Protein Alignment CG31183 and GUCY1B1

DIOPT Version :10

• Sequence 1: NP_650505.2
• Gene: CG31183 / 41927
• FlyBaseID: FBgn0051183
• Length: 1417
• Species: Drosophila melanogaster
• Sequence 2: XP_011530203.1
• Gene: GUCY1B1 / 2983
• HGNCID: 4687
• Length: 662
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 170/631 - (26%)
• Similarity: 247/631 - (39%)
• Gaps: 209/631 - (33%)

  Fly   632 VQGLLTRSLMLELKRMKDLQHDHLVKFYGA-------CLD--QRRSFLLTEYCPKGSLQDILENE 687
            |.|...|..:..|    |..||||...|..       |.|  :.:..:|..|..:..||||:
Human    89 VLGSNVREFLQNL----DALHDHLATIYPGMRAPSFRCTDAEKGKGLILHYYSEREGLQDIV--- 146

  Fly   688 QFQLDWMFRLSLMHDIVRGMQFLHSSDIRSHGNLKSSNCVVDSRFVLKITDFGLHTLRRTRFDLE 752
                     :.::..:.   |.:|.::|             |.:.:.:..:...|    |:|.:|
Human   147 ---------IGIIKTVA---QQIHGTEI-------------DMKVIQQRNEECDH----TQFLIE 182

  Fly   753 SDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDV--YAFGIIVHEITTRQGPFYL----- 810
            ..  ......::.       :|.|.|.|    |||:..:  |.|        .:..||::
Human   183 EK--ESKEEDFYE-------DLDRFEEN----GTQESRISPYTF--------CKAFPFHIIFDRD 226

  Fly   811 ------GRCAYEKSPQ---------EIIELVKGYNPHRMQKPFRPELEPNGDTKADINGI----- 855
                  |...|...||         .:..||:   || :...|...|       :.||.:
Human   227 LVVTQCGNAIYRVLPQLQPGNCSLLSVFSLVR---PH-IDISFHGIL-------SHINTVFVLRS 280

  Fly   856 ------IRRCWAEDPAERPDFNTLK---SMIRRFNKDN-------ETGNIVDNLLKRMELYANNL 904
                  :.:...||.....:.:.|:   .||.....|:       ...|:.|  |.|..||.:::
Human   281 KEGLLDVEKLECEDELTGTEISCLRLKGQMIYLPEADSILFLCSPSVMNLDD--LTRRGLYLSDI 343

  Fly   905 ------EELV---EERTQDY--------------------HEEKKK------------------- 921
                  .:||   |:..::|                    .:||||
Human   344 PLHDATRDLVLLGEQFREEYKLTQELEILTDRLQLTLRALEDEKKKTDTGCPARIQAFKVQTTLM 408

  Fly   922 -CEK-----------------------LLYQLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGF 962
             |||                       |||.:||.|||.:|...:||.|:.:|.|||.||.||||
Human   409 LCEKDSRSTKGFPSISYSGFLLIPLNRLLYSVLPPSVANELRHKRPVPAKRYDNVTILFSGIVGF 473

  Fly   963 TAISAEST----PMQVVQFLNDLYTCFDSIVE---NFDVYKVETIGDAYMVVSGLPIRNGNQHAR 1020
            .|..::..    .|::|..||||||.||::.:   |..||||||:||.||.||||| .....|||
Human   474 NAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYMTVSGLP-EPCIHHAR 537

  Fly  1021 EIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGACVAGVVGLKMPRYCLFGDTVNTASRMESN 1085
            .|..|||.::|.....::   ..:.:::.||:|||..|.||:|.:||||||||:|||..||.|:.
Human   538 SICHLALDMMEIAGQVQV---DGESVQITIGIHTGEVVTGVIGQRMPRYCLFGNTVNLTSRTETT 599

  Fly  1086 GEALKIHISETTKEAL----DEFGTFVTTRRGFVPMKGKGEMLTYW 1127
            ||..||::||.|...|    :....|....||.|.||||.|.:..|
Human   600 GEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQVW 645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_650505.2	PBP1_NPR-like	87..493	CDD:380596
		PK_GC-A_B	589..883	CDD:270944	54/295 (18%)
		HNOBA	<890..938	CDD:462234	24/119 (20%)
		CYCc	917..1108	CDD:214485	95/244 (39%)
GUCY1B1	XP_011530203.1	HNOB	2..166	CDD:462233	22/108 (20%)
		HNOBA	207..449	CDD:462234	47/262 (18%)
		Guanylate_cyc	455..648	CDD:425528	88/195 (45%)