DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and GUCY2C

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_004954.2	Gene:	GUCY2C / 2984	HGNCID:	4688	Length:	1073	Species:	Homo sapiens

Alignment Length:	1128	Identity:	361/1128 - (32%)
Similarity:	538/1128 - (47%)	Gaps:	237/1128 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 NKNDCIMPKVLPVLEL--AIRHVQRMGFVGGSHFDIQLISRDTFCSSKYGPIGFFEIY----TQW 157
            |..|| .......|:|  .|.:.||||.|        ||......|:       |::|    ..:
Human    91 NSGDC-RSSTCEGLDLLRKISNAQRMGCV--------LIGPSCTYST-------FQMYLDTELSY 139

  Fly   158 PEVNA-VFGLPCEYVLAPISRYADVWQVPVLTTGGNAKEFNKKSESYSTLTRLKGA--------- 212
            |.::| .|||.|:|                       ||         |||||...
Human   140 PMISAGSFGLSCDY-----------------------KE---------TLTRLMSPARKLMYFLV 172

  Fly   213 ---QVNNLGNVVRAILNSFNWTRTALIYQNENAKVKGNSV--CFLCLAAIHDTIEEHSVYQLGFD 272
               :.|:|.      ..:::|: |:.:|:|      |...  ||..|.|:..::...| ::|||.
Human   173 NFWKTNDLP------FKTYSWS-TSYVYKN------GTETEDCFWYLNALEASVSYFS-HELGFK 223

  Fly   273 TSTWTKADITRMLKNVAMQSRIVIMCADPQSIRQI---MLTAEELNMIDSGEYVFINIELFSRVQ 334
            .......:...:|.:...:|.::|||..|:.:.::   ...||::        |.|.::||:. |
Human   224 VVLRQDKEFQDILMDHNRKSNVIIMCGGPEFLYKLKGDRAVAEDI--------VIILVDLFND-Q 279

  Fly   335 YL---TSQPWYDKNDTDLNNERAQKAYTAMLTVTPKQPNDNEYTRVSNEIKAIAAEKYNYTFSDN 396
            |.   .:.|.|.||             ..:||::|           .|.:       .|.:||.|
Human   280 YFEDNVTAPDYMKN-------------VLVLTLSP-----------GNSL-------LNSSFSRN 313

  Fly   397 -EPISA-FVTSFFDGVLLYANALNESIREDPTMLTRPINGTDMVRRMWNRSFTGITGNVTIDANG 459
             .|... |..::.:|:||:.:.| :...|:...:|.|    .......|.:|.|..|.||:|..|
Human   314 LSPTKRDFALAYLNGILLFGHML-KIFLENGENITTP----KFAHAFRNLTFEGYDGPVTLDDWG 373

  Fly   460 DRLSAYSLLDMNPTTGRFEIVAHFLHNRLEFEANKEIHWAGDREEAPPD-RPICGYDGALCPDNS 523
            |..|...||..:..|.:::::..:     :...||..         |.| .|...:..:..| |.
Human   374 DVDSTMVLLYTSVDTKKYKVLLTY-----DTHVNKTY---------PVDMSPTFTWKNSKLP-ND 423

  Fly   524 LPGYA--ILSIVLGTM---VVVMAVCFFFGYRHYIAEAEINSMSWK-VSLEDVMFRDAAERGLRG 582
            :.|..  ||.|.:.|:   ||::.:......|.|..:.|:....|. :..|::
Human   424 ITGRGPQILMIAVFTLTGAVVLLLLVALLMLRKYRKDYELRQKKWSHIPPENI------------ 476

  Fly   583 SFHSLVKQSSQLTLMSED---MVSINGDRQIFIPVGMFRKSKVAIKPVEVDNVQGLLTRSLMLEL 644
             |.....:::.::|..:|   ..:|...||.     .:.|.:|.:|  ::.:..|..|....:||
Human   477 -FPLETNETNHVSLKIDDDKRRDTIQRLRQC-----KYDKKRVILK--DLKHNDGNFTEKQKIEL 533

  Fly   645 KRMKDLQHDHLVKFYGACLDQRRSFLLTEYCPKGSLQDILENEQFQ------LDWMFRLSLMHDI 703
            .::..:.:.:|.||||........|.:.|||.:|||:::| |:...      :||.|::|:::||
Human   534 NKLLQIDYYNLTKFYGTVKLDTMIFGVIEYCERGSLREVL-NDTISYPDGTFMDWEFKISVLYDI 597

  Fly   704 VRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLL 768
            .:||.:||||....||.|||:|||||||.|:||||||                 |||.....|.|
Human   598 AKGMSYLHSSKTEVHGRLKSTNCVVDSRMVVKITDFG-----------------CNSILPPKKDL 645

  Fly   769 WTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPFYLGRCAYEKSPQEIIELVKGYNPHR 833
            ||||     ||.|....:||||||::|||..||..|:..||...|   :...|.|..|:..|.
Human   646 WTAP-----EHLRQANISQKGDVYSYGIIAQEIILRKETFYTLSC---RDRNEKIFRVENSNG-- 700

  Fly   834 MQKPFRPE--LEPNGDTKADINGIIRRCWAEDPAERPDF----NTLKSMIRRFNKDNETGNIVDN 892
             .|||||:  ||...:.:.::..:::.||.|||.:||||    .||..:...|: |.:..:.:|.
Human   701 -MKPFRPDLFLETAEEKELEVYLLVKNCWEEDPEKRPDFKKIETTLAKIFGLFH-DQKNESYMDT 763

  Fly   893 LLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISGQPVVAETFDQVTIYFS 957
            |::|::||:.|||.|||||||.|..|:.:.::|.:.|||:.|...|.....|..|.:::||||||
Human   764 LIRRLQLYSRNLEHLVEERTQLYKAERDRADRLNFMLLPRLVVKSLKEKGFVEPELYEEVTIYFS 828

  Fly   958 DIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENFDVYKVETIGDAYMVVSGLPIRNGNQHAREI 1022
            ||||||.|...||||:||..|||:|..||.||::.||||||||||||||.||||.||||:||.:|
Human   829 DIVGFTTICKYSTPMEVVDMLNDIYKSFDHIVDHHDVYKVETIGDAYMVASGLPKRNGNRHAIDI 893

  Fly  1023 ARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESNGE 1087
            |::||.:|..:..|.:.|.|...:.:|||:|:|.|.|||||:||||||||||||||||||||.|.
Human   894 AKMALEILSFMGTFELEHLPGLPIWIRIGVHSGPCAAGVVGIKMPRYCLFGDTVNTASRMESTGL 958

  Fly  1088 ALKIHISETTKEALDEFG-TFVTTRRGFVPMKGKGEMLTYWLEGEVPRPNSLISPSKLMLTRRSS 1151
            .|:||:|.:|...|.... .|:...||...:||:|...||||.|        :...|..|....:
Human   959 PLRIHVSGSTIAILKRTECQFLYEVRGETYLKGRGNETTYWLTG--------MKDQKFNLPTPPT 1015

  Fly  1152 LKQPQRSQSHNLHKQYSELVVAS 1174
            ::..||.|:     ::|:::..|
Human  1016 VENQQRLQA-----EFSDMIANS 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368	95/427 (22%)
		ANF_receptor	108..473	CDD:279440	89/393 (23%)
		PK_GC-A_B	589..883	CDD:270944	107/308 (35%)
		Pkinase_Tyr	613..877	CDD:285015	101/275 (37%)
		HNOBA	<893..938	CDD:285003	21/44 (48%)
		CYCc	917..1108	CDD:214485	106/191 (55%)
		Guanylate_cyc	944..1130	CDD:278633	109/186 (59%)
GUCY2C	NP_004954.2	PBP1_GC_C_enterotoxin_receptor	35..415	CDD:107364	98/444 (22%)
		PK_GC-C	480..750	CDD:270946	106/305 (35%)
		Pkinase_Tyr	502..745	CDD:285015	101/278 (36%)
		CYCc	788..979	CDD:214485	106/190 (56%)
		Guanylate_cyc	815..1002	CDD:278633	109/186 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D123766at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820