531 LGARSMSDIRSGPSQHLDSPNIGVYEGDRVWLKKFPGD--QHIAIRPATKTAFSKLQELRHENVA 593

  Fly   657 KFYG----------ACLDQRRSFLLTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLH 711
            .:.|          |.|.:....:::|:|.:|||||:|...:.:|||||:.||:.|:::|:::||
Human   594 LYLGLFLARGAEGPAALWEGNLAVVSEHCTRGSLQDLLAQREIKLDWMFKSSLLLDLIKGIRYLH 658

  Fly   712 SSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKL--------- 767
            ...: :||.|||.||:||.||||||||.|...|      ||:           .|:
Human   659 HRGV-AHGRLKSRNCIVDGRFVLKITDHGHGRL------LEA-----------QKVLPEPPRAED 705

  Fly   768 -LWTAPELLR---VEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKG 828
             |||||||||   :|.    .||..|||::..||:.|:..|..|:.:    .|.:|:|:::.|:
Human   706 QLWTAPELLRDPALER----RGTLAGDVFSLAIIMQEVVCRSAPYAM----LELTPEEVVQRVR- 761

  Fly   829 YNPHRMQKPFRPELEPNGDTKADINGIIRRCWAEDPAERPDFNTLKSMIRRFNKDNETGNIVDNL 893
             :|..:.:|    |........:...::::||||.|..||..:....:.:..||..:| ||:|::
Human   762 -SPPPLCRP----LVSMDQAPVECILLMKQCWAEQPELRPSMDHTFDLFKNINKGRKT-NIIDSM 820

  Fly   894 LKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSD 958
            |:.:|.|::|||:|:.|||::...||:|.::||.|:||.|||..|.:|.||..|.|:|||:||||
Human   821 LRMLEQYSSNLEDLIRERTEELELEKQKTDRLLTQMLPPSVAEALKTGTPVEPEYFEQVTLYFSD 885

  Fly   959 IVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREIA 1023
            |||||.|||.|.|::||..||||||.||:|:.:.||||||||||||||.||||.|||.:||.|||
Human   886 IVGFTTISAMSEPIEVVDLLNDLYTLFDAIIGSHDVYKVETIGDAYMVASGLPQRNGQRHAAEIA 950

  Fly  1024 RLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGEA 1088
            .::|.:|.||..||:.|.||..:::|||||:|.||||||||.|||||||||||||||||||.|..
Human   951 NMSLDILSAVGTFRMRHMPEVPVRIRIGLHSGPCVAGVVGLTMPRYCLFGDTVNTASRMESTGLP 1015

  Fly  1089 LKIHISETT---KEALDEFGTFVTTRRGFVPMKGKGEMLTYWLEGE------VPRPNSL------ 1138
            .:||::.:|   ..|||  ..:....||...:||||...|:||.|.      :|:|..|
Human  1016 YRIHVNLSTVGILRALD--SGYQVELRGRTELKGKGAEDTFWLVGRRGFNKPIPKPPDLQPGSSN 1078

  Fly  1139 --ISPSKLMLTRRSSLKQPQRSQ 1159
              ||..::...||..|::.:..|
Human  1079 HGISLQEIPPERRRKLEKARPGQ 1101

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596	92/456 (20%)
		PK_GC-A_B	589..883	CDD:270944	93/320 (29%)
		HNOBA	<890..938	CDD:462234	22/47 (47%)
		CYCc	917..1108	CDD:214485	120/193 (62%)
GUCY2D	NP_000171.1	PBP1_sensory_GC_DEF-like	55..431	CDD:380594	89/440 (20%)
		PK_GC-2D	536..811	CDD:270945	90/308 (29%)
		HNOBA	<820..865	CDD:462234	21/44 (48%)
		CYCc	846..1036	CDD:214485	119/191 (62%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1065..1103		9/37 (24%)