DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG31183 and GUCY1A1

DIOPT Version :9

Sequence 1:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster
Sequence 2:	NP_000847.2	Gene:	GUCY1A1 / 2982	HGNCID:	4685	Length:	690	Species:	Homo sapiens

Alignment Length:	640	Identity:	187/640 - (29%)
Similarity:	274/640 - (42%)	Gaps:	148/640 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   549 YRHYIAEA-------EINSMSWKVSLEDVMFRDAAERGLRGSFHSLVKQSSQLTLMSEDMVSING 606
            |.|.:||:       |...::  |:|:    |..|:..::.|..||.::..:.|: :|..|:..
Human    70 YLHTLAESICKLIFPEFERLN--VALQ----RTLAKHKIKESRKSLEREDFEKTI-AEQAVAAG- 126

  Fly   607 DRQIFIPVGMFRKS------KVAIKPVEVDNVQGLLTRSLMLELKRMKDL--QHDH--------- 654
                 :||.:.::|      |:..:  |.:|:.|::..:|...|.....|  |..|
Human   127 -----VPVEVIKESLGEEVFKICYE--EDENILGVVGGTLKDFLNSFSTLLKQSSHCQEAGKRGR 184

  Fly   655 LVKFYGACLDQRRSFLLTEY-CPKGSLQDIL------------ENEQFQLDWMFRLSLM------ 700
            |......|||:...||...| .||.:...||            |.|       ..:|||
Human   185 LEDASILCLDKEDDFLHVYYFFPKRTTSLILPGIIKAAAHVLYETE-------VEVSLMPPCFHN 242

  Fly   701 --HDIVRGMQFLHSSDIR------SHGNLKSSNCVVDSRFV------------LKITDFGLHTLR 745
              .:.|.....|:|..::      |....:||..:..|.|.            :.|..|| :.:|
Human   243 DCSEFVNQPYLLYSVHMKSTKPSLSPSKPQSSLVIPTSLFCKTFPFHFMFDKDMTILQFG-NGIR 306

  Fly   746 R--TRFDLESDGGNCNSHAYWSKLLWTAPELLRVEHNRPPEGTQKGDVYAFGIIVHEITTRQGPF 808
            |  .|.|.:   |..|...|:        |:|..:.|:...|               |.|.....
Human   307 RLMNRRDFQ---GKPNFEEYF--------EILTPKINQTFSG---------------IMTMLNMQ 345

  Fly   809 YLGRC-----AYEKSPQ------EIIELVKGYNPHRMQKPFRPELEPNGDTKADINGIIRRCWAE 862
            ::.|.     :.:||.:      ::|.:|:......:..|....||       |..|  |..:..
Human   346 FVVRVRRWDNSVKKSSRVMDLKGQMIYIVESSAILFLGSPCVDRLE-------DFTG--RGLYLS 401

  Fly   863 DPAERPDFNTLKSMIRRFNKDNETGNIVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLY 927
            |   .|..|.|:.::    ...|.....|.|.||:    ..|:..:|:..|...|||||...||.
Human   402 D---IPIHNALRDVV----LIGEQARAQDGLKKRL----GKLKATLEQAHQALEEEKKKTVDLLC 455

  Fly   928 QLLPQSVAAQLISGQPVVAETFDQVTIYFSDIVGFTAISAESTPMQVVQFLNDLYTCFDSIVENF 992
            .:.|..||.||..||.|.|:.|..||:.||||||||||.::.:|:||:..||.|||.||......
Human   456 SIFPCEVAQQLWQGQVVQAKKFSNVTMLFSDIVGFTAICSQCSPLQVITMLNALYTRFDQQCGEL 520

  Fly   993 DVYKVETIGDAYMVVSGLPIRNGNQHAREIARLALALLEAVHNFRIHHRPEDRLKLRIGLHTGAC 1057
            ||||||||||||.|..||. :..:.||.:||.:||.::|........|  .:.:|:|||||:|:.
Human   521 DVYKVETIGDAYCVAGGLH-KESDTHAVQIALMALKMMELSDEVMSPH--GEPIKMRIGLHSGSV 582

  Fly  1058 VAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHISETTKEALDEFGTFVTTRR 1112
            .|||||:|||||||||:.|..|::.||.....||::|.||...|.:...||.|.|
Human   583 FAGVVGVKMPRYCLFGNNVTLANKFESCSVPRKINVSPTTYRLLKDCPGFVFTPR 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	70/362 (19%)
		Pkinase_Tyr	613..877	CDD:285015	67/332 (20%)
		HNOBA	<893..938	CDD:285003	16/44 (36%)
		CYCc	917..1108	CDD:214485	93/190 (49%)
		Guanylate_cyc	944..1130	CDD:278633	83/169 (49%)
GUCY1A1	NP_000847.2	HNOBA	277..466	CDD:400168	51/235 (22%)
GUCY1A1	NP_000847.2	Guanylate_cyc	472..643	CDD:306677	83/169 (49%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810